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71.
R Kumar M Mandal A Lipton H Harvey CB Thompson 《Canadian Metallurgical Quarterly》1996,2(7):1215-1219
Overexpression of HER2 in estrogen receptor (ER)-positive human breast tumors has been associated with resistance to endocrine therapy. Here we investigated the effects of HER2 on expression of apoptotic pathways and modulation of tamoxifen-induced apoptosis in ER-positive MCF-7 breast cancer cells. We report that HER2 overexpression in MCF-7 cells is accompanied by up-regulation of antiapoptotic Bcl-2 and Bcl-XL proteins and suppression of tamoxifen-induced apoptosis. In addition, human tumor cell lines that are both ER positive and overexpress HER2 also express enhanced levels of Bcl-2 compared to cells that are either ER positive or overexpress HER2 alone. Our findings suggest that possible deregulation of antiapoptotic Bcl-2 and Bcl-XL may be associated with the enhanced survival of HER2-overexpressing and ER-positive breast cancer cells treated with antiestrogens. 相似文献
72.
A two-stage MMSE multiuser decision feedback detector using successive/parallel interference cancellation 总被引:1,自引:0,他引:1
In this paper, we present a novel two-stage minimum-mean-squared-error (MMSE) multiuser decision feedback detector (DFD) for code division multiple access systems working in the frequency-selective multipath fading environment. The first stage of the proposed cascaded structure is the noise-predictive successive DFD (NP-S-DFD), in which the active users are detected successively using the conventional bell labs layered space-time (BLAST) ordering criterion. The second stage includes an adaptive successive/parallel DFD (SP-DFD), which uses the tentative decisions obtained at the first stage for multiuser interference cancellation and data detection. Therefore, the proposed two-stage DFD may be called noise-predictive successive SP-DFD (NP-S-SP-DFD). Simulation results are presented to demonstrate the substantial improvement in the bit error rate performance of NP-S-SP-DFD over the conventional single-stage and cascaded DFDs. It may be inferred that the proposed DFD provides additional performance gain, when the order in which the users are detected is optimized according to the BLAST ordering based on MMSE criterion. 相似文献
73.
T. Luo C. Yu L.-S. Yan S. Kumar Z. Pan A.E. Willner 《Photonics Technology Letters, IEEE》2006,18(15):1606-1608
We demonstrate a simple optical-fiber-based autocorrelator for picosecond short pulses based on degree-of-polarization measurement while tuning the relative delay of the two orthogonal polarization states of the pulse. The pulsewidths of 20-, 40-, and 80-GHz pulse trains and 2-ps pulses generated by a mode-locked laser are measured. The <-10-dBm optical powers are used in the experiment. The measurement results agree well with the measurements using conventional techniques. Compared with conventional autocorrelators, this technique has the advantages of 1) wavelength independent, 2) significant less alignment, and 3) no high power required. 相似文献
74.
Buffer overflow vulnerabilities are one of the most commonly and widely exploited security vulnerabilities in programs. Most existing solutions for avoiding buffer overflows are either inadequate, inefficient or incompatible with existing code. In this paper, we present a novel approach for transparent and efficient runtime protection against buffer overflows. The approach is implemented by two tools: Type Information Extractor and Depositor (TIED) and LibsafePlus. TIED is first used on a binary executable or shared library file to extract type information from the debugging information inserted in the file by the compiler and reinsert it in the file as a data structure available at runtime. LibsafePlus is a shared library that is preloaded when the program is run. LibsafePlus intercepts unsafe C library calls such as strcpy and uses the type information made available by TIED at runtime to determine whether it would be ‘safe’ to carry out the operation. With our simple design we are able to protect most applications with a performance overhead of less than 10%. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
75.
76.
Because of the rapid changes in saturation which take place in the immediate vicinity of a displacement front, it is not possible to estimate relative permeabilities over the entire saturation range of interest when using the external-drive method. It is demonstrated in this study that this limitation can be removed, if data from an unstabilized and/ or unstable displacement are used. Furthermore, it is shown that use of such data is permissible, provided: (a) saturation profiles and pressure gradients in both phases can be measured directly; (b) the external-drive theory is modified to account for the existence of capillary pressure gradients; and (c) the analysis is carried out from a Lagrangian rather than a Eulerian point of view.A comparison of relative permeabilities obtained by using the Lagrangian method with those obtained using the conventional (without capillary pressure term) and the modified (with the capillary pressure term) Eulerian methods was undertaken to demonstrate the effect of the neglect of the capillary pressure term on relative permeabilities. Also investigated in this study was the impact of instability on the relative permeability and capillary pressure curves for unstable displacements and the effect of instability on the saturation profiles, fractional flow curves and the residual oil saturation. In addition, the effect of instability on the residual oil saturation was studied. 相似文献
77.
