Electron spin resonance of DNA irradiated with a heavy-ion beam ([16]O[8+]): evidence for damage to the deoxyribose phosphate backbone

A major problem in the intensive care unit nowadays is the development of multiple organ dysfunction syndrome (MODS), a cumulative sequence of progressive deterioration of organ functions. While the pathogenic pathways of MODS remain to be elucidated, it is assumed that cells of the host defence system, especially the macrophages, are altered in their function. During the development of MODS it is assumed that macrophages are overactivated and that an exaggerated inflammatory response may contribute to its pathogenesis. In order to gain insight into the alterations of the functional status of the macrophage during the development of MODS, a series of macrophage functions was measured in the subsequent phases of zymosan induced generalized inflammation in mice. Male C57BL/6 mice received a single dose of zymosan intraperitoneally and groups of animals were killed after 2, 5, 8, and 12 days. Peritoneal macrophages were collected for in vitro assessment of the ADCC, the production of superoxide (O2-) and nitric oxide (NO), and complement mediated phagocytosis and intracellular killing of Staphylococcus aureus. A single intraperitoneal injection with zymosan resulted in a three-phase illness. During the third phase the animals developed MODS-like symptoms. Peritoneal cells from control animals produced very low to non-detectable amounts of O2- and NO, and the cytotoxic activity was also low. During the development of MODS, from day 7 onwards, the ability to produce O2- and NO2- became strongly elevated, as did the cytotoxic activity. These findings are in parallel with the development of MODS whereas the phagocytic and killing capacity remained essentially unaltered. The changes found could be detrimental for the organism, thus possibly contributing to the onset and development of MODS.     

InGaAs（P）分别限制应变单量子阱激光器的优化设计

针对较常用的ＩｎＧａＡｓ（Ｐ）分别限制应变单量子阱激光器，给出了为得到最大净增益的优化设计参数。对于激射波长为１．５５μｍ的无应变激光器，最佳的光限制层波长为１．２４μｍ，厚度为１００ｎｍ。当阱材料引入压缩应变后．由于价带的有效状态密度减小，量子阱激光器的微分增益变大，阱深的增大对增大线性增益的效果更加明显．所以最佳光限制层的波长将变短，为１．２０μｍ     

高校合并后图书馆的发展走向

高校合并后，给图书馆带来了一定的发展契机，高校图书馆如何在挑战与机遇并存的新形势下，摆正自己的位置，加强科学管理，充分利用有利因素加快图书馆的数字化进程，使图书馆的服务更具有人性化和科学化，是今后图书馆发展所面临的一个新的课题。     

Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 under the dose of 100 mg/kg increased the signal intensity of NOFe2+(DETC)2 complex, while EGb 761 at 200 mg/kg showed an effect of decreasing the signal intensity of NOFe2+(DETC)2 complex. EGb 761 inhibited the formation of TBARS, the release of CK, and mitigated the incidence of ventricular arrhythmias in a dose dependent way. Both l-arginine and SOD increased the signal intensity of NOFe2+(DETC)2 complex and inhibited the formation of TBARS, the leakage of CK and the incidence of ventricular arrhythmia. NNA not only had no protective effects on myocardial injury, but also increased the incidence of reperfusion-induced arrhythmia. In conclusion, EGb 761 has cardiovascular protective effects by means of adjusting the level of NO and inhibiting oxygen free radicals induced lipid peroxidation in myocardial ischemia-reperfusion injury in vivo.     

As,Sb,Sn对30CrMnSiA钢力学性能的影响

在３０ＣｒＭｎＳｉＡ钢中加入不同量的Ａｓ，Ｓｂ，Ｓｎ元素，研究了这些元素单独存在及复合存在时对钢的强度，塑性，冲击韧度及韧脆转变温度的影响规律，并用扫描电镜及俄歇能谱分析了Ａｓ，Ｓｂ，Ｓｎ导致晶界脆化的机理。     

AKIMA方法在EXAFS谱解析中的应用

解析扩展Ｘ射线吸收精细结构谱（ＴｈｅＥｘｔｅｎｄｅｄＸ－ｒａｙＡｂｓｏｒｐｔｉｏｎＦｉｎｅＳｔｒｕｃｔｕｒｅＥＸＡＦＳ）的一种方法是曲线拟合，在曲线拟合中，能量阈值Ｅ０的确定有着很重要的意义，同时也有相当的难度，本文应用ＡＫＩＭＡ平滑数据点方法达到了对Ｅ０在数学意义上的精确求解，数据分析结果表明，这种方处理结果是令人满意的。     

A sequencing problem for a mixed-model assembly line in a JIT production system

In an assembly line of a just-in-time (JIT) production system, workers have the power and the responsibility to stop the line when they fail to complete their operations within their work zones. This paper deals with a sequencing problem for the mixed-model assembly conveyor line in the JIT production system. In some environment, the most important criterion is the line stoppage rather than the variation of production rates. The problem is to find an optimal sequence of units that minimizes the total line stoppage time. Lower and upper bounds of the total line stoppage time are derived and the branch-and-bound method is applied to the problem. A numerical example is given.     

气体动压轴承动态参数测定原理

将气体动压轴压简化为转化气膜系统后，针对其动力特点，给出气膜在微幅振动下动压轴承的实用数学模型和测定动态参数的方法，并进行了测量误差的修正。