共焦回旋行波管注波互作用研究

共焦回旋行波管是一种采用新型高频结构的回旋器件,它能够工作在相对较高的工作模式,共焦波导通过衍射损耗抑制低阶模式,实现其模式选择特性。与此同时,由于共焦波导场分布的特点,采用共焦波导作为高频结构的回旋行波管的效率会有所降低。本文旨在研究共焦回旋行波管的注波互作用特点,针对共焦波导场分布的特性,在理论上采用特殊的电子注以提高其互作用效率。     

对应于Uq(sln)的弱Hopf代数的分类

首先给出A_n型非标准量子群X_q（A_n）的定义,通过替换X_q（A_n）的类群元,得到弱Hopf代数$\\mathfrak{m}{{X}_{q}}$（A_n）,然后探讨$\\mathfrak{m}{{X}_{q}}$（A_n）的结构并给出其Ext箭图.

     

以技术进步和管理创新推行节水降耗

介绍了公司在节水降耗方面不断推行科技进步,加强技术改造的同时,不断拓展管理思路,提高管理水平,取得了显著的经济效益和社会效益.     

张坝沟石灰石矿边坡控制爆破的现状

张坝沟石灰石矿长期采用光面爆破技术来减小爆破震动及后冲对固定边坡的危害.文中较详细的介绍了矿区地质条件、光面爆破的设计及施工中的问题,对倾斜孔非对心不耦合装药边坡爆破的效果进行了评价,建议采用多种控制目的的穿孔工作方法.     

政府工程中工程项目管理委托选择标准研究

我国政府工程中正在探索推行"代建制'即工程项目管理委托模式,但其中对项目管理单位的选择还没有统一详细的标准.在皿Ic推荐的工程咨询单位选择标准基础之上,通过分析我国"代建制"实施较早的上海、北京、武汉、重庆、深圳等城市的选择标准,构建了适合我国现状的选择标准体系.     

Bioanalysis of Oligonucleotide by LC–MS: Effects of Ion Pairing Regents and Recent Advances in Ion-Pairing-Free Analytical Strategies

Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are pivotal for preclinical and clinical investigations of therapeutic OGNs. Liquid chromatography–mass spectrometry (LC–MS) is now evolving into being the method of choice for the bioanalysis of OGNs. Ion paring reversed-phase liquid chromatography (IP-RPLC) has been widely used in sample preparation and LC–MS analysis of OGNs; however, there are technical issues associated with these methods. IP-free methods, such as hydrophilic interaction liquid chromatography (HILIC) and anion-exchange techniques, have emerged as promising approaches for the bioanalysis of OGNs. In this review, the state-of-the-art IP-RPLC–MS bioanalytical methods of OGNs and their metabolites published in the past 10 years (2012–2022) are critically reviewed. Recent advances in IP-reagent-free LC–MS bioanalysis methods are discussed. Finally, we describe future opportunities for developing new methods that can be used for the comprehensive bioanalysis of OGNs.     

The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain

Autophagy facilitates the degradation of organelles and cytoplasmic proteins in a lysosome-dependent manner. It also plays a crucial role in cell damage. Whether loganin affects autophagy in chronic constriction injury (CCI)-induced neuropathic pain remains unclear. We investigated the neuroprotective effect of loganin on the autophagic–lysosomal pathway in the rat CCI model. Sprague–Dawley rats were divided into sham, CCI, sham + loganin, and CCI + loganin. Loganin (5 mg/kg/day) was intraperitoneally injected once daily, and rats were sacrificed on day 7 after CCI. This study focused on the mechanism by which loganin modulates autophagic flux after CCI. CCI enhanced the autophagic marker LC3B-II in the ipsilateral spinal cord. The ubiquitin-binding protein p62 binds to LC3B-II and integrates into autophagosomes, which are degraded by autophagy. CCI caused the accumulation of p62, indicating the interruption of autophagosome turnover. Loganin significantly attenuated the expression of Beclin-1, LC3B-II, and p62. Double immunofluorescence staining was used to confirm that LC3B-II and p62 were reduced by loganin in the spinal microglia and astrocytes. Loganin also lessened the CCI-increased colocalization of both proteins. Enhanced lysosome-associated membrane protein 2 (LAMP2) and pro-cathepsin D (pro-CTSD) in CCI rats were also attenuated by loganin, suggesting that loganin improves impaired lysosomal function and autophagic flux. Loganin also attenuated the CCI-increased apoptosis protein Bax and cleaved caspase-3. Loganin prevents CCI-induced neuropathic pain, which could be attributed to the regulation of neuroinflammation, neuronal autophagy, and associated cell death. These data suggest autophagy could be a potential target for preventing neuropathic pain.     

面向星载海洋盐度探测应用的L波段综合孔径辐射计原理样机研制与试验研究

主被动联合微波成像仪(MICAP)是面向全球星载海洋盐度探测应用提出的一种新技术方案,由L, C, K频段辐射计及L波段散射计组成。其中L波段1维综合孔径辐射计是MICAP的核心,用以实现海洋盐度高精度观测。为了验证MICAP概念和性能,研制了一台地面原理样机并进行了试验研究。该文介绍了MICAP样机的L波段综合孔径辐射计子系统的研究与试验结果。首次推导了一种使用三阶量化均值对数字相关到模拟相关转换中的AD偏置误差进行校正的计算方法。该文的研究成果将为海洋盐度卫星MICAP及全球水循环卫星WCOM提供技术参考。     

求解线性互补问题的区间AOR方法

将AOR方法与区间理论相结合,给出了一种求解线性互补问题的区间方法——IAOR方法,并对系数矩阵为正对角的H矩阵时,证明了该算法收敛的几个充分性条件.最后给出了几个数值实例,通过与其它区间算法相比说明了该IAOR方法的有效性.     

Design of cavern blasting based on controllable parameters

After a thorough review of some controllable parameters, which included field investigations, cavern dimensions, explosive, rock strength etc., cut, contour, lifters and stoping holes were introduced for blasting cavern of nucleus submarine. These design were conducted using a U. Langefors and B. Kihlstrom theory. Supported by the Navy Cavern Project Foundation of China (02)