Layne T. Watson Kishore Kumar Sankara Luegina C. Mounfield 《International Journal of Engineering Science》1985,23(1):131-137
The flow due to a rotating disk decelerating with an angular velocity inversely proportional to time with either surface suction (or injection) which again varies with time is investigated. The unsteady Navier-Stokes equations are transformed to non-linear ordinary differential equations using similarity transformations. The resulting equations are solved numerically using a globally convergent homotopy method. The flow depends on two non-dimensional parameters, namely an unsteadiness parameter and a suction (or injection) parameter . Some interesting numerical results are presented graphically and discussed. 相似文献
78.
R K Mandal Ch. Durga Prasad O M Parkash Devendra Kumar 《Bulletin of Materials Science》1987,9(4):255-262
Glasses with varying molar ratios of PbO/BaO in the system BaO-PbO-TiO2-B2O3-SiO2 were prepared keeping (BaO + PbO)/TiO2 ratio equal to one. The glasses were ceramized by two-stage heat treatment. X-ray diffraction indicates that PbTiO3 crystallizes in lead-rich glasses while BaTiO3 precipitates in barium-rich compositions. Solid solution (Ba, Pb)TiO3 does not seem to crystallize over the entire range of compositions. Simultaneous presence of PbO and BaO in the initial glass
composition reduces the yield of ferroelectric phase. Dielectric properties have been interpreted in terms of microstructural
features. 相似文献
79.
AG Heriot D Kumar V Thomas M Young J Pilcher AE Joseph 《Canadian Metallurgical Quarterly》1998,85(12):1713-1715
BACKGROUND: The use of fine-needle aspiration cytology (FNAC) in the diagnosis of colonic lesions was investigated. METHODS: Some 22 patients (median age 71 years) with a colonic lesion identified on abdominal ultrasonography underwent ultrasonographically-guided FNAC using a 21-G needle. The sample was checked immediately by a cytopathologist for adequacy. RESULTS: Eighteen patients had colonic carcinoma; aspiration cytology detected malignant epithelial cells consistent with colonic carcinoma in 17 patients and severely dysplastic cells in one patient. The sensitivity and specificity of ultrasonographically-guided FNAC in the diagnosis of colonic carcinoma was 94 and 100 per cent respectively. The remaining four patients had a diagnosis of ileocaecal tuberculosis, ileocaecal Crohn's disease, and metastatic adenocarcinoma in the liver with no identifiable primary (two patients). One demonstrated granulomata, grew acid-fast bacilli and the patient was treated for tuberculosis. One had inflammatory cells and the patient was found to have Crohn's disease on histology. The remaining two patients had confirmed metastatic adenocarcinoma in the liver on aspiration cytology but suspected colonic lesions were found to be benign on cytological examination and no primary lesion was subsequently demonstrated. There were no complications of FNAC and patients complained of minimal discomfort. There has been no evidence of tumour recurrence with a median follow-up of 12 (range 1-25) months. CONCLUSION: Ultrasonographically-guided FNAC is a valid method for the diagnosis of colonic tumours. 相似文献
80.
Understanding the sequence-structure relationships in globular proteins is important for reliable protein structure prediction and de novo design. Using a database of 1131 alpha-helices with nonidentical sequences from 205 nonhomologous globular protein chains, we have analyzed structural and sequence characteristics of alpha-helices. We find that geometries of more than 99% of all the alpha-helices can be simply characterised as being linear, curved, or kinked. Only a small number of alpha-helices ( approximately 4%) show sharp localized bends in their middle regions, and thus are classified as kinked. Approximately three-fourths (approximately 73%) of the alpha-helices in globular proteins show varying degrees of smooth curvature, with a mean radius of curvature of 65 +/- 33 A; longer helices are less curved. Computation of helix accessibility to the solvent indicates that nearly two-thirds of the helices ( approximately 66%) are largely buried in the protein core, and the length and geometry of the helices are not correlated with their location in the protein globule. However, the amino acid compositions and propensities of individual amino acids to occur in alpha-helices vary with their location in the protein globule, their geometries, and their lengths. In particular, Gln, Glu, Lys, and Arg are found more often in helices near the surface of globular proteins. Interestingly, kinks often seem to occur in regions where amino acids with low helix propensities (e.g., beta-branched and aromatic residues) cluster together, in addition to those associated with the occurrence of proline residues. Hence the propensities of individual amino acids to occur in a given secondary structure depend not only on conformation but also on its length, geometry, and location in the protein globule. 相似文献