Gated MaxWIP: A strategy for controlling multistage production systems

This study considers serial production systems with exponential processing times. The systems are balanced, i.e. all resources have the same production rate capacity. Preceding the system there is a 'gate' set to regulate the flow of material into the system. A control strategy directs each resource when to work or stay idle. The trade-off is between throughput (TP) and work-in-process (WIP). G-MaxWIP is a production control strategy allowing resources, except for the gate, to work unconstrained. The gate 'shuts' once the system's WIP reaches a maximum allowable level. We study the properties of G-MaxWIP and compare it to 'simple pull' and CONWIP. Our main findings are: G-MaxWIP is superior to simple pull. For any simple pull system operating a fixed set of resources it is possible to find G-MaxWIP systems that operate the same resources with less WIP while maintaining the same (or higher) TP. G-MaxWIP is superior to CONWIP. For any CONWIP system operating a fixed set of resources it is possible to find G-MaxWIP systems that operate the same resources with less WIP while maintaining the same (or higher) TP.     

Carvacrol and trans-Cinnamaldehyde Reduce Clostridium difficile Toxin Production and Cytotoxicity in Vitro

Clostridium difficile is a nosocomial pathogen that causes a serious toxin-mediated enteric disease in humans. Reducing C. difficile toxin production could significantly minimize its pathogenicity and improve disease outcomes in humans. This study investigated the efficacy of two, food-grade, plant-derived compounds, namely trans-cinnamaldehyde (TC) and carvacrol (CR) in reducing C. difficile toxin production and cytotoxicity in vitro. Three hypervirulent C. difficile isolates were grown with or without the sub-inhibitory concentrations of TC or CR, and the culture supernatant and the bacterial pellet were collected for total toxin quantitation, Vero cell cytotoxicity assay and RT-qPCR analysis of toxin-encoding genes. The effect of CR and TC on a codY mutant and wild type C. difficile was also investigated. Carvacrol and TC substantially reduced C. difficile toxin production and cytotoxicity on Vero cells. The plant compounds also significantly down-regulated toxin production genes. Carvacrol and TC did not inhibit toxin production in the codY mutant of C. difficile, suggesting a potential codY-mediated anti-toxigenic mechanism of the plant compounds. The antitoxigenic concentrations of CR and TC did not inhibit the growth of beneficial gut bacteria. Our results suggest that CR and TC could potentially be used to control C. difficile, and warrant future studies in vivo.     

Fermented milk obtained with kefir grains as an ingredient in breadmaking

The objectives of this research were to study the effect of the addition of lyophilised kefir milk to premixes for household production of bread and evaluate the quality attributes of them. Four lyophilised samples were obtained from the followings: skim milk, acidified skim milk, fermented skim milk and neutralised fermented skim milk. Breads were prepared with commercial wheat flour, lyophilised milk samples and yeast through a straight dough process. Quality was assessed through loaf volume, crumb porosity and moisture, crumb texture and crust colour. Changes in texture and starch recrystallisation by X‐ray diffractometry were determined after 1 and 3 days of storage at room temperature. Breads with acidified milks showed the highest specific volumes and crumbs with the best texture properties. Crystallinity in bread with fermented milks was higher than for skim milk sample. This would indicate that there would be a certain effect of the type of milk processing on the promotion of starch retrogradation.     

Enriching our theoretical repertoire: the role of evolutionary psychology in technology acceptance

Information systems (IS) research has drawn heavily on social and cognitive psychology to explain technology adoption. Indeed, the many variations of the technology acceptance model all share these same theoretical foundations. Focusing exclusively on the socio-cognitive lens can lead to overlooking enhanced explanations of technology acceptance, such that new theoretical perspectives may be warranted. In this qualitative grounded theory study, we discovered how the lens of evolutionary psychology, as embodied in the Four-Drive model, was helpful in understanding technology acceptance across three organizational sites. We contend that evolutionary psychology is an important addition to the theoretical repertoire of IS researchers, and propose including ‘evolved psychological mechanisms’ within traditional models of technology acceptance.     

On the Properties of Fuzzy Switching Functions

Abstract

A strictly binary approach to the treatment of switching circuits today is not always adequate to describe systems in the real world. This approach is partly due, to the relative simplicity of designing binary switching systems, and to the fact that basic switching modules in common use are two-positional. Consequently, every variable in Boolean logic is assumed to be two-valued. However, because of real-world constraints, the attributes of system variables are often ambiguously defined. In other words, quite often variables might have values other than falsehood and truth. Cases with such attributes arise, for example in artifical intelligence and related subjects. Ever since Zadeh introduced the idea of fuzzy set theory [11 by utilizing the concept of membership grade, a number of authors have been concerned with the analysis and applications of fuzzy models. Especially, the relation of fuzzy to switching systems have been discussed in [2]–[12] and by other researchers in relation to other topics.

