Short term protective effect of digitoxin in sepsis-induced acute lung injury

Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known anti-inflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group. Conclusion: Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action, and healing effects in both computerized tomography and histology in the lung.     

TestAnt: An ant colony system approach to sequential testing under precedence constraints

We consider the problem of minimum cost sequential testing (diagnosis) of a series (or parallel) system under precedence constraints. We model the problem as a nonlinear integer program. We develop and implement an ant colony algorithm for the problem. We demonstrate the performance of this algorithm for special type of instances for which the optimal solutions can be found in polynomial time. In addition, we compare the performance of the ant colony algorithm with a branch and bound algorithm for randomly generated general instances of the problem. The ant colony algorithm is particularly effective as the problem size gets larger.     

A receding contact problem between a functionally graded layer and two homogeneous quarter planes

In this paper, the plane problem of a frictionless receding contact between an elastic functionally graded layer and two homogeneous quarter planes is considered when the graded layer is pressed against the quarter planes. The top of the layer is subjected to normal tractions over a finite segment. The graded layer is modeled as a non-homogeneous medium with a constant Poisson’s ratio and exponentially varying shear modules. The problem is converted into the solution of a Cauchy-type singular integral equation in which the contact pressure and the receding contact half-length are the unknowns using integral transforms. The singular integral equation is solved numerically using Gauss–Jacobi integration. The corresponding receding contact half-length that satisfies the global equilibrium condition is obtained using an iterative procedure. The effect of the material non-homogeneity parameter on the contact pressure and on the length of the receding contact is investigated.     

URBAN PROBLEM DISCOURSES: UNDERSTANDING THE DISTINCTIVENESS OF CITIES

Despite the insistence in interpretive policy analysis that the discursive construction of problems must be understood in terms of their historical and spatial context, it remains an open question how cities provide such a context. We argue that cities as a distinct form of sociation enable certain (discursive) actions, while restricting others. Taking both the interest of interpretive policy analysis in the social construction of political reality and holistic concepts of approaching the distinctiveness of cities as starting points, we scrutinize how the cities of Frankfurt/Main, Dortmund, Birmingham, and Glasgow provide distinct contexts for the construction of local policy problems. Based on an inquiry into urban discourses we ask, first, how problematizations involve locally specific attributions of problem causes and responsibilities for problem solving and, second, how this is related to a locally distinct understanding of the city's past, present, and future.