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991.
992.
Susan A. Bernal John L. Provis David G. Brice Adam Kilcullen Peter Duxson Jannie S.J. van Deventer 《Cement and Concrete Research》2012,42(10):1317-1326
The carbonation resistance of alkali-activated binders is often tested via accelerated test protocols designed for Portland cements, without questioning whether the tests replicate the mechanisms observed in service. Thus, validation of accelerated methods is required to enable realistic prediction of material performance. Changes in pore solution equilibria cause the formation of sodium bicarbonates during accelerated carbonation, compared with hydrous sodium carbonates in natural carbonation. This shifts the carbonation mechanism to favour more rapid reaction progress, to give a higher apparent degree of acceleration (compared to natural conditions) than in Portland cements. The pore solution pH under accelerated carbonation is significantly lower than at natural CO2 concentrations, leading to a falsely short predicted service life (time to expected corrosion of embedded steel), as natural CO2 concentrations appear not to reduce the pH below 10. Thus, accelerated carbonation testing is unduly aggressive towards alkali-activated binders, and test results must be cautiously interpreted. 相似文献
993.
Adam Bartsch Edward Benzel Vincent Miele Douglas Morr Vikas Prakash 《Accident; analysis and prevention》2012
The Hybrid III 50th percentile male anthropomorphic test device (ATD) is the most widely used human impact testing surrogate and has historically been used in automotive or military testing. More recently, this ATD is finding use in applications evaluating athletic helmet protectivity, quantifying head impact dosage and estimating injury risk. But ATD head–neck response has not been quantified in omnidirectional athletic-type head impacts absent axial preload. It is probable that headgear injury reduction that can be quantified in a laboratory, including in American football, boxing, hockey, lacrosse and soccer, is related to a number of interrelated kinetic and kinematic factors, such as head center of gravity linear acceleration, head angular acceleration, head angular velocity, occipito-cervical mechanics and neck stiffness. Therefore, we characterized ATD head–neck dynamic response to direct head impacts in a series of front, oblique front and lateral head impacts. 相似文献
994.
Grand Roman Joldes Adam Wittek Karol Miller 《International journal for numerical methods in engineering》2012,91(4):450-456
Real‐time computational biomechanics for medicine usually uses explicit time integration, because of its efficiency and suitability for parallel implementation. Explicit time integration is only conditionally stable and therefore requires an estimation of the maximum stable time step that can be used. In this paper we develop a method of estimating the stable time step for mesh‐free particle methods for a specific case of mass lumping: the mass associated with an integration point is distributed equally to all nodes found in the support domain of that integration point. Two estimates of the stable time step for each integration point are developed: one that is very accurate but more costly to compute and one less accurate but easier to implement. The results are also valid for the FEM and beyond computational biomechanics for medicine. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
995.
996.
997.
Adam Bohr Jakob Kristensen Mark Dyas Mohan Edirisinghe Eleanor Stride 《Journal of the Royal Society Interface》2012,9(75):2437-2449
Poly(lactic-co-glycolic acid) (PLGA) microspheres containing celecoxib were prepared via electrospraying, and the influence of three processing parameters namely flow rate, solute concentration and drug loading, on the physico-chemical properties of the particles and the drug-release profile was studied. Microspheres with diameters between 2 and 8 μm were produced and a near-monodisperse size distribution was achieved (polydispersivity indices of 6–12%). Further, the inner structure of the particles showed that the internal porosity of the particles increased with increasing solvent concentration. X-ray powder diffraction (XRPD) analysis indicated that the drug was amorphous and remained stable after eight months of storage. Drug release was studied in USP 2 (United States Pharmacopeia Dissolution Apparatus 2) dissolution chambers, and differences in release profiles were observed depending on the parametric values. Changes in release rate were found to be directly related to the influence of the studied parameters on particle size and porosity. The results indicate that electrospraying is an attractive technique for producing drug-loaded microspheres that can be tailored towards an intended drug-delivery application. Compared with the more conventional spray-drying process, it provides better control of particle characteristics and less aggregation during particle formation. In particular, this study demonstrated its suitability for preparing capsules in which the drug is molecularly dispersed and released in a sustained manner to facilitate improved bioavailability. 相似文献
998.
Ozgur Sahin Ee Hou Yong Adam Driks L. Mahadevan 《Journal of the Royal Society Interface》2012,9(76):3156-3160
Bacillus spores are highly resistant dormant cells formed in response to starvation. The spore is surrounded by a structurally complex protein shell, the coat, which protects the genetic material. In spite of its dormancy, once nutrient is available (or an appropriate physical stimulus is provided) the spore is able to resume metabolic activity and return to vegetative growth, a process requiring the coat to be shed. Spores dynamically expand and contract in response to humidity, demanding that the coat be flexible. Despite the coat''s critical biological functions, essentially nothing is known about the design principles that allow the coat to be tough but also flexible and, when metabolic activity resumes, to be efficiently shed. Here, we investigated the hypothesis that these apparently incompatible characteristics derive from an adaptive mechanical response of the coat. We generated a mechanical model predicting the emergence and dynamics of the folding patterns uniformly seen in Bacillus spore coats. According to this model, spores carefully harness mechanical instabilities to fold into a wrinkled pattern during sporulation. Owing to the inherent nonlinearity in their formation, these wrinkles persist during dormancy and allow the spore to accommodate changes in volume without compromising structural and biochemical integrity. This characteristic of the spore and its coat may inspire design of adaptive materials. 相似文献
999.
Adam MacKenzieJ.O. Miller Raymond R. HillStephen P. Chambal 《Simulation Modelling Practice and Theory》2012,20(1):89-98
This research develops an agent based simulation model for application to the sortie generation process, focusing on a single fighter aircraft unit. The simulation includes representations of each individual maintainer within the unit, along with supervisory agents that provide direction in the form of dynamic task prioritization and resource assignment. Using a high-fidelity depiction of each entity, an exploration of the effects of different mixes of skill levels and United States Air Force Specialty Codes (AFSCs) on sortie production is performed. Analysis is conducted using an experimental design with results presented demonstrating the effects of maintenance manning decisions on the Combat Mission Readiness (CMR) of a fighter unit. 相似文献
1000.
Craver-Lemley Catherine; Arterberry Martha E.; Reeves Adam 《Canadian Metallurgical Quarterly》1999,25(4):1036
The question of whether illusory conjunctions would occur with visual mental imagery was investigated. In 4 experiments, participants were tachistoscopically presented displays of geometrical figures (varying in shape, color, and solidity) flanked by 2 digits. For half of the trials, participants imagined one of the figures in the display. Illusory conjunctions occurred between the features of the physical (cued) and imagined figures, which suggests that imagery influences perception at the level of visual processing at which features are combined. Moreover, the conjunction errors induced by an imagined figure were similar to those induced by a physical figure with the same features. The pattern of errors could not be accounted for by guessing. Together, these findings support the view that there can be correspondence between visual imagery and visual perception. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献