The authors compared in a controlled clinical study two groups of patients after a first renal transplantation treated by triple drug immunosuppressive therapy. In a group of 31 patients the triple combination comprised Sandimmune Neoral. In the control group there were 30 patients who received Sandimmune. No differences were found between the two groups as regards the effectiveness of this treatment and the authors did not confirm a lower incidence of rejections described in patients treated with Sandimmune Neoral. They confirmed, however, a lower interindividual variability of Cy-A levels assessed specifically in patients treated with Sandimmune Neoral. 相似文献
当前处理器由于较高的能量消耗,导致处理器热量散发的提高及系统可靠性的降低,同时任务实际运行中的错误也降低了系统的可靠性.因此同时满足节能性及容错性已经成为目前计算机领域较为关心的问题.提出的调度算法针对实时多处理器计算环境,以执行时间最短的任务优先调度为基础,结合其他有效技术(共享空闲时间回收及检查点技术),使得实时任务在其截止期内完成的同时,能够动态地降低整个系统的能量消耗及动态容错.针对独立任务集及具有依赖关系的任务集,提出两种算法:STFBA1及STFBA2(shortest task first based algorithm).通过实验与目前所知的有效算法相比,算法具有更好的性能(调度长度及能量消耗)及较低的通信时间复杂度. 相似文献
The objective of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using hydroxypropyl methyl cellulose (HPMC) hydrogels. HPMC hydrogels containing poly ethylene glycol (PEG) as cross-links have been prepared by reacting HPMC sodium salt with polyethylene glycol dichloride.
The effect of cross-linking agent on swelling behavior of HPMC-PEG hydrogels, were investigated. Swelling parameters such as equilibrium degree of swelling, swelling ratio and network parameter such as molecular mass between cross-links (Mc) were determined. The cross-linking concentrations were 0.5%, 1%, 1.5%, and 2% (based on weight of HPMC). The equilibrium swelling ratio (Q) of cross-linked HPMC hydrogels increases from 13.2 to 27.1 as the cross-linker percentage increases from 0.5% to 2%. 5-Aminosalicylic acid (5-ASA) was used as a model of an anti-inflammatory drug. Cross-linked HPMC hydrogels were found to be a promising drug delivery system for the drugs to be delivered to the colon. 相似文献
It is a very difficult task for the researchers to find the exact solutions to
mathematical problems that contain non-linear terms in the equation. Therefore, this article
aims to investigate the viscous dissipation (VD) effect on the fractional model of Jeffrey
fluid over a heated vertical flat plate that suddenly moves in its own plane. Based on the
Atangana-Baleanu operator, the fractional model is developed from the fractional
constitutive equations. VD is responsible for the non-linear behavior in the problem. Upon
taking the Laplace and Fourier sine transforms, exact expressions have been obtained for
momentum and energy equations. The influence of relative parameters on fluid flow and
temperature distribution is shown graphically. As special cases, and for the sake of
correctness, the corresponding results for second-grade fluid and Newtonian viscous fluid
are also obtained. It is interesting to note that fractional parameter α provides more than
one line as compared to the classical model. This effect represents the memory effect in the
fluid which is not possible to elaborate by the classical model. It is also worth noting that
the temperature profile of the generalized Jeffrey fluid rises for higher values of Eckert
number which is due to the enthalpy difference of the boundary layer. 相似文献
Universal access from a handheld device (such as a PDA, cell phone) at any time or anywhere is now a reality. Ubicomp Assistant
(UA) (Sharmin et al. in Proceedings of the 21st annual ACM symposium on applied computing (ACM SAC 2006), Dijon, France, pp
1013–1017, 2006) is an integral service of MARKS (Sharmin et al. in Proceedings of the third international conference on information
technology: new generations (ITNG 2006), Las Vegas, Nevada, USA, pp 306–313, 2006). It is a middleware developed for handheld
devices, and has been designed to accommodate different types of users (e.g., education, healthcare, marketing, or business).
