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51.
Masaaki Haneda Ohki Houshito Hiromitsu Takagi Kiyoshi Shinoda Yuunosuke Nakahara Kazumi Hiroe Tadahiro Fujitani Hideaki Hamada 《Topics in Catalysis》2009,52(13-20):1868-1872
The activity of Rh/CeO2 for NO reduction by C3H6 was gradually deceased by mixing with ZrO2 until 68 mol%. Rh supported on CeO2–ZrO2 with higher OSC was found to show lower catalytic activity. High OSC of CeO2–ZrO2 would probably stabilize the surface of Rh in oxidized state, resulting in low activity and low efficiency of C3H6 utilization for NO reduction. In situ FT-IR spectroscopy suggested that mononitrosyl species such as Rh(NO)δ? and Rh(NO)δ+ are reaction intermediates in the NO–C3H6–O2 reaction over Rh/CeO2–ZrO2 catalysts. 相似文献
52.
Kazuhiro Nagao Akira Koshino Akane Sugimura-Nagata Aya Nagano Masayuki Komura Akane Ueki Masahide Ebi Naotaka Ogasawara Toyonori Tsuzuki Kenji Kasai Satoru Takahashi Kunio Kasugai Shingo Inaguma 《International journal of molecular sciences》2022,23(6)
p53 immunohistochemistry is considered an accurate surrogate marker reflecting the underlying TP53 mutation status and has utility in tumor diagnostics. In the present study, 269 primary CRCs were immunohistochemically evaluated for p53 expression to assess its utility in diagnostic pathology and prognostication. p53 expression was wild-type in 59 cases (23%), overexpressed in 143 cases (55%), completely lost in 50 cases (19%), and cytoplasmic in 10 cases (4%). p53 immunoreactivity was associated with tumor size (p = 0.0056), mucus production (p = 0.0015), and mismatch repair (MMR) system status (p < 0.0001). Furthermore, among CRCs with wild-type p53 expression, a significantly higher number of cases had decreased CDX2 than those with p53 overexpression (p = 0.012) or complete p53 loss (p = 0.043). In contrast, among CRCs with p53 overexpression, there were significantly fewer ALCAM-positive cases than p53 wild-type cases (p = 0.0045). However, no significant association was detected between p53 immunoreactivity and the “stem-like” immunophenotype defined by CDX2 downregulation and ALCAM-positivity. Multivariate Cox hazards regression analysis identified tubular-forming histology (hazard ratio [HR] = 0.17, p < 0.0001), younger age (HR = 0.52, p = 0.021), and female sex (HR = 0.55, p = 0.046) as potential favorable factors. The analysis also revealed complete p53 loss (HR = 2.16, p = 0.0087), incomplete resection (HR = 2.65, p = 0.0068), and peritoneal metastasis (HR = 5.32, p < 0.0001) as potential independent risk factors for patients with CRC. The sub-cohort survival analyses classified according to chemotherapy after surgery revealed that CRC patients with wild-type p53 expression tended to have better survival than those with overexpression or complete loss after chemotherapy. Thus, immunohistochemistry for p53 could be used for the prognostication and chemotherapy target selection of patients with CRC. 相似文献
53.
The soft texture of the pizza crust rim is generated by baking at a high temperature for a short period in a stone oven. In the case of baking in an electric oven, the pizza dough is baked at a much lower temperature and for a longer period, resulting in a harder texture. To improve the texture of electric oven-baked pizza crust, the effects of water and gelatinized starch on the viscoelasticity of pizza dough and the texture of pizza crust were investigated. Rheological properties (storage modulus, loss modulus, and yield stress) of pizza dough decreased with an increase in water content. When wheat flour in the dough was partially replaced with pre-gelatinized wheat starch, the rheological properties of the dough were maintained even at a high-water content. These results indicate that water-enriched dough can be prepared with gelatinized starch and baked using an electric oven. There was no significant difference in apparent density between the conventional and modified pizza crusts. Water content of the crumb part of the modified crust was significantly higher than that of the conventional crust. Texture analysis revealed that the modified pizza crust showed significantly lower stress at high strain than the conventional crust. In addition, sensory evaluation showed that the modified pizza crust exhibited greater firmness and stickiness than the conventional crust, which was attributed to the increased water content with gelatinized starch of the dough. 相似文献
54.
