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81.
Clark T. Hung Jennifer Racine-Avila Matthew J. Pellicore Roy Aaron 《International journal of molecular sciences》2022,23(7)
A prominent feature of the skeleton is its ability to remodel in response to biophysical stimuli and to repair under varied biophysical conditions. This allows the skeleton considerable adaptation to meet its physiological roles of stability and movement. Skeletal cells and their mesenchymal precursors exist in a native environment rich with biophysical signals, and they sense and respond to those signals to meet organismal demands of the skeleton. While mechanical strain is the most recognized of the skeletal biophysical stimuli, signaling phenomena also include fluid flow, hydrostatic pressure, shear stress, and ion-movement-related electrokinetic phenomena including, prominently, streaming potentials. Because of the complex interactions of these electromechanical signals, it is difficult to isolate the significance of each. The application of external electrical and electromagnetic fields allows an exploration of the effects of these stimuli on cell differentiation and extra-cellular matrix formation in the absence of mechanical strain. This review takes a distinctly translational approach to mechanistic and preclinical studies of differentiation and skeletal lineage commitment of mesenchymal cells under biophysical stimulation. In vitro studies facilitate the examination of isolated cellular responses while in vivo studies permit the observation of cell differentiation and extracellular matrix synthesis. 相似文献
82.
人在长时间运动后的疲劳和体内存储的肌糖原的消耗密切相关,因此运动后糖原合成的速度是短时间内运动恢复的关键因素。接下来的实验有效地研究了运动后补充的营养成分对于再次运动时耐力表现的影响。 相似文献
83.
Aaron Gosling Geoff W. Stevens Andrew R. Barber Sandra E. Kentish Sally L. Gras 《Food chemistry》2010
The production of prebiotic galactooligosaccharides (GOS) by the β-galactosidase catalysed conversion of lactose has become commercially important. Yet it remains a challenge to sufficiently understand the structure and activity of β-galactosidase, to increase the efficiency of transgalactosylation and GOS production and to improve the quality of GOS products in a rational way. This review covers the broad but related aspects of GOS synthesis including: the structure and reaction mechanism of β-galactosidase, factors effecting yield and productivity of GOS synthesis systems, the structure of GOS products, models for the kinetics of GOS synthesis and reactor configurations for GOS synthesis. It aims to couple recent discoveries with established knowledge to enhance understanding of the complex biochemistry of GOS synthesis. 相似文献
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85.
Thomas J. Siller Alma Rosales John Haines Aaron Benally 《Canadian Metallurgical Quarterly》2009,135(3):102-108
The development of engineering students’ professional skills has gained considerable national attention from Accreditation Board for Engineering and Technology, the National Academy of Engineering, ASCE, and other constituents. There is little debate that these professional skills are necessary. Engineering programs have tried many approaches to develop these skills in the undergraduate programs. Colorado State University (CSU) has developed a new approach modeled on the type of professional development that occurs in the professional environment. This new Professional Learning Institute (PLI) provides students with a broad array of workshops, presentations, and experiential opportunities addressing the areas of cross cultural communication and teamwork, innovation, leadership, ethics, and public service. This program introduces students to the concept of professional development through required extracurricular activities, includes minimum requirements along with requirements to earn certificates in specialty areas for motivated students. The majority of offerings in the PLI are presented by leaders from the engineering profession who have teamed with CSU to provide high quality programs for our students. 相似文献
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88.
Raffay Hamid Siddhartha Maddi Aaron Bobick Charles Isbell 《Artificial Intelligence》2009,173(14):1221-1244
Formalizing computational models for everyday human activities remains an open challenge. Many previous approaches towards this end assume prior knowledge about the structure of activities, using which explicitly defined models are learned in a completely supervised manner. For a majority of everyday environments however, the structure of the in situ activities is generally not known a priori. In this paper we investigate knowledge representations and manipulation techniques that facilitate learning of human activities in a minimally supervised manner. The key contribution of this work is the idea that global structural information of human activities can be encoded using a subset of their local event subsequences, and that this encoding is sufficient for activity-class discovery and classification.In particular, we investigate modeling activity sequences in terms of their constituent subsequences that we call event n-grams. Exploiting this representation, we propose a computational framework to automatically discover the various activity-classes taking place in an environment. We model these activity-classes as maximally similar activity-cliques in a completely connected graph of activities, and describe how to discover them efficiently. Moreover, we propose methods for finding characterizations of these discovered classes from a holistic as well as a by-parts perspective. Using such characterizations, we present a method to classify a new activity to one of the discovered activity-classes, and to automatically detect whether it is anomalous with respect to the general characteristics of its membership class. Our results show the efficacy of our approach in a variety of everyday environments. 相似文献
89.
Seong-Joon Baek Aaron Park Jinyoung Kim Aigou Shen Jiming Hu 《Chemometrics and Intelligent Laboratory Systems》2009,98(1):24-30
In this paper, we consider a new background elimination method for Raman spectra. The proposed method is based on peak detection, smoothing, and interpolation. Since the background is usually slowly varying with respect to wavelength, we could estimate the background by eliminating significant peaks. For this purpose, we seek the peaks by inspecting the smoothed derivative of a given spectrum. After clipping out the corresponding peak regions, we estimate the background by applying a modified linear interpolation. Then the background is eliminated from the measured Raman spectrum by simple subtraction. The experimental results showed that the proposed method gave satisfactory results for real Raman spectra as well as synthetic data. As the proposed method requires no prior knowledge of spectrum, we expect that the method could be applied to other spectral data as well. 相似文献
90.
Chander Shekhar Sharma Amanda Ates Poulson Joseph Kamlesh A. Soni M. Wes Schilling Aaron Kiess 《International Journal of Food Science & Technology》2013,48(7):1410-1415
The efficacy of lauric arginate (LAE) on Salmonella survivability in ground chicken containing 9.8% fat was determined under refrigerated storage. The effect of LAE treatments on total aerobes, pH and objective colour were also assessed in ground chicken. LAE was highly effective against Salmonella in 0.1% peptone with no detectable survivors following treatment with 200 ppm and 400 ppm of LAE. No difference existed (P > 0.05) in the growth of Salmonella and total aerobes after treatment with 200 and 400 ppm of LAE in ground chicken inoculated with a four strain mixture of Salmonella. At these concentrations, LAE did not exhibit any treatment effect on the pH and colour of ground chicken (P > 0.05). In conclusion, although LAE possesses strong inhibitory (P < 0.05) effect against Salmonella in suspension in 0.1% peptone water, no inhibitory (P > 0.05) effect on growth of Salmonella was observed in ground chicken at the currently approved levels of 200 ppm of LAE. 相似文献