DNA‐Scaffolded Multivalent Ligands to Modulate Cell Function

We report a simple, versatile, multivalent ligand system that is capable of specifically and efficiently modulating cell‐surface receptor clustering and function. The multivalent ligand is made of a polymeric DNA scaffold decorated with biorecognition ligands (i.e., antibodies) to interrogate and modulate cell receptor signaling and function. Using CD20 clustering‐mediated apoptosis in B‐cell cancer cells as a model system, we demonstrated that our multivalent ligand is significantly more effective at inducing apoptosis of target cancer cells than its monovalent counterpart. This multivalent DNA material approach represents a new chemical biology tool to interrogate cell receptor signaling and functions and to potentially manipulate such functions for the development of therapeutics.     

基于新型联想记忆系统的机器人分布式智能控制

基于离散泰勒级数提出一种对多维函数可实现任意阶逼近的新型CMAC神经网络——DTS-CMAC，详细讨论了该系统的插值算法、训练规则，与传统CMAC相比，DTS-CMAC具有学习精度高、学习速度快及占用存储单元少等优点。基于DTS-CMAC设计了一种高性能的机械手轨迹跟踪分布式智能控制方案，并以肘关节为例，设计了机械手关节转矩控制器，仿真研究表明了该方案的可行性与有效性。     

A systematic approach to preliminary polymer process development: modeling and design

A general and complete methodology is presented to facilitate systematic modeling and design of polymer processes during the early development period. To capture and handle the subjective type of uncertainty, embedded in the preliminary process development, fuzzy theories are used as a basis to model and design the process in the presence of ambiguity and vagueness. Physical membership functions are developed for mapping the relation between process variables and the associated fuzzy uncertainties. Based on the qualitative results generated using our previously proposed “linguistic based preliminary design method,” the process modeling can be followed even in the absence of any process governing equations. The modeling is carried out by establishing an appropriate fuzzy reasoning system which provides a specific functional mapping that relates input process variables to one (or more than one) output performance parameter(s). A reduced yet feasible domain is generated by our qualitative design scheme to constrain the process variables. Now, any optimization routine can then be employed to search for a proper process design. We demonstrate the effectiveness of the proposed methodology by its application to a typical compression molding process.     

GPRS无线数据传送在远程采集系统中的应用

利用GPRS模块Q2406B和单片机W77E58，实现了在远程采集系统中应用GPRS无线传送数据。经试验证明，谊系统：运行良好，传输数据稳定。     

Qualitative and quantitative identification of adulteration of milk powder using DNA extracted with a novel method

The extraction of high-quality DNA from processed dairy products is often the crucial step in an authentication process by PCR-based methods. In this study, we optimized a novel DNA extraction method for milk powder and used the extracted DNA for identification of milk powder based on PCR analysis. The DNA quality was assessed by amplifying target sequences from mitochondrial genes, as well as by monitoring the yield, purity, and integrity of the extracted DNA. In addition, a laboratory adulteration model of milk powder was detected by PCR-based methods (PCR and real-time PCR) using primers targeting the mitochondrial 12S rRNA gene. Results showed that a sufficient amount and quality of DNA could be isolated from milk powder with this method. Both PCR and real-time PCR detection of cow milk compositions in goat milk powder further confirmed the DNA extracted with this extraction method could be widely used in addressing milk powder adulterant by a PCR-based method.     

Phase characterisation of metalenses

Metalenses have emerged as a new optical element or system in recent years, showing superior performance and abundant applications. However, the phase distribut...     

以电子设计竞赛推动《EDA技术》课程教学改革

《EDA技术》作为电子信息类专业方向一门重要的专业基础课程,对培养大学生的创新实践能力具有重要的作用。分析了当前《EDA技术》课程的现状以及存在的教学弊端,提出以电子设计竞赛理念为主导,在教学理念、教学方法以及考核方法等方面提出了具体的改革措施。经过课堂教学实践证明,改革方法对于提高大学生学习的主动性和创造性,以及增强实践动手能力具有良好作用,对于提高电子设计竞赛的成绩具有明显的效果。     

H @ -Robustness properties preservation in SISO systems when applying SPR substitutions

The preservation of both robust stability and weighted robust performance properties of controlled linear time-invariant single input single output (SISO) systems is studied, when performing substitutions (of the complex Laplace variable s ) by a particular class of rational strictly positive real functions ( SPR functions), the so-called strictly positive real functions of zero relative degree ( SPR0 functions). Concerning weighted robust performance and model-matching, we provide some results on preservation of controller optimality.     

Synthesis, Crystal Structure, Spectroscopic and Thermal Investigations of a Novel 2D Sodium(I) Coordination Polymer Based on 2-Aminoterephthalic Ligand

The reaction of sodium hydroxide with 2-aminoterephthalic acid leads to the formation of a complex of the general formula: [Na₂(atpt)(H₂O)₅]·H₂O, where atpt?=?[NH₂C₆H₃(COO)₂]^2?. Sodium 2-aminoterephthalate was synthesized and characterized by single-crystal X-ray diffraction, FT-IR spectroscopy, thermal analysis and coupled TG–FT-IR technique. Crystallographic study of the sodium complex reveals that the compound crystallizes in the triclinic system, the space group P-1 with a?=?7.983(3) ?, b?=?8.405(3) ?, c?=?11.311(5) ?, α?=?70.74(3)°, β?=?76.57(3)°, γ?=?83.12(3)° and V?=?696.1(5) ?³. On heating in air atmosphere the compound in question loses all water molecules in two steps in the temperature range 30–205?°C. The anhydrous form of the complex is stable up to 370?°C and then decomposes to sodium carbonate.