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排序方式: 共有393条查询结果,搜索用时 15 毫秒
1.
Karina Polak Beata Bergler-Czop Micha Szczepanek Kamila Wojciechowska Aleksandra Frtczak Norbert Kiss 《International journal of molecular sciences》2021,22(9)
Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Psoriasis Microbiome Index were developed in order to distinguish between psoriatic and healthy individuals. The “leaky gut syndrome” and bacterial translocation is considered by some authors as a triggering factor for the onset of the disease, as it promotes chronic systemic inflammation. The alterations were also found to resemble those in inflammatory bowel diseases, obesity and certain cardiovascular diseases. Microbiota dysbiosis, depletion in SCFAs production, increased amount of produced TMAO, dysregulation of the pathways affecting the balance between lymphocytes populations seem to be the most significant findings concerning gut physiology in psoriatic patients. The gut microbiota may serve as a potential response-to-treatment biomarker in certain cases of biological treatment. Oral probiotics administration as well as fecal microbial transplantation were most reported in bringing health benefits to psoriatic patients. However, the issue of psoriatic bacterial gut composition, its role and healing potential needs further investigation. Here we reviewed the literature on the current state of the relationship between psoriasis and gut microbiome. 相似文献
2.
Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
Beata Filip-Psurska Mateusz Psurski Artur Anisiewicz Patrycja Libako Ewa Zbrojewicz Magdalena Maciejewska Micha Chodyski Andrzej Kutner Joanna Wietrzyk 《International journal of molecular sciences》2021,22(5)
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)2D3 analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR. 相似文献
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Dora Szabo Zsolt Sarszegi Beata Polgar Eva Saghy Adam Nemeth Dora Reglodi Andras Makkos Aniko Gorbe Zsuzsanna Helyes Peter Ferdinandy Robert Herczeg Attila Gyenesei Attila Cziraki Andrea Tamas 《International journal of molecular sciences》2021,22(6)
Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI. 相似文献
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Beata Biaobok Janusz Trawczyski Wodzimierz Mita Mirosaw Zawadzki 《Applied catalysis. B, Environmental》2007,72(3-4):395-403
Ce- or Sr-doped LaCoO3 bulk perovskites were prepared by citric acid method as well as 10 wt.% of LaCoO3 was deposited on alumina carrier stabilized with lanthanum. Properties of prepared materials were characterized by determination of surface area, acid-basic properties and XRD, XPS, TPDO2, H2-TPR measurements as well as catalytic activity and selectivity for ethanol combustion was tested. It was found that substitution of La in LaCoO3 with either Sr or Ce has only small effect on its activity in ethanol combustion. Strontium inserted into LaCoO3 structure increases basic character of the perovskite surface as well as selectivity to acetaldehyde (ACA). Substitution of La with cerium has no effect on the concentration of basic sites and does not affect the selectivity to ACA. Activity of LaCoO3-based catalysts in ethanol combustion and their selectivity to ACA formation can be explained on the basis of the presence of both -oxygen species and sites with basic character on the material surface.
Acid-basic properties of supported LaCoO3 are dominated by acidic character of the carrier. Results of XPS and H2-TPR measurements of LaCoO3 supported on La–Al2O3 suggest that perovskite remains in strong interaction with carrier and probably is partially decomposed. Deposition of perovskite on stabilized carrier significantly increases the rate of ethanol combustion. 相似文献
7.
Fia?kowska E Kocerba W Pajdak-Stós A Klimek B Fyda J 《Water science and technology》2011,64(2):403-408
The novel idea of using rotifers Lecane inermis (Rotifera, Monogononta) as a tool to overcome activated sludge bulking generates an on-going need to study rotifer biology. The results of biological research on rotifers can serve to improve the method so that it can be most effective when applied in treatment plants. The aim of this study was to test the effect of temperature on four selected rotifer clones originating from different treatment plants. The rate of population development from a single individual (parthenogenetic female) during a 10-day experiment was measured at three temperatures: 8, 15 and 20 degrees C. The temperatures used reflect the annual temperature distribution in the majority of municipal wastewater treatment plants in the temperate zone. The growth rate coefficient (r) and doubling time (tD) were calculated for each clone. Under the most favourable conditions (20 degrees C), rvalues varied between 0.41 and 0.47 d and doubling time between 1.5 and 1.7 d. At a temperature of 15 degrees C, the doubling time was approximately two times longer (2.5-3.4 d). The strongest intraspecific variations were observed at the lowest temperature of 8 degrees C. At this temperature, one of the clones almost failed to proliferate, and another exhibited a doubling time of 7.9 d. The doubling times were a few times greater for the remaining two clones (60 d for Lk1, 33.3 d for Lk4). These results could be very useful in predicting the chances that the rotifers would survive in a biological reactor in a wastewater treatment plant at the temperatures used in these reactors. 相似文献
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9.
Peter VialAuthor Vitae Beata WysockiAuthor VitaeTadeusz WysockiAuthor Vitae Montserrat RosAuthor VitaeDavid StirlingAuthor Vitae 《Computers & Electrical Engineering》2012,38(4):994-1009
This study investigates the effect of multiple sources using STS across a Time-Hopping-PPM Modulation that is over an UWB Saleh-Valenzuela channel with each source using two transmit antennas. We model and analyze this system, showing that the presence of such MAI results in a significant degradation in BER performance. Simulation results show that for strong signal strength of interfering MAI signals degradation in BER performance is observed for the cases where we have five and 10 distinct MAI sources present when using Walsh-Hadamard thirty two chip spreading sequences. Using simulation, we investigate the use of other sets of orthogonal spreading sequences with improved cross correlation properties and find that for some sequences a significant improvement is seen compared to Walsh-Hadamard sequences when they are similarly misaligned. We show that MAI degrades the BER performance of such systems and that selection of improved cross correlation spreading code sequence sets improves BER. 相似文献
10.
In the Fe–30Ni alloy investigated a martensitic transformation can occur both during quenching or plastic deformation. Martensite formed during plastic deformation, depending on the thermo-mechanical treatment applied, exhibits a different morphology from that achieved during quenching and forms the so-called composite-like structure. The morphology and volume fraction of martensite depends both on strain and temperature. In the present studies Fe–30Ni alloy was deformed by monotonic rolling in one path and perpendicular rolling in the temperature range MD–MS. The aim of the investigations was a determination of martensite volume fraction depending on the strain and temperature. To examine the influence of strain, the alloy was deformed by rolling in one path or perpendicular rolling at a temperature of − 30 °C, in the strain range of 10–30%. The dependence of temperature was investigated by rolling with 30% strain in a temperature range from − 30 °C to − 80 °C. The variants of thermo-mechanical treatment performed enabled us to achieve different martensite morphologies and volume fractions. Microstructural analysis was performed by means of light microscopy and transmission electron microscopy. The results of quantitative microstructural analysis of martensite and retained austenite volume fractions formed in different thermo-mechanical treatments were compared with those obtained by magnetic measurements. The fraction of deformation-induced martensite determined varied from 2% to 86%. The partial volume fractions VVMF of martensite formed in different deformation directions were also determined. It was found that the influence of the temperature on the martensite volume fraction is more pronounced than the influence of strain. 相似文献