胰岛素对初发2型糖尿病的疗效及影响

目的:观察胰岛素对初发2型糖尿病的疗效及不良反应,以及对血糖的影响.方法:选择2008年1月至2010年1月在我院住院的T2DM患者为观察对象.120例初发2型糖尿病患者随机分为治疗组和对照组各60例,治疗3个月后,观察治疗的疗效及对血糖控制情况.结果:治疗组的疗效优于对照组,且治疗组血糖控制效果明显优于对照组,差异有统计学意义(P＜0.05).结论:胰岛素对初发2型糖尿病疗效确切,更好地降低T2DM血糖水平,值得基层医院广泛推广和应用.     

Radiation synthesis of PVP/CMC hydrogels as wound dressing

Carboxymethyl cellulose (CMC) and poly(N-vinyl pyrrolidone) (PVP) were blended to synthesize hydrogels by ⁶⁰Co γ-ray irradiation. A series of hydrogels were prepared with three compositions, i.e. PVP:CMC = 5:5, 6:4 and 7:3. The properties of the hydrogels such as gel fraction, gel strength, swelling behavior and moisture retention were investigated. Compared with pure PVP and CMC hydrogels, PVP/CMC blend hydrogels possessed improved gel strength, flexibility and transparency. As the content of PVP in PVP/CMC blend hydrogels increased, the gel fraction increased while the swelling rate decreased. The hydrogels with optimal properties were obtained in a composition of PVP/CMC = 6/4 with sterilization dose (25 kGy) and further characterized by FT-IR and SEM. Properties concerning the application of wound dressing were performed by comparison with a commercial hydrogel wound dressing to find a similar moisture retention capability and improved swelling rate. The improved properties as well as the cheapness of the materials suggest that PVP/CMC blend hydrogel can be good candidate as wound dressing.     

用CR－39固体径迹探测器测定重带电粒子的Bragg峰位

采用ＣＲ－３９固体径迹探测器，根据辐射损伤密度沿粒子的径迹分布规律，测定了经３、４ｃｍ空气降能和φ１ｍｍ孔准直的α粒子（５．１５ＭｅＶ）的Ｂｒａｇｇ峰位。对于通过３ｃｍ空气后能量降至～１２ＭｅＶ的α粒子，在ＣＲ－３９中的Ｂｒａｇｇ峰位大约在７μｍ深度处，理论计算值在６．１４μｍ，实验值与理论值符合得较好。     

新城金矿床围岩蚀变与金矿化的关系

本文就新城金矿围岩蚀变的特征、与金矿化的关系、金与多金属硫化物的关系、依变岩石中金的富集规律进行了探讨,指出了围岩蚀变是重要的成矿地质条件．     

铁（Ⅲ）－1，10－二氮杂菲－甲基橙三元络合物光度法测定铁的研究

提出了铁（Ⅲ）－１,１０－二氮杂菲（Ｐｈｅｎ）－甲基橙（ＭＯ）三元络合物体系光度法测定Ｆｅ（Ⅲ）的新方法。该方法的灵敏度高（ε＝８．１×１０４）,选择性好,准确可靠,用于测定金属和化学试剂中痕量铁,结果满意。     

Effects of Technical Conditions on Structure, Morphology and Crystalline Size of Nanocrystalline Nd-Doped Ceria Powders

Nanocrystalline solid solution CeO2-Nd2O3 powders were prepared by low temperature combustion process.Special attention was paid to the influence of the glycine/metal ratio and calcination temperature on the powders phase structure, morphology and particle size.TG-DSC curves and XRD peaks of different glycine/metal ratio show that smaller particle size can be obtained with a slightly fuel-deficient ratio.XRD results indicate that the as-prepared powders are crystallized in a single fluorite structure.The crystalline size ranges from 9 to 24 nm, which increases with the increase of calcination temperature.The lower SEM images were characterized by the spongy and form-like microstructure of the powders.Organic agent may be gradually eliminated by high temperature calcination process.     

金矿矿源层和含金建造刍议

在矿源层评价中,相对于岩石中的金丰度,金的赋存状态具有更重要的意义,因此在工作中应恢复岩石的原始含金性,并计算区域金丰度值.本文还讨论了含金建造的概念、分布和评价准则等问题.     

p53 codon 72 polymorphism in Taiwanese lung cancer patients: association with lung cancer susceptibility and prognosis

Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues. We have now assessed the effect of this agent in vivo on the nasal epithelium of CF mutant mice and also in the nose and lungs of human subjects with CF. Wild-type mice showed a small hyperpolarization of the nasal potential difference (PD) in response to milrinone (100 microM, 1.6 +/- 0.6 mV, n = 8, P < 0.05). In contrast, CF mice carrying either the most common human mutation of the gene for the CF transmembrane regulator (CFTR), DeltaF508 (protein mislocalized), or the G551D mutation (protein normally localized) failed to demonstrate this response. Milrinone perfused alone had no significant effect on the baseline nasal PD of human subjects without CF (14.7 +/- 4.0 mV preperfusion; 15.3 +/- 4.6 mV postperfusion), but significantly (P < 0.05) augmented the hyperpolarization induced by a subsequently perfused low-chloride solution (with milrinone, 36.8 +/- 3.0 mV, n = 6; without milrinone, 18.1 +/- 2.2 mV, n = 19). In contrast, in human subjects with CF (n = 6), milrinone alone significantly (P < 0. 05) altered the nasal baseline PD (52.2 +/- 3.3 mV preperfusion; 57. 4 +/- 4.2 mV, postperfusion) but not the subsequent responses to the low-chloride solution (with milrinone, 1.1 +/- 2.2 mV, n = 4; without milrinone, 0.6 +/- 0.5 mV, n = 28) or to isoproterenol (100 microM). In a separate study in subjects (n = 6) with the DeltaF508 mutation, nasal coadministration of milrinone with isoproterenol produced no effect in the presence of amiloride and a low-chloride solution (-0.8 +/- 0.5 mV). This was also the case in the nasal epithelium of CF subjects (n = 4) carrying at least one G551D allele (-0.3 +/- 0.8 mV). Similarly, milrinone did not hyperpolarize the PD of either the tracheal (n = 6) or segmental (n = 6) airways of CF subjects (DeltaF508) when applied topically in vivo in the presence of amiloride, isoproterenol, or adenosine triphosphate (all 100 microM) in a low-chloride solution. These data do not support the use of milrinone to induce chloride secretion in CF airways in vivo.