Thermal stability of the αZn–Mg2Zn11 and αZn–βAl eutectics obtained by Bridgman growth

The thermal stability of rod-like Zn–Mg2Zn11 and lamellar Zn–Al eutectics obtained by Bridgman growth of Zn–3.1 wt% Mg and Zn–5 wt% Al has been studied for soaking times up to 10 h at 300 and 350°C, respectively. Two-dimensional coarsening resulted for Zn–Mg2Zn11 grown at 0.5 and 1 mm s-1 while fault migration was operative for lamellar Zn–Al grown at 0.1 and 1 mm s-1. Hardness decreased with increased soaking time according to a Hall–Petch relationship with mean interphase spacing and the values H0 and kY accord well with the values obtained from the Hall–Petch relationship for HV of as-solidified Zn–Mg2Zn11 and Zn–Al with eutectic interphase spacing, respectively. © 1998 Chapman & Hall     

A rapid computational filter for predicting the rate of human renal clearance

In silico models that predict the rate of human renal clearance for a diverse set of drugs, that exhibit both active secretion and net re-absorption, have been produced using three statistical approaches. Partial Least Squares (PLS) and Random Forests (RF) have been used to produce continuous models whereas Classification And Regression Trees (CART) has only been used for a classification model. The best models generated from either PLS or RF produce significant models that can predict acids/zwitterions, bases and neutrals with approximate average fold errors of 3, 3 and 4, respectively, for an independent test set that covers oral drug-like property space. These models contain additional information on top of any influence arising from plasma protein binding on the rate of renal clearance. Classification And Regression Trees (CART) has been used to generate a classification tree leading to a simple set of Renal Clearance Rules (RCR) that can be applied to man. The rules are influenced by lipophilicity and ion class and can correctly predict 60% of an independent test set. These percentages increase to 71% and 79% for drugs with renal clearances of < 0.1 ml/min/kg and > 1 ml/min/kg, respectively. As far as the authors are aware these are the first set of models to appear in the literature that predict the rate of human renal clearance and can be used to manipulate molecular properties leading to new drugs that are less likely to fail due to renal clearance.     

Tactical combat movements: inter-individual variation in performance due to the effects of load carriage

An examination into the effects of carried military equipment on the performance of two tactical combat movement simulations was conducted. Nineteen Airfield Defence Guards performed a break contact (five 30-m sprints) and a fire and movement simulation (16 6-m bounds) in five load conditions (10–30 kg). Heavier loads significantly increased movement duration on the break contact (0.8%/kg load) and fire and movement (1.1%/kg). Performance deterioration was observed from the beginning to the end of the series of movements (bounds or sprints) with deterioration becoming significantly greater in heavier load conditions. Inter-individual variation between slower and faster participants showed a range in load effects; 0.6, 0.8%/kg for fast and 1.0, 1.4%/kg for slow (break contact, fire and movement, respectively). Velocity profiles revealed that the initial acceleration and peak velocity were the primary determinants of performance. As the duration of these tactical combat movements reflects periods of heightened vulnerability, these findings highlight important implications for commanders.

Practitioner Summary: Increasing amounts of carried military equipment impairs the performance of tactical combat movements. Examination of inter-individual variation in velocity profiles identified that the initial acceleration and the peak velocity achieved during sprints and bounds are key determinants of overall performance.     

On the elastic modulus degradation in continuum damage mechanics

To measure accurately the elastic modulus of a metal, E, can be a difficult task when a specimen undergoes plastic strains. Moreover, some failure criteria, such as those associated with Continuum Damage Mechanics, require the change of elastic modulus with strain to define a measure of damage, D, in a material or structure. Thus, it is important to assess the possible geometrical influence of a specimen on the measurement of the elastic modulus at different deformation levels. It is shown in this article, with the aid of a numerical simulation, that any plastic strains induce important geometrical effects in the evaluation of E, which have a significant influence on the evaluation of the scalar damage parameter, D.     

Local Dynamic Stability Assessment of Motion Impaired Elderly Using Electronic Textile Pants

A clear association has been demonstrated between gait stability and falls in the elderly. Integration of wearable computing and human dynamic stability measures into home automation systems may help differentiate fall-prone individuals in a residential environment. The objective of the current study was to evaluate the capability of a pair of electronic textile (e-textile) pants system to assess local dynamic stability and to differentiate motion-impaired elderly from their healthy counterparts. A pair of e-textile pants comprised of numerous e-TAGs at locations corresponding to lower extremity joints was developed to collect acceleration, angular velocity and piezoelectric data. Four motion-impaired elderly together with nine healthy individuals (both young and old) participated in treadmill walking with a motion capture system simultaneously collecting kinematic data. Local dynamic stability, characterized by maximum Lyapunov exponent, was computed based on vertical acceleration and angular velocity at lower extremity joints for the measurements from both e-textile and motion capture systems. Results indicated that the motion-impaired elderly had significantly higher maximum Lyapunov exponents (computed from vertical acceleration data) than healthy individuals at the right ankle and hip joints. In addition, maximum Lyapunov exponents assessed by the motion capture system were found to be significantly higher than those assessed by the e-textile system. Despite the difference between these measurement techniques, attaching accelerometers at the ankle and hip joints was shown to be an effective sensor configuration. It was concluded that the e-textile pants system, via dynamic stability assessment, has the potential to identify motion-impaired elderly.     

Synthesis and characterisation of alumina pillared Texas montmorillonite and determination of the effective Keggin ion charge

Controlled calcination of Texas montmorillonite has allowed production of a range of materials of cation exchange capacity from 70 mequiv./100 g dry clay to virtually zero. Pillaring of these with Chlorhydrol precursor solution has then provided a family of materials of pillar density ranging from about one per six unit cells to zero. The analytical technique based on isomorphous metal dilution (IMD) that follows pillaring is validated. The results provide a consistent value for the precursor (Keggin) ion charge, in the conditions normally used, of 3.15±0.10 rather than the formal value of 7. An approach to the attainment of pillar densities consistent with the introduction of shape/size selectivity on pillared layered materials is outlined.