In this paper we are concerned with the study of fuzzy switching functions and their properties. Special attention is devoted to their minimization, enumeration, and their application to Boolean static hazard detection.     

Conductive Recyclable Organogel Composites

As the use of automation in industry accelerates, the development of flexible, electrically conducting materials with the requisite environmental resilience for impact‐resistant sensors, foldable electronics, and electrostatic shielding are needed; simultaneously, recyclability for these materials remains a crucial attribute. Traditional conductive stretchable materials, such as rubbers, are not recyclable, and hydrogel materials have limited applications due to water evaporation and operating temperature range. Comparatively, organogels can be formulated with enhanced tunability, matrix recyclability, and the ability to support many conductive fillers. Here, rheology, mechanical testing, and electrochemical impedance spectroscopy (EIS) characterize the nanoscale interactions between carbon fillers, the liquid phase, and the network matrix in hemiaminal dynamic covalent network (HDCN) organogels. HDCN chemical equilibria are shown to strongly influence macroscopic gel properties, while HDCN composites exhibit very high conductivities up to 9.95 mS cm^?1 appropriate for sensing applications, demonstrating promise as recyclable alternatives for conductive stretchable materials.     

Comparative studies on the electrochemical and physicochemical behaviour of three different benzimidazole motifs as corrosion inhibitor for mild steel in hydrochloric acid

This paper examines the anticorrosion characteristics of three different benzimidazole derivatives towards mild steel in 0.5?M hydrochloric acid at temperature ranges from 303 to 323?K. The benzimidazole derivatives used for the screening studies are 2-(2-methyl-1H-benzimidazol-1-yl) acethydrazide (EMBAH), 2-(2-ethyl-1H-benzimidazol-1-yl) acethydrazide (EEBAH) and 2-(2-propyl-1H-benzimidazol-1-yl) acethydrazide (EPBAH). The corrosion inhibition was investigated by weight loss, electrochemical impedance spectroscopy and potentiodynamic polarization studies. The adsorption interaction between metal and inhibitor followed Langmuir adsorption isotherm. The Gibb’s free energy values clarify the spontaneous nature of adsorption process. The temperature dependence of inhibition efficiency was explained by considering thermodynamic parameters of adsorption and kinetic parameters of corrosion. These inhibitors showed good efficiency at lower as well as moderately higher temperatures. Quantum chemical calculations were done using DFT at the B3LYP/6-31G¹ level to study the electronic properties of the molecules for correlating the inhibitive effect and molecular structure.     

Vitamin E and its anticancer effects

Abstract

Vitamin E is a lipid soluble vitamin comprising of eight natural isoforms, namely, α, β, δ, γ isoforms of tocopherol and α, β, δ, γ isoforms of tocotrienol. Many studies have been performed to elucidate its role in cancer. Until last decade, major focus was on alpha tocopherol and its anticancer effects. However, major clinical trials using alpha-tocopherol like SELECT trial and ATBC trial did not yield meaningful results. Hence there was a shift of focus to gamma-tocopherol, delta-tocopherol and tocotrienol. Unlike alpha-tocopherol, gamma-tocopherol and delta-tocopherol can scavenge reactive nitrogen species in addition to reactive oxygen species. Antiangiogenic effect, inhibition of HMG CoA reductase enzyme and inhibition of NF-κB pathway make the anti-cancer effects of tocotrienols unique compared to other vitamin E isoforms. Preclinical research on non-alpha tocopherol isoforms of vitamin E showed promising data on their anticancer effects. In this review, we deal with the current understanding on the potential mechanisms involved in the anticancer effects of vitamin E and the controversies in this field over last three decades. We also highlight the need to conduct further research on the anticancer effects of non-alpha-tocopherol isoforms in larger population and clinical setting.     

Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting,penetrating and nuclear accumulation

The authors regret that there was an error in our publication.Considering Lingchuang Bai made great contributions to this work,Xinghong Duo and Lingchuang Bai should be co-first authors,but there was no statement that“Xinghong Duo and Lingchuang Bai contributed equally to this work”.The authors would like to apologize for any inconvenience caused.