Tiapride-induced catalepsy is potentiated by gamma-hydroxybutyric acid administration

A young man is presented who developed an akinetic-rigid syndrome shortly after a minor illness. Rituals and stereoptypies were prominent. At its most severe he was unable to feed himself. There was no response to L-dopa/cardopa treatment. A course of ECT was followed by a marked improvement in his condition. Attempts to stop ECT for more than a week have led to recurrence of his bradykinesia.     

A high-speed digital correlator for radio astronomy

Design details for a high-speed digital cross correlator for the Owens Valley Millimeter Array are presented. The correlator uses ECL gate arrays operating at a 256-MHz clock rate to compute the real cross-correlation function for up to four independent frequency bands with bandwidths in the range of 2-128 MHz. For each baseline in the array the correlator provides 512 lags, giving a spectral resolution of 2 MHz at the maximum bandwidth. Two-bit digitization is used, and this results in a sensitivity of 0.88 relative to a perfect analog correlator     

New interactive verbal dichotic listening test

INTRODUCTION AND OBJECTIVE: From the multimedia technology and of the digital recording of the voice, we have redesigned the verbal dichotic listening test. The recognition of 15 monosyllabic word pairs offered though some earphones is presented in an interactive program. METHODS: Using the mouse button, the subject decides the moment in which each stimuli coupe will take place. Likewise, the screen displays 10 words, among which you have to recognize the words supplied by the earphones. Finally, the program results in complete right answers and right answers cross or referred to the opposite ear. RESULTS: Applied the test to a sample of 92 subjects, apparently normal, with a middle and high cultural level, from among 19 and 60 years (44 females and 48 males), the test resulted in a predominance of rights answers in the right ear (p < 0.0064). Separated the sample in in left-handed and right-handed men (67 right handed and 25 left-handed), it hasn't been found meaningful differences among their averages. Separated the sample by sex, the differences among the slightly meaningful averages (p < 0.04, according to the Student's t test). CONCLUSIONS: The test is offered as a resource appropriate for laterality studies, and for differential disorder study of gnosias and praxias of the dyslexias of aphasias, hearing aids, multiple sclerosis, and aptitudes studies.     

Anthocyanin composition of Tempranillo, Garnacha and Cabernet Sauvignon grapes from high- and low-quality vineyards over two years

The anthocyanin composition of Tempranillo, Garnacha and Cabernet Sauvignon grapes over two vintages was studied. Samples were obtained during berry ripening from two vineyards that differed by producing fruit of high and low quality. The proportions of the individual compounds remained practically constant within a single vineyard along the sampling period, the changes in the anthocyanin composition being principally quantitative. Different multivariate statistical methods showed that the anthocyanin profile was primarily determined by variety. This genetic dependence was particularly verified when the sums of the non-acylated glucosides, the acetates and the p-coumaryl derivatives, were analysed. The mean relative content corresponding to these three anthocyanin fractions was always the same within each variety, independently either of the vineyard or the vintage year considered. Relating to the individual compounds, several permanent qualitative differences between vineyards in each variety were also found, although the difference in the total anthocyanin concentration was always much higher.     

Chimerism analysis in long-term survivor patients after bone marrow transplantation for severe aplastic anemia

BACKGROUND AND OBJECTIVE: Allogeneic bone marrow transplantation (BMT) is the most common treatment for young patients with severe aplastic anemia (SAA). Late graft failure represents one of the possible unfavorable outcomes in this setting. Mixed chimerism might represent a risk factor for late graft failure. We examined this relationship by studying chimerism in long-term survivor SAA patients after allogeneic BMT. METHODS: We analyzed long-term hematopoietic chimerism in 15 patients who received BMTs for SAA: 9 with an irradiation-based conditioning regimen and 6 with ATG. We used a PCR method targeting VNTR loci. Sensitivity of the technique ranged between 0.5 and 1.5%. RESULTS: All patients conditioned with radiation-based schemes showed complete donor chimerism. Conversely, out of six patients who received cyclophosphamide and ATG as a conditioning regimen, only one of them had late graft failure (day +168). In this patient, durable mixed chimera status was first detected two months after BMT. INTERPRETATION AND CONCLUSIONS: Our results suggest that in long-term survivors of SAA after BMT there is almost always complete donor chimerism in both irradiated and ATG-conditioned recipients. Mixed chimerism might predict graft failure in these patients.     

