A distributed adverse drug reaction detection system using intelligent agents with a fuzzy recognition‐primed decision model

Discovering unknown adverse drug reactions (ADRs) in postmarketing surveillance as early as possible is highly desirable. Nevertheless, current postmarketing surveillance methods largely rely on spontaneous reports that suffer from serious underreporting, latency, and inconsistent reporting. Thus these methods are not ideal for rapidly identifying rare ADRs. The multiagent systems paradigm is an emerging and effective approach to tackling distributed problems, especially when data sources and knowledge are geographically located in different places and coordination and collaboration are necessary for decision making. In this article, we propose an active, multiagent framework for early detection of ADRs by utilizing electronic patient data distributed across many different sources and locations. In this framework, intelligent agents assist a team of experts based on the well‐known human decision‐making model called Recognition‐Primed Decision (RPD). We generalize the RPD model to a fuzzy RPD model and utilize fuzzy logic technology to not only represent, interpret, and compute imprecise and subjective cues that are commonly encountered in the ADR problem but also to retrieve prior experiences by evaluating the extent of matching between the current situation and a past experience. We describe our preliminary multiagent system design and illustrate its potential benefits for assisting expert teams in early detection of previously unknown ADRs. © 2007 Wiley Periodicals, Inc. Int J Int Syst 22: 827–845, 2007.     

钛制设备在焦化行业中的应用

介绍焦化行业钛设备的应用,剖析了分块式钛泡罩塔盘的结构特点,并对其经济性作了分析。     

我国矿业城市实现可持续发展的途径分析

详细分析我国矿业城市可持续发展所面临的社会、经济、资源和生态环境等问题，提出了我国矿业城市应树立可持续发展目标及其内涵，系统分析矿业城市可持续发展的结构和模式，结合我国矿业城市发展存在的主要问题，以矿业城市可持续发展理念为指导，提出我国矿业城市实现可持续发展的途径及其建议。     

以能力培养为主线组织课堂教学

从能力培养的角度较全面、系统地阐述了教师组织课堂教学的基本方法和手段。并针对职业教育的培养要求及学生的心理特点,在有效整合学校各种教学资源、努力实现学生知识结构与能力培养和谐统一方面进行了一些有益探索和实践。     

本钢炼焦煤最佳配比分析

结合本钢的生产实际，对炼焦煤的最佳配比作了比较具体的分析，同时对资源，质量、成本也作了比较详细的调查，并提出了本钢焦化厂最佳配煤比方案，由此可看出，最大限度地降低采购成本，继续开发合理的配煤比例，具有广阔的前景。     

用VISUAL FOXPRO设计专业产品数据库

根据专业产品数据库的特点和安全性要求提出了基本设计思想，包括根据用户权限进行检索，建立了Ａ，Ｂ库，形成不同视图以满足不同用户需求。     

Prognostic factors of early sequelae and fatal outcome of Japanese encephalitis

A clinical case control study to identify prognostic factors present at hospital admission associated with early sequelae and fatal outcome of acute Japanese encephalitis (JE) was carried out in Gusi county, Henan Province, central China from June to September 1991. A total of 70 patients with laboratory-confirmed acute JE were studied, of whom 3 cases died and 33 cases had neurological or psychiatric sequelae at the end of three months follow-up. The results showed that acute JE at younger age, with higher body temperature, high white cell count in CSF, and deep coma present at hospital admission were markers for unfavorable outcomes (sequelae or fatal). A history of the vaccination was not correlated with the early sequelae and fatal outcome of the disease. The paper suggests that early diagnosis and treatment and universal JE vaccination for all susceptible populations are keys for decreasing incidence of sequelae and fatal outcome of acute JE.     

片状陶瓷材料高低温电性能参数的自动检测

由进口电性能仪配上自制的高温系统，计算机自动采集数据，配置成一套高低温电性参数测定装置，该装置的特点是，升温快，炉体小巧，炉芯可更换盛液氮装置，屏蔽良好，等温区长，温工及参数测量精确可靠。     

PPS：基于PROSITE数据库检索蛋白质功能位点的计算机程序

用标准Ｃ语言在ＩＢＭ－ＰＣ兼容微机上开发了基于ＰＲＯＳＩＴＥ数据库检索蛋白质序列功能位点的ＰＰＳ程序，ＰＲＯＳＩＴＥ是Ｂａｉｒｏｃｈ建立的蛋白质功能位点或结构模式的资料库，为蛋白质序列分析和结构功能研究提供了新工具。