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11.
A Dick G Adam E Spüntrup A Prescher A Mühler RW Günther 《Canadian Metallurgical Quarterly》1996,165(4):392-397
PURPOSE: In an experimental pyogenic liver abscess model, the signal intensities were compared intraindividually and interindividually after the application of a new blood pool contrast agent, 24-gadolinium-DTPA (diethylenetriamine-pentaacetic acid) cascade polymer, and after the application of gadopentetate dimeglumine. METHODS: In 20 rabbits with experimentally induced liver abscesses, the relative signal intensities of the liver, abscess centre, abscess wall and portal vein were assessed before and between 30 seconds and 60 minutes after injection of a 25 mumol/kg dose of gadolinium polymer and of 100 mumol/kg of gadolinium-DTPA, respectively. Measurements were performed at 1.5 Tesla, using a head coil and a Flash-2-D sequence. RESULTS: The interindividual comparison (unpaired T-test, p < 0.05) yielded significant differences of the relative signal intensities of the abscess centre (at any time point after contrast-media application), abscess wall (between 15 and 60 minutes after contrast media application), and portal vein (between 30 seconds and 7.5 minutes after contrast media application). The interindividual comparison showed a significantly higher abscess centre-liver contrast (between 30 seconds and 12.5 minutes after contrast media application) and a significantly higher abscess wall-centre contrast (between two and 7.5 minutes after contrast media application) after the application of gadolinium polymer compared with gadopentetate dimeglumine. CONCLUSION: In this animal model, the higher abscess centre-liver contrast after the application of gadolinium polymer was the basis for a better and prolonged visibility of the abscesses, as compared with images acquired after injection of gadopentetate dimeglumine. 相似文献
12.
The brittle-ductile transition temperature in the solidification range depends on the composition of the phase which solidifies as the last one. The paper presents a thermochemical study of Fe-Mn-C-P system, determining the conditions of crystallisation of carbides, phosphides and the pseudo-ternary eutectic ML-M3C-M3P. Manganese raises the phosphorus concentration in eutectic. The eutectic temperature attains its maximum at about 6% of Mn. Then the brittle-ductile transition temperature is about 30 K higher than in ternary Fe-C-P alloy. A further raise is possible when the alloy is modified by an element forming stable, solide carbide, for ex. titanium. The results of theoretical analysis were verified by experimental work. The influence of titanium on the inclusions appearing in the vicinity of hot cracks of Hadfield cast steel has been studied. 相似文献
13.
14.
Virtual reality is for real 总被引:1,自引:0,他引:1
Some current applications work in the computer-rendered environments known as virtual reality (VR) are examined. Caterpillar Inc., a manufacturer of earth-moving and construction equipment is using VR to assess interior visibility on new prototypes. The Big Three among US automobile makers are joining with a US Army vehicle center, United Technologies' automotive division, the University of Michigan, and a dozen other smaller companies to form a consortium for industrial VR. Boeings' new airliner, the 777, to be rolled out next year, is its first to be designed without the use of a full-scale physical mockup; VR was used instead. Military, medical, and entertainment applications of VR are growing 相似文献
15.
S Massart D Maiter D Portetelle E Adam R Renaville JM Ketelslegers 《Canadian Metallurgical Quarterly》1993,139(3):383-393
Administration of GH complexed with monoclonal antibodies (MABs) potentiates the in vivo actions of the hormone. In particular, growth and serum IGF-I concentrations of GH-treated hypophysectomized rats are increased by concomitant injection of anti-GH MABs. Among 37 anti-bovine GH (bGH) MABs, we selected one MAB with the most potentiating effects to investigate the mechanisms responsible for this phenomenon. Hypophysectomized rats were killed 18 h after a single s.c. injection of bGH (100 micrograms/rat), alone or complexed with increasing doses of MAB (4, 40, 400 micrograms/rat; MAB:bGH molar ratio: 0.005, 0.05, 0.5). IGF-I was measured by radioimmunoassay in acid-extracted sera and livers, whereas liver IGF-I mRNA was quantified by Northern blot hybridization. The in vivo occupancy of liver somatogenic (GH) receptors was derived from the determinations of total and free 125I-labelled bGH binding to liver homogenates treated with 4 mol MgCl2/l or water. Injection of MAB-bGH complexes enhanced body weight gain and raised serum IGF-I, liver IGF-I and liver IGF-I mRNA more than bGH alone (1.6-, 6-, 10- and 7-fold increases at the highest dose of MAB, compared with bGH alone; P < 0.001). These potentiating effects of the MAB were dose-dependent and significant potentiation of the growth response was already observed with the lowest dose of MAB. In vivo occupancy of liver GH receptors was markedly higher 18 h after injection of MAB-bGH complexes than after bGH alone, and this effect was also dose-dependent (receptor occupancy of 28%, 37% and 83% after 4, 40 and 400 micrograms of MAB respectively compared with 6% after bGH alone; P < 0.05, 0.05 and 0.001 respectively). In contrast, the in vitro binding of 125I-labelled bGH to liver homogenates was decreased in the presence of high doses of MAB. We conclude that low amounts of MABs complexed with bGH potentiate the stimulation by the hormone of liver IGF-I synthesis and secretion in a dose-dependent manner. These effects are mediated, at least in part, through changes in hormone-receptor interaction in vivo, leading to enhanced and/or prolonged binding of bGH to its somatogenic receptors. 相似文献
16.