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Parkinson's disease

We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 34 patients with Parkinson's disease (PD) and 47 controls. CSF and serum vitamin E levels were correlate. The mean CSF and serum vitamin E levels, and the CSF/serum ratio of PD patients did not differ significantly between the groups. There was no influence of antiparkinsonian therapy on CSF vitamin E levels. CSF vitamin E levels did not correlate with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. These results suggest that CSF vitamin E concentrations are unrelated with the risk for PD.     

Multiplexer model for RTL satisfiability using MILP

New approaches to the satisfiability problem (SAT) for register transfer level (RTL) designs combine arithmetic blocks with Boolean logic to form a mixed integer linear program (MILP). Two-to-one multiplexers with word-level inputs can be decomposed to logic gates, but it is more efficient to describe them in MILP constraints as arithmetic operators. Larger multiplexers are built using a multilevel selection tree. However, such an approach should be improved to optimise the overall efficiency in solving the SAT problem. Proposed is a new MILP model for multiplexers. Experimental results indicate a 50% decrease in the number of constraints and a reduction in MILP complexity from /spl Omega/(N/sup 2.4/) to /spl Omega/(N/sup 1.7/), measured in CPU time.     

Heart rate changes during the Valsalva maneuver in patients with isolated aortic insufficiency

To determine the possible relationship between left ventricular dilatation and heart rate changes provoked by the Valsalva maneuver (Valsalva ratio), we studied 9 patients with isolated chronic aortic insufficiency. Left ventricular systolic function was assessed by two-dimensional echocardiography and cardiac catheterization. All patients were asymptomatic (functional class I of the New York Heart Association). The left ventricular internal diameters and volumes were significantly increased in all patients. The asymptomatic patients had either normal or slightly depressed ejection fraction (EF > 0.40). The Valsalva ratio of these asymptomatic patients showed no significant correlation with the left ventricular volumes or with the left ventricular ejection fraction. In other words, parasympathetic heart rate control, as expressed by the Valsalva ratio, was normal in the asymptomatic patients with left ventricular dilatation and preserved left ventricular ejection fraction. Therefore, left ventricular dilatation may not be the major mechanism responsible for the abnormal parasympathetic heart rate control of patients with acquired heart disease.     

Cytotoxic isoflavans from Eysenhardtia polystachya

Two new cytotoxic isoflavans, (3S)-7-hydroxy-2',3',4',5', 8-pentamethoxyisoflavan (1) and (3S)-3',7-dihydroxy-2',4',5', 8-tetramethoxyisoflavan (2), were isolated from the bark and trunks of Eysenhardtia polystachya (Leguminosae), together with the known constituents stigmasterol, isoduartin, cuneatin, 7-hydroxy-2',4', 5'-trimethoxyisoflavone, and 3,4-dimethoxy-8, 9-(methylenedioxy)pterocarpan. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods. The antimicrobial, cytotoxic, and insecticidal potential of some of these compounds were evaluated. The isoflavans 1, 2, and isoduartin (2', 7-dihydroxy-3',4',8-trimethoxyisoflavan) displayed moderate cytotoxic activity against KB cell lines.     

Status of insecticide resistance in 4 strains of Musca domestica collected in animal farms

This paper describes patterns of infection with Tunga penetrans within the town of Icacos, Trinidad, West Indies, assessed by the number of persons infected and the extent of the chigoe flea burden by physical examination. The overall prevalence of infection was 31.4% (102 infected persons) of the 325 persons examined (41% of males and 23% of females). Both measures showed a significant difference among the different age groups with peak chigoe burden found in the 5-9, 10-14 and > 55 age-groups, with 9, 5.6 and 12 fleas per infected person, respectively. The aggregated distribution of chigoe flea burden showed a few persons with many fleas and many persons with none (68%). In contrast, in chigoe flea burden there were no significant sex differences but age-associated differences (G = 17.9; d.f. 7; P < 0.01). It is recommended that all cases of tungiasis should be treated and the source of infection effectively managed or eradicated.