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431.
Adri Chakraborty Rachelle Crescenzi Timaj A. Usman Andrea J. Reyna Maria E. Garza Sara Al-Ghadban Karen L. Herbst Paula M. C. Donahue Joseph M. Rutkowski 《International journal of molecular sciences》2022,23(18)
Lipedema is a disease with abnormally increased adipose tissue deposition and distribution. Pain sensations have been described in the clinical evaluation of lipedema, but its etiology remains poorly understood. We hypothesized that pain sensitivity measurements and ex vivo quantitation of neuronal cell body distribution in the skin would be lipedema stage-dependent, and could, thus, serve to objectively characterize neuropathic pain in lipedema. The pain was assessed by questionnaire and peripheral cutaneous mechanical sensitization (von-Frey) in lipedema (n = 27) and control (n = 23) consenting female volunteers. Dermal biopsies from (n = 11) Stages 1–3 lipedema and control (n = 10) participants were characterized for neuronal cell body and nociceptive neuropeptide calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF) distribution. Stage 2 or 3 lipedema participants responded positively to von Frey sensitization in the calf and thigh, and Stage 3 participants also responded in the arm. Lipedema abdominal skin displayed reduced Tuj-1+ neuronal cell body density, compared to healthy controls, while CGRP and NGF was significantly elevated in Stage 3 lipedema tissues. Together, dermal neuronal cell body loss is consistent with hyper-sensitization in patients with lipedema. Further study of neuropathic pain in lipedema may elucidate underlying disease mechanisms and inform lipedema clinical management and treatment impact. 相似文献
432.
Muhammad Hasnain Imran Ghani Seung Ryul Jeong Muhammad Fermi Pasha Sardar Usman Anjum Abbas 《计算机、材料和连续体(英文)》2023,74(1):783-799
Forecasting on success or failure of software has become an interesting and, in fact, an essential task in the software development industry. In order to explore the latest data on successes and failures, this research focused on certain questions such as is early phase of the software development life cycle better than later phases in predicting software success and avoiding high rework? What human factors contribute to success or failure of a software? What software practices are used by the industry practitioners to achieve high quality of software in their day-to-day work? In order to conduct this empirical analysis a total of 104 practitioners were recruited to determine how human factors, misinterpretation, and miscommunication of requirements and decision-making processes play their roles in software success forecasting. We discussed a potential relationship between forecasting of software success or failure and the development processes. We noticed that experienced participants had more confidence in their practices and responded to the questionnaire in this empirical study, and they were more likely to rate software success forecasting linking to the development processes. Our analysis also shows that cognitive bias is the central human factor that negatively affects forecasting of software success rate. The results of this empirical study also validated that requirements’ misinterpretation and miscommunication were the main causes behind software systems’ failure. It has been seen that reliable, relevant, and trustworthy sources of information help in decision-making to predict software systems’ success in the software industry. This empirical study highlights a need for other software practitioners to avoid such bias while working on software projects. Future investigation can be performed to identify the other human factors that may impact software systems’ success. 相似文献
433.
Silicon - An overview of the Passivated Emitter and Rear Totally Diffused (PERT) solar cell is presented, which is a member of Passivated Emitter and Rear Contact (PERC) family. Due to its... 相似文献
434.
Hamza Muhammad Nie Zhihong Aziz Mubashir Ijaz Nauman Fang Chuanfeng Ghani Muhammad Usman Ijaz Zain Noshin Sadaf Salman Muhammad 《Clean Technologies and Environmental Policy》2023,25(5):1699-1719
Clean Technologies and Environmental Policy - This article presents a comprehensive study on the geotechnical behavior of problematic expansive subgrade stabilized by guar gum (GG) biopolymer. In... 相似文献
435.
Ali Rashid Zafar Muhammad Manzoor Tareq Kim Woo Young Rashid Muhammad Usman Abbas Syed Zameer Zai Behzad Ahmed Ali Muddassir 《Journal of Mechanical Science and Technology》2022,36(5):2345-2353
Journal of Mechanical Science and Technology - In this study, the analysis is carried out to optimize in-gate position and size of riser for casting mold. The baseline size of riser for the casting... 相似文献
436.
