Noninvasive assessment of the direct action of oral nifedipine and nicardipine on left ventricular contractile state in patients with systemic hypertension: importance of reflex sympathetic responses

BACKGROUND: Alveolar macrophages from patients with sarcoidosis were analyzed for their ability to secrete tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta), and interleukin-6 (IL-6). RESULTS: Constitutive release of all three monokines in these patients was concomitantly increased in the active state of disease in comparison with inactive sarcoidosis or healthy control subjects. Alveolar macrophages from patients with inactive sarcoidosis compared with cells from healthy subjects showed increased spontaneous secretion of TNF-alpha and IL-6 only, whereas the constitutive release of IL-1-beta was similar as in healthy volunteers. In vitro stimulation of alveolar macrophages from healthy control subjects with lipopolysaccharide or pokeweed mitogen led to a time- and dose-dependent enhanced secretion of TNF-alpha, IL-1-beta, and IL-6. In a similar manner, with corresponding cells from patients with sarcoidosis the secretion of all three cytokines could be further increased by stimulation with lipopolysaccharide or pokeweed mitogen. CONCLUSIONS: The data presented indicate that an increased release of TNF-alpha, IL-1-beta, and IL-6 correlates to disease activity and may play a critical part in the pathogenesis of sarcoidosis.     

The performance of foliage mass and crown radius models in forming the input of a forest reflectance model: A test on forest growth sample plots and Landsat 7 ETM+ images

Several published foliage mass and crown radius regression models were tested on the preparation of the input for the reflectance model of Kuusk and Nilson [Kuusk, A. and Nilson, T. (2000), A directional multispectral forest reflectance model. Remote Sensing of Environment, 72(2):244–252.] for 246 forest growth sample plots in Estonia. In each test, foliage mass and crown radius for trees in the sample plots were predicted with a particular pair of allometric regression models. The forest reflectance model was then run using the estimated foliage mass and crown radius values. Reflectance factors were simulated and compared with the reflectance values obtained from three atmospherically corrected Landsat 7 Enhanced Thematic Mapper (ETM+) scenes. The statistics of linear regression between the simulated and measured reflectance factors were used to assess the performance of foliage and crown radius models. The hypothesis was that the best allometric regression models should provide the best fit in reflectance. The strongest correlation between the simulated and measured reflectance factors was found in the short-wave infrared band (ETM + 5) for all the images. The highest R² = 0.71 was observed in Picea abies dominated stands. No excellent combination of foliage mass and crown radius functions was found, but the ranking based on determination coefficients showed that some linear crown radius models are not applicable to our data. Processing of raster images, reflectance measurement for small sample plots, usage of tree-species-specific fixed parameters (specific leaf area, etc.), and the ignored influence of phenology introduced additional variation into the relationships between simulated and measured reflectance factors. Further studies are needed, but these preliminary results demonstrate that the proposed method could serve as an effective way of testing the performance of foliage mass and canopy cover regressions.     

Field Measurements with a 5.25 GHz Broadband MIMO-OFDM Communication System

Theoretical capacity calculations and corresponding simulations show significant capacity/throughput gains from MIMO systems. Whether these gains are achievable in a real system, deployed in a practical environment, depends on a variety of factors, such as the choice of the communication algorithms, analog impairments and the "quality" of the wireless channel to sustain MEMO communications. In this paper, a 5.25 GHz broadband MIMO-OFDM testbed is described along with field measurements conducted with it. The MIMO-OFDM communication algorithms and also the impact of analog impairments on the performance of the system are described. Detailed system calibration results are described which serve as a baseline for results of field measurements. The results of wireless measurements are compared with the theoretical capacity, computed with the channel estimates obtained during the demodulation process. The average achievable capacity in the indoor wireless environment is shown to be 9.97 bps/Hz (bits per sec per Hz) while the capacity loss due to analog impairments and the choice of algorithms is about 2.33 bps/Hz. Also, field measurements conducted with the system in various environments are presented comparing the average throughput/capacity achieved in each of these environments.     