17.
Alter Adam L.; Oppenheimer Daniel M.; Epley Nicholas; Eyre Rebecca N. 《Canadian Metallurgical Quarterly》2007,136(4):569
Humans appear to reason using two processing styles: System 1 processes that are quick, intuitive, and effortless and System 2 processes that are slow, analytical, and deliberate that occasionally correct the output of System 1. Four experiments suggest that System 2 processes are activated by metacognitive experiences of difficulty or disfluency during the process of reasoning. Incidental experiences of difficulty or disfluency--receiving information in a degraded font (Experiments 1 and 4), in difficult-to-read lettering (Experiment 2), or while furrowing one's brow (Experiment 3)--reduced the impact of heuristics and defaults in judgment (Experiments 1 and 3), reduced reliance on peripheral cues in persuasion (Experiment 2), and improved syllogistic reasoning (Experiment 4). Metacognitive experiences of difficulty or disfluency appear to serve as an alarm that activates analytic forms of reasoning that assess and sometimes correct the output of more intuitive forms of reasoning. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
18.
P Majno D Castaing R Adam E Savier O Ghemard H Bismuth 《Canadian Metallurgical Quarterly》1998,52(6):518-526
Over the last few decades there has been a substantially higher percentage of successful organ transplants but also a significant imbalance between the demand for and the supply of organs, creating the basis for a highly profitable black market trade in human organs. Sometimes there are reports that children have been kidnapped, only to reappear later lacking one kidney, or that they simply disappear and are subsequently killed to have all their transplantable organs removed for profit. The European Union feels that there is a need for action and that it has a duty to act in this field, especially for ethical reasons. There is now established close co-operation between the various European transplant organizations. The legal protection of children with regard to organ transplantation is not specifically mentioned in the existing conventions because this issue was not foreseen at the time of their preparation. However, the issue is covered in a broader sense by more general provisions. There are endless rumours surrounding this area. Members of various organizations who travel in the suspected countries say that the trafficking in children who are sold for transplantation is well known, but it is too difficult and very dangerous to catch the people involved. We have to conclude that it has been impossible to prove or disprove the rumours, but they are consistent and we all, especially in the health care professions, have an obligation to be keenly aware of how and where organs are obtained. 相似文献
19.
Adam Prout Joanne M. Atlee Nancy A. Day Pourya Shaker 《Software and Systems Modeling》2012,11(2):251-272
We are investigating semantically configurable model-driven engineering (MDE). The goal of this work is a modelling environment that supports flexible, configurable modelling
notations, in which specifiers can configure the semantics of notations to suit their needs and yet still have access to the
types of analysis tools and code generators normally associated with MDE. In this paper, we describe semantically configurable code generation for a family of behavioural modelling notations. The family includes variants of statecharts, process algebras, Petri Nets,
and SDL88. The semantics of this family is defined using template semantics, which is a parameterized structured operational semantics in which parameters represent semantic variation points. A specific notation is derived
by instantiating the family’s template semantics with parameter values that specify semantic choices. We have developed a
code-generator generator (CGG) that creates a suitable Java code generator for a subset of derivable modelling notations.
Our prototype CGG supports 26 semantics parameters, 89 parameter values, and 7 composition operators. As a result, we are
able to produce code generators for a sizable family of modelling notations, though at present the performance of our generated
code is about an order of magnitude slower than that produced by commercial-grade generators. 相似文献
20.
J. D. Adam 《Circuits, Systems, and Signal Processing》1985,4(1-2):301-316
Conclusion Significant improvements are required in the performance of MSW dispersive delay lines and filter banks before they are ready for systems application. Typically delay lines with bandwidths of 1 GHz or greater, differential delays in the range 200 ns to 1s, and minimum phase errors (<±1 °) are required for large (40 dB) dynamic range compressive receivers. However, techniques are evolving (see rest of this issue) in this relatively new area of technology which will allow systems performance requirements on phase errors to be met. Possible approaches to low phase error dispersive delay lines include reflective arrays, stepped ground planes, and multiple YIG films. The stepped ground plane technique is the most advanced and uses an optimization approach to the delay-line design, which results in a minimum phase error [20]. Ultimately the minimum achievable phase error will be limited by reflections from transducers and multiple mode effects in the delay lines. The MSW compressive receiver requires parallel advances in high-speed digital processing techniques to achieve its full potential.The MSW filter bank provides a simple channelization technique applicable up to approximately 20 GHz. Narrowband channels with 10 dB insertion loss, 3 dB bandwidths of 10 to 40 MHz, and 50 dB bandwidths of 30 to 120 MHz are possible with the already demonstrated techniques. Broader bandwidth channels in the range 50 to 200 MHz with flat passband response require improved transducer design techniques. The channelized receiver does not require extremely high-speed operations but, since a large number of channels are involved, size and cost become very significant. 相似文献