Downlink Performance Analysis of MIMO Relaying Networks

In recent years, there has been an upsurge of interest in relay-augmented infrastructure-based networks. On the other hand, multiple-input-multiple-output (MIMO) wireless system becomes a hot topic for it can achieve significant increases in overall system performance. This paper gives a detailed analysis of downlink performance of MIMO relaying networks, in which different channel models and classic MIMO cellular system model with fixed relay are considered. Our results in single cell scenario show that when meeting effective relay system efficiency of 100%, the required relay SNR gain of 2-antenna system can be reduced to less than half of that with only one transceiver antenna. We also observe that MIMO is more tolerant to interference compared with the one-transceiver antenna system. After that, multi-hop architecture is researched and statistics figures out the tolerable number of hops which is supported in wireless communication with a view to real application. In addition, multi-cell scenario is also studied. Statistics results show that there is more 8 dB average spectral efficiency gain in a two-hop fixed relay 4 × 4 MIMO system than that in a SISO system. These results present significant indications in deployment and optimization of relay-based MIMO networks.     

Conjugated Polymer Based Nanoparticles as Dual‐Modal Probes for Targeted In Vivo Fluorescence and Magnetic Resonance Imaging

A facile strategy is developed to synthesize dual‐modal fluorescent‐magnetic nanoparticles (NPs) with surface folic acid by co‐encapsulation of a far‐red/near‐infrared (FR/NIR)‐emissive conjugated polymer (PFVBT) and lipid‐coated iron oxides (IOs) into a mixture of poly(lactic‐co‐glycolic‐acid)‐poly(ethylene glycol)‐folate (PLGA‐PEG‐FOL) and PLGA. The obtained NPs exhibit superparamagnetic properties and high fluorescence, which indicates that the lipid coated on IOs is effective at separating the conjugated polymer from IOs to minimize fluorescence quenching. These NPs are spherical in shape with an average diameter of ≈180 nm in water, as determined by laser light scattering. In vitro studies reveal that these dual‐modal NPs can serve as an effective fluorescent probe to achieve targeted imaging of MCF‐7 breast cancer cells without obvious cytotoxicity. In vivo fluorescence and magnetic resonance imaging results suggest that the NPs are able to preferentially accumulate in tumor tissues to allow dual‐modal detection of tumors in a living body. This demonstrates the potential of conjugated polymer based dual‐modal nanoprobes for versatile in vitro and in vivo applications in future.     

Multifunctional Mesoporous Silica Nanoparticles for Cancer‐Targeted and Controlled Drug Delivery

Multifunctional mesoporous silica nanoparticles are developed in order to deliver anticancer drugs to specific cancer cells in a targeted and controlled manner. The nanoparticle surface is functionalized with amino‐β‐cyclodextrin rings bridged by cleavable disulfide bonds, blocking drugs inside the mesopores of the nanoparticles. Poly(ethylene glycol) polymers, functionalized with an adamantane unit at one end and a folate unit at the other end, are immobilized onto the nanoparticle surface through strong β‐cyclodextrin/adamantane complexation. The non‐cytotoxic nanoparticles containing the folate targeting units are efficiently trapped by folate‐receptor‐rich HeLa cancer cells through receptormmediated endocytosis, while folate‐receptor‐poor human embryonic kidney 293 normal cells show much lower endocytosis towards nanoparticles under the same conditions. The nanoparticles endocytosed by the cancer cells can release loaded doxorubicin into the cells triggered by acidic endosomal pH. After the nanoparticles escape from the endosome and enter into the cytoplasm of cancer cells, the high concentration of glutathione in the cytoplasm can lead to the removal of the β‐cyclodextrin capping rings by cleaving the pre‐installed disulfide bonds, further promoting the release of doxorubicin from the drug carriers. The high drug‐delivery efficacy of the multifunctional nanoparticles is attributed to the co‐operative effects of folate‐mediated targeting and stimuli‐triggered drug release. The present delivery system capable of delivering drugs in a targeted and controlled manner provides a novel platform for the next generation of therapeutics.     

Investigation of Generalized SIFs of cracks in 3D piezoelectric media under various crack-face conditions

This paper investigates the influence of crack geometry, crack-face and loading conditions, and the permittivity of a medium inside the crack gap on intensity factors of planar and non-planar cracks in linear piezoelectric media. A weakly singular boundary integral equation method together with the near-front approximation is adopted to accurately determine the intensity factors. Obtained results indicate that the non-flat crack surface, the electric field, and the permittivity of a medium inside the crack gap play a crucial role on the behavior of intensity factors. The mode-I stress intensity factors (K_{\mathrm{I}}) for two representative non-planar cracks under different crack-face conditions are found significantly different and they possess both upper and lower bounds. In addition, K_{\mathrm{I}} for impermeable and semi-permeable non-planar cracks treated depends strongly on the electric field whereas those of impermeable, permeable, and semi-permeable penny-shaped cracks are identical and independent of the electric field. The stress/electric intensity factors predicted by permeable and energetically consistent models are, respectively, independent of and dependent on the electric field for the penny-shaped crack and the two representative non-planar cracks. Also, the permittivity of a medium inside the crack gap strongly affects the intensity factors for all crack configurations considered except for K_{\mathrm{I}} of the semi-permeable penny-shaped crack.     