LED大屏幕动态显示的实现

本文介绍了一种基于并行通讯的ＬＥＤ大屏幕动态显示的实现方案，包括发送和接收的软，硬件设计以及多机通讯技术。     

Effects of the Na+/H+-exchange inhibitor Hoe 642 on intracellular pH, calcium and sodium in isolated rat ventricular myocytes

The inhibitors of the Na+/H+-exchange (NHE1) system Hoe 694 and Hoe 642 possess cardioprotective effects in ischaemia/reperfusion. It is assumed that these effects are due to the prevention of intracellular sodium (Nai) and calcium (Cai) overload. The purpose of the present study was to investigate the effects of Hoe 642 on intracellular pH, Na+ and Ca2+ (pHi, Nai and Cai) in isolated rat ventricular myocytes under anoxic conditions or in cells in which oxidative phosphorylation had been inhibited by 1.5 mmol/l cyanide. In cells which were dually loaded with the fluorescent dyes 2, 7-biscarboxyethyl-5,6-carboxyfluorescein (BCECF) and Fura-2, anoxia caused acidification of the cells (from pHi 7.2 to pHi 6.8) and an increase in Cai from about 50 nmol/l to about 1 micromol/l. The decrease in pHi began before the cells underwent hypoxic (rigor) contracture, whereas Cai only began to rise after rigor shortening had taken place. After reoxygenation, pHi returned to its control value and Cai oscillated and then declined to resting levels. It was during this phase that the cells rounded up (hypercontracture). When 10 micromol/l Hoe 642 was present from the beginning of the experiment, pHi and Cai were not significantly different from control experiments. At reoxygenation, pHi did not recover, but Cai oscillated and returned to its resting level. To monitor Nai, the cells were loaded with the dye SBFI. After adding 1.5 mmol/l cyanide or 100 micromol/l ouabain, Nai increased from the initial 8 mmol/l to approximately 16 mmol/l. Hoe 642 or Hoe 694 (10 micromol/l) did not prevent the increase in Nai. In contrast, the blocker of the persistent Na+ current R56865 (10 micromol/l) attenuated the CN--induced rise in Nai. The substance ethylisopropylamiloride was not used because it augmented considerably the intensity of the 380 nm wavelength of the cell's autofluorescence. In conclusion, the specific NHE1 inhibitor Hoe 642 did not attenuate anoxia-induced Cai overload, nor CN--induced Nai and Cai overload. Hoe 642 prevented the recovery of pHi from anoxic acidification. This low pHi maintained after reoxygenation may be cardioprotective. Other possible mechanisms of NHE1 inhibitors, such as prevention of Ca2+ overload in mitochondria, cannot be ruled out. The increase in Nai during anoxia is possibly due to an influx of Na+ via persistent Na+ channels.     

Thermolysis of poly(diaryl diazosulfide)s

Poly(diaryl diazosulfide)s and model diaryl diazosulfides of the general structure aryl-N?N? S-aryl' are tested for their thermostability. Thermolysis in solution is followed by means of UV spectroscopy. At the beginning of the decay most model diazosulfides follow first-order kinetics, but show an acceleration of the decay rate in the further course of the thermolysis. In contrast to the models the decomposition of the corresponding polymers cannot be described by first-order kinetics, except one example ( P 1 ). Thermogravimetry studies show weight losses of 8–12% in the range between 80 and 150°C depending on the structure of the models and polymeric diazosulfides. These values correspond with the content of azo function in these compounds, therefore it is assumed that nitrogen is split off under these reaction conditions.     

沥青基高比表面积活性碳的物理及化学结构

本文用ＡＳＡＰ２０００吸附仪测定了吸附性能优异的沥青基高比表面积新型活性碳（ＰＨＡＣ）的ＢＥＴ比表面积、用ＢＪＨ和ＤＲＳ法分析了其孔隙结构参数，用ＸＰＳ测定了ＰＨＡＣ的表面元素组成及含氧官能团，对ＰＨＡＣ的表面形态结构进行了ＳＥＭ和ＴＥＭ观察。研究表明：ＰＨＡＣ具有高度发达且均匀的微孔结构，其表面含有一定量的Ｃ－Ｏ－Ｃ、Ｃ－ＯＨ、Ｃ＝Ｏ、Ｏ＝Ｃ－Ｏ等多种类型的含氧官能团。