The Nicolas Andry Award-1995. Fracture healing. Radiation induced alterations

This study investigated the effects of radiation on fractures in a rat femur model. Two different radiation dosage fractionation schemes (1100 rads given in one dose and 2500 rads given in 10 divided doses over 12 days) and three different times of initiation of radiation (1 day before fracture, 3 or 10 days after fracture) were studied. Fractures exposed to these levels of radiation all appeared to heal during the course of this experiment, although with varying degrees of delay, with the exception of those exposed to a single dose of 1100 rads 3 days after fracture. These animals remained at a more immature level of repair histologically compared with the control group, throughout the entire time evaluated. The strength of the final repair remained less than the control for all the groups receiving treatment. These results may offer some explanation for the clinical observations of an increased incidence of delayed union and nonunion of fractures, an increased incidence of fracture and refracture in irradiated bone, and an increased incidence of fracture and nonunion in constructs using radiation in conjunction with allogeneic bone. Furthermore, the observed effects were generally no different in the animals treated with the two clinically relevant dose fractionation schemes chosen for this study.     

LP-BM5 virus causes changes in lactic dehydrogenase and oxygen radical production in splenocytes of C57BL/6J mice

The LP-BM5 murine leukemia virus causes acquired immunodeficiency syndrome in C57BL/6J mice (MAIDS), similar to that of AIDS in humans. The objective of this study was to determine the effect of LP-BM5 viral infection on cellular activation and membrane integrity of splenocytes. Oxidative burst in splenocytes in response to exposure to PMA (20 microg/ml) was significantly higher (p<.02) in infected than in control mice at two weeks post-infection using luminol-enhanced chemiluminescence. By 13 weeks post-infection superoxide anion production in infected mice was significantly lower when compared to controls coinciding with decreased proliferative response to mitogens. The extent of cell membrane damage as indicated by lactic dehydrogenase (LDH) activity in serum was significantly higher in infected than in control mice (p<.001). The results from this study suggests that LP-BM5 virus causes an initial stimulation of cellular activity followed by a decreased cell activation characterized by decreased proliferation of splenocytes and decreased oxygen radical production. Decreased cell membrane integrity indicated by increased LDH activity may partly be responsible for these changes.     

用迁移率和载流子浓度研究碲镉汞中的深能级

获得了一种研究碲镉汞深能级的方法。通过分析迁移率 载子浓度与温度的关系，可以得到关于深能级的重要依据。     

多晶 Na-β″-Al_2O_3的 Ag~+交换及性能研究

研究了多晶 Na-β″-Al_2O_3的 Ag 离子交换动力学,采用一维双面扩散模型处理,求得离子交换过程中 Na~+、Ag~+的互扩散系数.样品的形貌和结构采用 EPMA、SEM、XRD 等分析技术进行观察和分析.测试了 Na-β″-Al_2O_3和 Ag-β″-Al_2O_3及部分 Ag~+交换的 Na/Ag-β″-Al_2O_3样品的电导率,并进行了理论分析.     

跟踪系统中跟踪器延迟的自适应预测补偿方法

跟踪系统中跟踪器的延迟会对系统的稳定性和跟踪精度产生不利影响。为此以典型Ⅱ型系统为例，理论上定理地分析了跟踪器延迟对跟踪系统的影响，并提出了将采用LMS算法和横向滤波器结构的自适应滤波器用于延迟预测补偿的方法。仿真结果验证了方法的有效性。     

无明胶重铬酸盐全息记录软片的正性光抗蚀特性

对无明胶重铬酸盐全息记录软片（ＮＧＤ）的光正性抗蚀特性进行了分析研究，通过对溶解度的分析及红外光谱的测定，首次提出ＮＧＤ是一种新型的紫外正性光抗蚀材科，给出了实验及分析结果。     

ERCM与数据库设计

本文介绍了一种实用的数据库设计方法，它以实体分析法为理论基础，通过对我们日常使用的表进行聚集和归类，完成数据库的逻辑设计，所设计的数据库满足ＢＮＯＦ范式。同时该方法可操作性较强，本文还介绍了自行设计的ＥＲＣＭ数据库辅助设计工具。     

A common precursor to neurotensin and LANT6 and its differential processing in chicken tissues

Antisera towards neurotensin (NT) and the structurally related peptide, LANT6, were used to characterize immunoreactive peptides and proteins in extracts of chicken tissues. A 17 kDa protein was identified by Western blotting as a potential precursor to NT and LANT6. However, the posttranslational processing of this common precursor appeared to be tissue specific, giving rise to disproportionate amounts of NT and LANT6, along with varying expression of a large molecular LANT6 (M(r), 15 kDa). The intestinal cells containing immunoreactive NT, LANT6, and large molecular LANT6 behaved similarly during fractionation by size and density. These activities also banded together in particles resembling vesicles during centrifugation of isotonic homogenates of tissue. These results suggest that chicken NT and LANT6 are biosynthesized as parts of the same precursor, the processing of which can give rise to a variety of products stored within secretory vesicles.