Simulating secondary organic aerosol activation by condensation of multiple organics on seed particles

The conditions under which semivolatile organic gases condense were studied in a Teflon particle chamber by scanning mobility particle sizing (SMPS) of the resultant particles. Benzaldehyde, maleic and citraconic anhydrides, n-decane, trans-cinnamaldehyde, and citral were introduced in various combinations into a particle chamber containing either particle-free nitrogen or nitrogen with dry seed particles made out of sodium chloride, D-tartartic acid, ammonium sulfate, or 1,10-decanediol. No organic gas was allowed to reach its saturation point relative to the vapor pressure of its pure liquid in any experiment. In the absence of seed particles, organic aerosol particles formed by ternary nucleation when the sum of the individual organic saturation levels reached a threshold between 1.17 and 1.86. With seed particles present, particle sizes began to increase when the sum of organic saturation levels reached 1.0. This size increase corresponds to the establishment and activation of ternary organic layers on the "clean" seed particles, as predicted by absorption partitioning theory. The observed increases in particle volume depended on initial seed particle volume, indicating that either gas diffusion rates or chemical reactions were controlling the rate of uptake.     

Fermentation of meat with koji and commercial enzymes,and properties of its extract

This study was carried out in order to make the Japanese fermented meat sauce shishibishio. The fermentation mixtures (moromi) were prepared by mixing ground pork with salt at one of three levels (15, 20 or 25%), koji (rice fermented with Aspergillus oryzae) and pepper. Commercial enzymes, ie Alcalase or Pectinase 3S, were added in order to accelerate the proteolysis of the moromi. After 3 months of fermentation, counts of viable bacteria were below 300 cfu g^?1, and no coliforms was detected in any moromi. Shishibishio obtained after 3 months had an acceptable seasoning with high peptide and free amino acid content, and good hygienic quality; in particular, no unpleasant smell and taste was found. The addition of Alcalase or Pectinase 3S appreciably increased yield of shishibishio and protein recovery from moromi by accelerating the liquefaction and the proteolysis, resulting in the improvement of the sensory quality of the products. The highest yields were, respectively, 49.8 to 50.6%, collected from moromi in which we used 15% salt. Shishibishio with Alcalase had a higher peptide content but a lower total free amino acid content than that with Pectinase 3S. However, there was not much difference in the sensory evaluations for two enzyme treatments. Copyright © 2005 Society of Chemical Industry     

Slug Test Analysis in Vertical Cutoff Walls with Consideration of Filter Cake

In constructing a vertical cutoff wall, bentonite-water slurry is frequently used to maintain the stability of sidewalls during excavation before backfilling the trench with less permeable materials to complete the cutoff wall construction. This procedure leads to a thin but relatively impermeable layer, called a filter cake, on the excavation surface. The aim of this paper is to examine the effect of a filter cake on evaluating hydraulic conductivity of the cutoff wall backfill through a slug test analysis with the aid of the verified numerical program, Slug_3D. As an upper bound solution for evaluation of the hydraulic conductivity of the cutoff wall backfill, no-flux boundary conditions for the boundaries of cutoff walls are imposed to consider the effect of filter cakes. The type-curve method and modified line-fitting method are employed to reanalyze the case of EMCON/OWT, Inc., as an example. The previous analysis, without consideration of a filter cake, is compared with the current results that consider the filter cake to reveal the necessity of considering the effect of a filter cake in the slug test analysis. The comparison shows that the hydraulic conductivity of the cutoff wall backfill will be underestimated in a slug test analysis if the filter cake is not properly considered.     

Concurrent Delays and Apportionment of Damages

This paper focuses on the subject of concurrent delay from a general contractor (GC)-subcontractor perspective. When there is a concurrent delay by multiple subcontractors, or between the GC and other subcontractor(s), there has not been a uniform approach as to how the liquidated damages are apportioned. Previous research seems to ignore this issue. This paper first reviews some relevant court cases. Using a warehouse project as a case study, it then examines different practices that the GC could take in apportioning damages of concurrent delays to both himself/herself as well as to the responsible subcontractors. Results are very inconsistent between and within the apportionment practices. This supports an alternative hypothesis that apportionment is an important issue. Practitioners should specify which apportionment practice will be used and under what circumstances it will be applied in their subcontracts. Researchers may develop a more consistent and reliable approach for this type of apportionment.