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21.
The kinetics of substrate removal by the liver and the resulting nonlinear changes in unbound fraction along the flow path at varying input drug concentrations were examined by a model simulation study. Specifically, we varied the binding association constant, KA, and the Michaelis-Menten constants (Km and Vmax) to examine the steady state drug removal (expressed as hepatic extraction ratio E) and changes in drug binding for (i) unienzyme systems and (ii) simple, parallel metabolic pathways; zonal metabolic heterogeneity was also added as a variable. At low KA, E declined with increasing input drug concentration, due primarily to saturation of enzymes; only small differences in binding were present across the liver. At high KA, a parabolic profile for E with concentration was observed; changes in unbound fraction between the inlet and the outlet of the liver followed in parallel fashion. Protein binding was the rate-determining step at low input drug concentrations, whereas enzyme saturation was the rate-controlling factor at high input drug concentration. Heterogeneous enzymic distribution modulated changes in unbound fraction within the liver and at the outlet. Despite marked changes in unbound fraction occurring within the liver for different enzymic distributions, the overall transhepatic differences were relatively small. We then investigated the logarithmic average unbound concentration and the length averaged concentration as estimates of substrate concentration in liver in the presence of nonlinear drug binding. Fitting of simulated data, with and without assigned random error (10%), to the Michaelis-Menten equation was performed; fitting was repeated for simulated data obtained with presence of a specific inhibitor of the high-affinity, anteriorly distributed pathway. Results were similar for both concentration terms: accurate estimates were obtained for anterior, high affinity pathways; an overestimation of parameters was observed for the lower affinity posteriorly distributed pathways. Improved estimations were found for posteriorly distributed pathways upon inhibition with specific inhibitors; with added random error, however, the improvement was much decreased. We applied the method for fitting of several sets of metabolic data obtained from rat liver perfusion studies performed with salicylamide (SAM) (i) without and (ii) with the presence of 2,6-dichloro-4-nitrophenol (DCNP), a SAM sulfation inhibitor. The fitted results showed that SAM sulfation was a high-affinity high-capacity pathway; SAM glucuronidation was of lower affinity but comparable capacity as the sulfation pathway, whereas SAM hydroxylation was of lower affinity and lower capacity. 相似文献
22.
One month following the Great Hanshin Earthquake of January 17, 1995, we conducted a survey of 173 hospitals in Aichi Prefecture to pinpoint problems related to their actual disaster-readiness and the medical backup systems in place to deal with such disasters. This study revealed that staff at 50% of the surveyed hospitals could reach the hospital within an hour, but that communication is almost entirely dependent on phone lines, suggesting that cordless/portable/mobile phones, radio systems, Internet, communications satellites and the like should be studied in the days to come for possible use as effective communication alternatives in times of disaster. Whereas 92% of the surveyed hospitals had manuals dealing with fire outbreaks, other areas were less well represented. For example, only 36.9% of surveyed hospitals had manuals for earthquakes, 31.7% had manuals for power outages and 14.2% had manuals to deal with flooding and water disasters. New manuals must be developed incorporating the key points garnered from experience (especially Hanshin) and be ready for use immediately. It is the time for each hospital to seriously rethink the measures it should take to deal with disasters. 相似文献
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先说明市内接入网的单位用户和住家用户两大类使用通信和电视、交互型和分配型业务的要求不相同,相应地对光纤传输的应用须作不同的考虑,文中认为;光纤从市内交换局直连办公大楼是合乎现实需要的,而对于居民住家,宜选用光纤连至路边或光纤与同轴结合和适当利用无源光网络等方案,俟将来时机成熟才实行光纤连至每一家,文末有概括总结,说明接入网不同于长途网,接入网的光纤系统可以使用常规单模光纤,工作于波长1.3μm,而光放大器和波分多路系统不是普遍需要,但光电子集成在光端机中是必要的。 相似文献
26.
McKinley P.K. Xu H. Esfahanian A.-H. Ni L.M. 《Parallel and Distributed Systems, IEEE Transactions on》1994,5(12):1252-1265
Multicast communication, in which the same message is delivered from a source node to an arbitrary number of destination nodes, is being increasingly demanded in parallel computing. System supported multicast services can potentially offer improved performance, increased functionality, and simplified programming, and may in turn be used to support various higher-level operations for data movement and global process control. This paper presents efficient algorithms to implement multicast communication in wormhole-routed direct networks, in the absence of hardware multicast support, by exploiting the properties of the switching technology. Minimum-time multicast algorithms are presented for n-dimensional meshes and hypercubes that use deterministic, dimension-ordered routing of unicast messages. Both algorithms can deliver a multicast message to m-1 destinations in [log 2 m] message passing steps, while avoiding contention among the constituent unicast messages. Performance results of implementations on a 64-node nCUBE-2 hypercube and a 168-node Symult 2010 2-D mesh are given 相似文献
27.
The dual-phase-lagging heat conduction equation is shown to be of one unique solution for a finite region of dimension n (n?2) under Dirichlet, Neumann or Robin boundary conditions. The solution is also found to be stable with respect to initial conditions. The work is of fundamental importance in applying the dual-phase-lagging model for the microscale heat conduction of high-rate heat flux. 相似文献
28.
南化大化肥硝铵库工程 ,于 2 0 0 0年 2月 15日开工 ,2 0 0 0年 10月 10日竣工 ,混凝土杯形基础 ,主体结构为单层、单跨、装配式的排架结构 ,30m预应力折线形屋架 ,大型屋面板 ,氯化聚乙烯防水卷材 ,建筑面积为 162 0m2 。氯化聚乙烯防水卷材是防水新型材料 ,由于防水性能好 ,施工方便 ,近几年得到了广泛的应用 ,在实际操作中往往由于施工人员对操作规程不甚了解 ,或虽有所了解 ,但没有认真对待 ,造成这样那样的质量问题 ,硝铵库作为一个储物库房 ,对防渗漏的要求高 ,那么施工中怎样避免出现渗漏现象 ,确保工程质量呢 ?1 做好施工准备检… 相似文献
29.
分析了WCDMA移动通信网网管系统管理框架,在此基础上提出采用公共对象请求代理体系结构(CORBA)建立网管系统信息模型的优势,给出WCDMA网管系统的信息模型,同时介绍了对象管理组(OMG)接口描述语言(IDL)。 相似文献
30.
Improving signal prediction performance of neural networks through multiresolution learning approach. 总被引:1,自引:0,他引:1
Yao Liang Xu Liang 《IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics》2006,36(2):341-352
In this paper, we extend the original work on multiresolution learning for neural networks, and present new developments on the multiresolution learning paradigm. The contributions of this paper include: (1) proposing a new concept and method of adjustable neural activation functions in multiresolution learning to improve neural network learning efficacy and generalization performance for signal predictions; (2) providing new insightful explanations for the multiresolution learning paradigm from a multiresolution optimization perspective; (3) exploring underlying ideas why the multiresolution learning scheme associated with adjustable activation functions would be more appropriate for the multiresolution learning paradigm; and (4) providing rigorous validations to evaluate the multiresolution learning paradigm with adjustable activation functions and comparing it with the schemes of multiresolution learning with fixed activation functions and traditional learning. This paper presents systematically new analytical and experimental results on the multiresolution learning approach for training an individual neural network model, demonstrates our integral solution on neural network learning efficacy, and illustrates the significant improvements on neural networks' generalization performance and robustness for nonlinear signal predictions. 相似文献