Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children

Potentially traumatic experiences have been associated with chronic diseases. Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed as an explanation for this association. We examined the association of experiences of trauma with epigenome-wide DNAm among African American mothers (n = 236) and their children aged 3–5 years (n = 232; N = 500), using the Life Events Checklist-5 (LEC) and Traumatic Events Screening Inventory—Parent Report Revised (TESI-PRR). We identified no DNAm sites significantly associated with potentially traumatic experience scores in mothers. One CpG site on the ENOX1 gene was methylome-wide-significant in children (FDR-corrected q-value = 0.05) from the TESI-PRR. This protein-coding gene is associated with mental illness, including unipolar depression, bipolar, and schizophrenia. Future research should further examine the associations between childhood trauma, DNAm, and health outcomes among this understudied and high-risk group. Findings from such longitudinal research may inform clinical and translational approaches to prevent adverse health outcomes associated with epigenetic changes.     

基于迭代线性约束最小方差的稳健自适应脉冲压缩方法

针对常规自适应脉冲压缩方法在目标散射点与采样中心失配时旁瓣抑制性能下降的问题,该文提出一种基于迭代线性约束最小方差(RLCMV)的自适应脉冲压缩方法。该方法首先将自适应波束形成器算法引入到自适应脉冲压缩滤波器设计中。其次对目标及干扰单元进行线性约束,并用对角加载技术避免矩阵出现病态。最后构造了迭代运算方法,依次抑制不同大小目标的距离旁瓣。仿真结果表明,该算法可以有效抑制散射点随机分布目标的距离旁瓣,对散射点与采样中心失配情况具有较好的稳健性,在多目标及距离扩展目标场景中达到较好的旁瓣抑制性能,并在一定程度上提高了多普勒容性。     

连续波穿透雷达柱面成像的干涉条纹抑制研究

在进行单频连续波表层穿透雷达的柱面2维无损检测成像扫描时,发现明暗相间的条纹现象,这是雷达成像扫描的一种主要干扰,会严重降低目标的成像效果。该文简单分析了曲面干涉条纹的产生机理,并且基于柱面与目标的谱域分布特性差异,提出谱域干涉条纹滤波方法。针对小目标具有较规律的谱域角度分布特性,沿角度进行谱域插值的补偿,以消除谱域滤波丢失目标谱信息的影响。此外,结合波前成像算法,给出了实现简单、处理高效的谱域滤波成像处理流程。通过仿真分析和实测数据实验,结果表明该文方法能够有效去除柱面的干涉条纹,形成清晰的目标图像。与传统的减平均方法的对比证实该文方法更有效。     

大涝坝凝析气藏循环注气注采参数优化研究

大涝坝凝析气藏在衰竭式开发过程中,受反凝析和水侵的双重影响,产能快速下降,为提高采收率,开展了循环注气开发.注采参数是影响循环注气采收率及经济效益的主要指标.针对大涝坝这类开发中后期进行循环注气的水驱凝析气藏,该文通过数值模拟方法,开展注采比、注采方式等注采参数优选,优化循环注气方案,保证了循环注气开发的效果.     

塔河油田碳酸盐岩油藏定量化注水提高水驱效率现场应用与研究

塔河油田碳酸盐岩油藏具有埋藏深、非均质性强的特点,主要储集空间以溶孔、溶洞和裂缝为主,裂缝为主要渗流通道。随着油田能量的递减,注水做为补充能量最经济有效的方式得到大力推广。根据物质平衡原理,依托酸压曲线、注水指示曲线、能量指示曲线,对注水进行定量化计算,精细注水,明确注采关系,优化注采参数,推动油田提高水驱效率和采收率。     

塔河油田X区块奥陶系沥青质油井防堵技术研究

塔河油田X片区奥陶系区块油井陆续出现沥青质堵物堵塞油管、生产管线,造成油井停产,对生产造成了严重影响。针对此类问题,对塔河油田X片区奥陶系原油中沥青质的沉积问题进行了综合研究,得到了有效的油井沥青质防堵生产技术。通过对塔河油田X区块奥陶系原油组分、沥青质沉积堵塞物的分析,发现沥青质沉积主要是由于原油组分中饱和烃含量高,胶质沥青质之比过低,由此发展了沥青分散剂解堵、排出段塞堵物、井口流程优化等治堵工艺。通过试验发现,这些工艺较好地解决了沥青质沉积堵塞油井及管线的问题。     

边际核函数在生物序列分类中的应用

在核方法的基础上,介绍了一种自潜变量生成模型构造核函数的新方法;并专门探讨了结合生物序列的自身特点,按照该方法提取了几个边际核函数;随后将它们应用于具体的gyrB(旋转酶B亚单位)氨基酸序列分类实验中,实验结果表明边际核具有良好的识别效果及极佳的推广能力,也肯定了此种核构造方法的先进性.     

A Novel Robust Zero-Watermarking Algorithm for Audio Based on Sparse Representation

Behind the prevalence of multimedia tech-nology, digital copyright disputes are becoming in-creasingly serious. The digital watermarking pre-vention technique a...     

Two-Timescale Online Learning of Joint User Association and Resource Scheduling in Dynamic Mobile Edge Computing

For the mobile edge computing network consisting of multiple base stations and resource-constrained user devices, network cost in terms of energy and delay will...     

Effect of electrode change on solidification of slag and metal pool profile in electroslag remelting process

A two-dimensional axisymmetric model is established to study the effect of electrode change on the solidification of slag and metal pool profile during electros...