miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.     

高速轧机润滑油品含水率实时检测系统的设计与应用

本文简要介绍了高速轧机润滑油品含水率实时检测系统的设计内容与应用情况,本系统使用效果明显,在国内本专业领域处于领先地位。     

BOPP薄膜市场现状及发展趋势

介绍了我国双向拉伸聚丙烯薄膜的市场现状,并对其发展趋势进行了展望。     

WT615增压CNG电喷发动机燃烧特性数值分析

以WT615 CNG发动机为模拟研究对象,采用KIVA-3V软件建立了多维软件计算模型,并验证了模型的准确性。在此基础上研究了主要结构参数——燃烧室形状对燃烧特性和整机性能的影响。研究表明,直口形燃烧室的动力性、经济性能最好,更加适用于该天然气发动机,但排放性能有待提高;缩口形燃烧室的整机性能次之,碗形燃烧室的动力性和经济性则较差,后燃现象严重,不适用于天然气发动机。     

大型水电机组的无级调速技术

介绍了大型水电机组无级调速的两项先进技术,一是利用静止歇尔皮斯系统,另一是大型无换向器电机技术。     

高压直流输电线路对通信明线影响的仿真研究

如何评价高压直流输电线路直流谐波对附近通信明线的影响,对确保通信线路正常、安全运行,以及直流输电工程的建设有着十分重要的意义.根据强电线路对弱电线路的耦合影响理论,高压直流输电线路对通信明线的影响分为危险影响和干扰影响两部分,本文介绍了高压直流输电线路对通信明线影响的原理及计算分类,以及目前国内主要的高压直流输电线路对通信明线影响的限值,并对不同参数变化下的静电感应电压和杂音电动势变化情况进行了仿真,得出了结论,为直流工程设计提供了一些参考.最后给出了具体模型进行了计算.     

热成像系统NETD自动测量方法研究

论述了红外热成像系统NETD测量的理论基础,设计了一种该参数的自动测量方法,并搭建了试验平台.该平台先设置不同温差的靶标,再通过采集卡将热像仪的模拟视频采集到计算机,然后通过WINDOWS程序对数据进行处理,最后计算出热像仪的NETD.试验结果表明,该参数的自动测量可以工程化实现.     

Three-dimensional graphene and its composite for gas sensors

As a two-dimensional (2D) material,graphene shows excellent advantages in the field of gas sensors due to its inherent large specific surface area and unique el...     

含大规模新能源的电力系统STATCOM选址及容量优化

为了改善含大规模新能源电力系统电压稳定性,针对大电网系统提出了一种基于分区优化的静止同步补偿器（static synchronous compensator, STATCOM）动态无功多目标选址定容方法。提出了一种基于电气距离和暂态电压特性的分区方法,能够有效地考虑电力系统拓扑结构、线路参数以及励磁系统参数和稳定器参数等对电力系统分区的影响;采用电压控制指标辨识STATCOM最优安装节点;构建了包含投资成本、静态电压稳定指标和暂态电压严重性指标的多目标动态无功规划模型;采用基于自适应协方差矩阵和混沌搜索的多目标群搜索优化算法和熵权理想度排序法对多目标无功规划模型进行求解和决策推理。对所提方法在某省级规划电网中进行了测试,仿真结果表明,优化后的STATCOM配置方案能够有效改善电力系统静态和暂态电压稳定性。