This customizable service employs the ubiquitous nature of current short range, low-power wireless connectivity and readily
available, low-cost lightweight mobile devices. These devices can reach other neighbouring devices using a free short-range
ad hoc network. To the best of the authors’ knowledge, the UA service is the only service designed for these devices. This
paper presents the details of Ubi-App, a ubiquitous application for universal access from any handheld device, which uses
UA as a service. The results of a usability test and performance evaluation of the prototype show that Ubi-App is useful,
easy to use, easy to install, and does not degrade the performance of the device. 相似文献
Software design patterns are well-known solutions for solving commonly occurring problems in software design. Detecting design patterns used in the code can help to understand the structure and behavior of the software, evaluate the quality of the software, and trace important design decisions. To develop and maintain a software system, we need sufficient knowledge of design decisions and software implementation processes. However, the acquisition of knowledge related to design patterns used in complex software systems is a challenging, time-consuming, and costly task. Therefore, using a suitable method to detect the design patterns used in the code reduces software development and maintenance costs. In this paper, we proposed a new method based on conceptual signatures to improve the accuracy of design pattern detection. So we used the conceptual signatures based on the purpose of patterns to detect the patterns’ instances that conform to the standard structure of patterns, and cover more instances of patterns’ variants and implementation versions of the patterns and improve the accuracy of pattern detection. The proposed method is a specific process in two main phases. In the first phase, the conceptual signature and detection formula for each pattern is determined manually. Then in the second phase, each pattern in the code is detected in a semi-automatic process using the conceptual signature and pattern detection formula. To implement the proposed method, we focused on GoF design patterns and their variants. We evaluated the accuracy of our proposed method on five open-source projects, namely, Junit v3.7, JHotDraw v5.1, QuickUML 2001, JRefactory v2.6.24, and MapperXML v1.9.7. Also, we performed our experiments on a set of source codes containing the instances of GoF design patterns’ variants for a comprehensive and fair evaluation. The evaluation results indicate that the proposed method has improved the accuracy of design pattern detection in the code.
Multimedia Tools and Applications - Automatic Emotion Speech Recognition (ESR) is considered as an active research field in the Human-Computer Interface (HCI). Typically, the ESR system is... 相似文献
This paper extends hybrid-type optimization models of genetic algorithm adaptive network-based fuzzy inference system (GA-ANFIS) for predicting the soil permeability coefficient (SPC) of different types of soil. In these models, GA optimizes parameters of a subtractive clustering technique that controls the structure of the ANFIS model’s fuzzy rule base. Simultaneously, a hybrid leaning algorithm is employed in the ANFIS, as a trained fuzzy inference system (FIS), which optimally determines the parameter sets of the examined FISs in ANFIS. Using an updated large database of SPCs consisting of 338 fine-grained, 178 mixed and 94 granular soil samples, GA-ANFIS framework constructs different models of predicting the permeability coefficient of respectively fine-grained, mixed and granular soils. A fuzzy C-mean technique has been used to cluster the entire data samples of each type of soil and divide them uniformly into training and testing data sets. Different prediction models of SPC have been trained and tested for each of the three soil types, and the appropriate models have been selected. The selected models have been compared with ANN and modified-by-GA empirical prediction models. Results show that the constructed GA-ANFIS models outperform the other models in terms of the prediction accuracy and the generalization capability. 相似文献
In this paper a novel multiresolution human visual system and statistically based image coding scheme is presented. It decorrelates
the input image into a number of subbands using a lifting based wavelet transform. The codec employs a novel statistical encoding
algorithm to code the coefficients in the detail subbands. Perceptual weights are applied to regulate the threshold value
of each detail subband that is required in the statistical encoding process. The baseband coefficients are losslessly coded.
An extension of the codec to the progressive transmission of images is also developed. To evaluate the performance of the
coding scheme, it was applied to a number of test images and its performance with and without perceptual weights is evaluated.
The results indicate significant improvement in both subjective and objective quality of the reconstructed images when perceptual
weights are employed. The performance of the proposed technique was also compared to JPEG and JPEG2000. The results show that
the proposed coding scheme outperforms both coding standards at low compression ratios, while offering satisfactory performance
at higher compression ratios. 相似文献