Muhammad Irfan Wasi Ur Rehman Khan Sadiq Ullah Naveed Mufti Muhammad Fawad Khan Rizwan Ullah Usman Ali Fazal Muhammad Faisal Althobiani Mohammed Alshareef Shadi Alghaffari Saifur Rehman V. R. Shamji 《计算机系统科学与工程》2023,45(3):2693-2704
This paper presents, a novel cactus shaped frequency reconfigurable antenna for sub 10 GHz wireless applications. PIN diode is utilized as an electrical switch to achieve reconfigurability, enabling operation in four different frequency ranges. In the switch ON state mode, the antenna supports 2177–3431 and 6301–8467 MHz ranges. Alternatively, the antenna resonates within 2329–3431 and 4951–6718 MHz while in the OFF state mode. Radiation efficiency values, ranging from 68% to 84%, and gain values, ranging from 1.6 to 4 dB, in the operating frequency bands. the proposed antenna satisfy the practical requirements and expectations. The overall planner dimensions of the proposed antenna model is 40 × 21 mm2. Moreover, the measurement results from the prototype support the simulation results. Based on the frequency ranges supported by the antenna, it can be used for multiple wireless standards and services, including Worldwide interoperability and Microwave Access (WiMAX), Wireless Fidelity (Wi-Fi), Bluetooth, Long Term Evolution (LTE) and satellite communications. This increases its applicability for use in mobile terminals. 相似文献
437.
Atif Saleem Jingjie Chen Meng Liu Nian Liu Muhammad Usman Ke Wang Muhammad Haris Yuezhou Zhang Peng Li 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(15):2207348
Contamination of water resources by toxic metals and opportunistic pathogens remains a serious challenge. The development of nano-adsorbents with desired features to tackle this problem is a continuously evolving field. Here, magnetic mesoporous carbon nanospheres grafted by antimicrobial polyhexamethylene biguanidine (PHMB) are reported. Detailed mechanistic investigations reveal that the electrostatic stabilizer modified magnetic nanocore interfaced mesoporous shell can be programmatically regulated to tune the size and related morphological properties. The core–shell nano-adsorbent shows tailorable shell thickness (≈20–55 nm), high surface area (363.47 m2 g−1), pore volume (0.426 cm3 g−1), radially gradient pores (11.26 nm), and abundant biguanidine functionality. Importantly, the nano-adsorbent has high adsorption capacity for toxic thallium (Tl(I) ions (≈559 mg g−1), excellent disinfection against Staphylococcus aureus and Escherichia coli (>99.99% at 2 and 2.5 µg mL−1), ultrafast disinfection kinetics rate (>99.99% within ≈4 min), and remarkable regeneration capability when exposed to polluted water matrices. The Tl(I) removal is attributed to surface complexation and physical adsorption owing to open ended mesopores, while disinfection relies on contact of terminal biguanidines with phospholipid head groups of membrane. The significance of this work lies in bringing up effective synchronic water purification technology to combat pathogenic microorganisms and toxic metal. 相似文献
438.
Phthalonitrile polymers, under development at the Naval Research Laboratory, offer promise as high temperature, high performance composite matrix materials. A fully cured resin shows outstanding thermal stability with no evidence of a glass transition temperature or Tg up to 450°C, good mechanical properties, and is easily processed into void-free components. Phthalonitrile/glass fabric composite panels have been successfully fabricated by conventional consolidation of prepregged glass and by a more recently developed simplified process, resin infusion molding. Both processes can be used to produce panels with comparable mechanical properties. More important, flammability performance of these composites, evaluated in terms of specific optical density, combustion gases, heat release, and ignitability, excels over other state-of-the-art polymer/glass composites. This finding is significant given that overcoming flammability obstacles has been the main limiting factor for use of composites in marine applications. 相似文献