Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy

Photodynamic therapy(PDT)is a widely-used technology for cancer therapy,but conventional photosensitizers still face some drawbacks,such as hydrophobicity,inadequate pharmacokinetics,low cell/tissue specificity,and uncontrollable photodynamic performance during the therapeutic process.Herein,we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks(2D Zn-TCPP MOF)that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP.However,the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure.From the in vitro outcomes,the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments.Due to the acidic tumor microenvironment,the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser.This work offers a promising strategy to develop a next-generation photosensitizer.     

基于大数据驱动的配电网故障诊断与探索性预测模型

为了通过电网中记录的海量运行数据实现预测性维护、执行有效故障诊断和减少后续相关支出,以提高用户用电的可靠性和安全性,数据驱动模型在配电网络中变得至关重要.考虑以监控和数据采集系统 (SCADA)在实际中压配电网络中收集的超过６年的数据集为基础,由基于数据特征提取、时间窗、关联规则挖掘和关联分类器分析的流程进行试验评估并自动识别相关性,从故障中断前后时间窗建立预测Ｇ诊断模型并评估其应用潜力.试验结果表明,基于大数据驱动的电网预测模型潜力较不平衡,基于大数据驱动的电网诊断模型具有较高的诊断潜力和应用价值。     

A Simple Method for Calculating Settlement-Time Curves of PVD-Improved Deposits

Soil Mechanics and Foundation Engineering - A simple method has been proposed for calculating the settlement-time curves of deposits improved by prefabricated vertical drains (PVDs). This method...     

矿体等高线图应用问题初探

矿体等高线图是应用广泛的图件，同时似是而非的问题也随之出现。作者剖析了以往人们易持的偏见，论述了独特的新见解，为正确应用提供了科学方法。     

A Continuum Model for Heavy-electron Metal

The exact eigenstates of the Hamiltonian of a continuum model for heavy-electron metal are constructed by using the Bethe ansatz. The Bethe ansatz equations are obtained from the periodic boundary conditions. The results show that this system is also completely integrable.     

基于统一强度准则的预应力锚索极限承载力计算

基于统一强度理论和极限平衡原理，结合预应力锚索破裂面的形状，推导出一个能够考虑锚索破裂面形状、锚索的倾角、锚固体注浆压力、岩土体种类等因素的预应力锚索极限抗拔承载力计算公式。为验证计算公式的实用性，分别在软岩与硬岩中考虑不同的影响因素对理论计算结果与实测结果进行了比较。研究结果表明：随着加权系数的增大，锚索的极限抗拔力相应增加，但破裂面形状基本没有改变；锚索的极限抗拔力主要取决于锚索与浆体、锚固体与岩土体之间的界面强度，而破裂锥体部分岩土体所分担的抗拔力较小；在软岩中锚索的极限抗拔力和破裂锥体高度主要取决于锚固体与岩体的界面强度，受注浆压力的影响较小；在硬岩中注浆压力对锚索的极限抗拔力和破裂锥体高度都有着重要的影响，随着注浆压力的增大，极限抗拔力和破裂锥体高度相应增加。     

A Spectral Element Approximation to Price European Options with One Asset and Stochastic Volatility

We develop a Legendre quadrilateral spectral element approximation for the Black-Scholes equation to price European options with one underlying asset and stochastic volatility. A weak formulation of the equations imposes the boundary conditions naturally along the boundaries where the equation becomes singular, and in particular, we use an energy method to derive boundary conditions at outer boundaries for which the problem is well-posed on a finite domain. Using Heston’s analytical solution as a benchmark, we show that the spectral element approximation along with the proposed boundary conditions gives exponential convergence in the solution and the Greeks to the level of time and boundary errors in a domain of financial interest.     

大型内爬塔吊在超高层建筑施工中的应用

通过大型内爬塔吊在高层建筑中成功运用的实例,介绍了内爬塔吊及其专用顶升设备的基本原理,并对内爬塔吊与常规外附着落地式塔吊进行了简要的比较,可为受场地限制的高层建筑施工提供借鉴。     

黏土-水泥土接触面剪切特性试验研究

掌握黏土–水泥土接触面的剪切特性及土体运移规律是研究水泥土桩、墙等结构物承载和变形机理的关键。本文基于系列直剪试验研究黏土与不同粗糙度水泥土接触面的力学特性,以探究黏土–水泥土接触面抗剪强度、破坏规律及变形特性。结果表明：黏土–水泥土接触面的剪切破坏强度服从摩尔–库伦强度准则,接触面摩擦角随粗糙度的增加而增大,但增长速率逐渐减缓,而接触面粘聚力与黏土粘聚力大小相当;黏土–水泥土接触面的法向应变与剪切位移曲线整体表现为剪缩型,且剪缩量随法向应力和粗糙度的增加而增大。归一化的接触面强度有效系数Es随粗糙度的增加而增大,且当粗糙度R超过1.0 mm后,Es大于1.0,说明由于“被动阻力”的存在使得黏土–水泥土接触面的抗剪强度得到提升,从而出现大于黏土自身抗剪强度的情况。不同法向应力作用下,各接触面剪应力–剪切位移关系曲线均服从指数分布,据此建立了描述接触面粗糙度、剪应力、剪切位移、法向应力、摩擦角和粘聚力关系的复合指数模型,该模型对接触面剪应力–剪切位移关系曲线具有良好的拟合效果。此外,随着剪切过程的持续进行,剪切破坏区逐步由剪切前方扩展至剪切后方。研究结果对揭示黏土–水泥土接触面的力学特性及水泥土桩、墙等的设计具有参考和指导意义。