Christina A. Hamada Michael S. Hamada 《Quality and Reliability Engineering International》2010,26(1):75-81
We consider an all‐subsets regression method for models under effect heredity restrictions for experimental designs with complex aliasing, whose number of potential main effects and two‐factor interactions exceed the number of runs. In this paper, we present an algorithm that systematically attempts to fit all such models. We illustrate the algorithm with two published experiments. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
55.
Akane Yamamichi Fumiharu Ohka Hiromichi Suzuki Akira Kato Kazuya Motomura 《Science and Technology of Advanced Materials》2016,17(1):618-625
World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69–80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (IDH1), of which 83–90% are found to be the IDH1-R132H mutation. Detection of the IDH1-R132H mutation should help in the differential diagnosis of grade II and III gliomas from other types of CNS tumors and help determine the boundary between the tumor and normal brain tissue. In this study, we established a highly sensitive antibody-based device, referred to as the immuno-wall, to detect the IDH1-R132H mutation in gliomas. The immuno-wall causes an immunoreaction in microchannels fabricated using a photo-polymerizing polymer. This microdevice enables the analysis of the IDH1 status with a small sample within 15 min with substantially high sensitivity. Our results suggested that 10% content of the IDH1-R132H mutation in a sample of 0.33 μl volume, with 500 ng protein, or from 500 cells is theoretically sufficient for the analysis. The immuno-wall device will enable the rapid and highly sensitive detection of the IDH1-R132H mutation in routine clinical practice. 相似文献
56.
We have investigated fluid flow characteristics of film‐wise condensation on vertical plates with horizontal periodic grooves. Condensate stays at the edge of the grooves due to the surface tension. The condensate starts to flow, however, when the balance between the surface tension and the condensate's own weight is broken. It is found that the condensate flows downward successively and periodically from the top part of the plate as a group. In addition, we have obtained the relation between the frequencies of the periodic flow and the degree of sub‐cooling for two different pitches of the grooves. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/htj.20249 相似文献
57.
Zhi-xue Tian Akifumi Uozumi Ikutaro Hamada Susumu Yanagisawa Hidetoshi Kizaki Kouji Inagaki Yoshitada Morikawa 《Nanoscale research letters》2013,8(1):203
First-principles calculations were performed to investigate the effect of Pd concentration and oxygen vacancies on the stability of Pd at LaFeO3 surfaces. We found a much stronger tendency of Pd to segregate by taking the aggregation of Pd at LaFe1-xPdxO3-y surfaces into consideration, resulting in a pair of Pd-Pd around a vacancy. Moreover, we predicted that one oxygen-vacancy-containing FeO2-terminated surfaces would be stable at high temperatures by comparing the stability of LaFe1-xPdxO3-y surfaces, which further supports our previous conclusion that a Pd-containing perovskite catalyst should be calcined at 1,073 K or higher temperatures in air to enhance the segregation of Pd in the vicinity of surfaces to rapidly transform the Pd catalyst from oxidized to reduced states on the perovskite support. 相似文献
58.
Hiroshi Kamimura Tsuyoshi Hamada Shun-ichi Matsuno Hideki Ushio 《Journal of Superconductivity》2002,15(5):379-385
The present novel approach consists of two stages: in the first stage the many-electron states of a CuO6 octahedron or a CuO5 pyramid are calculated by the first-principles variational method, by taking into account the local distortions of a CuO6 octahedron or a CuO5 pyramid. In the second stage a metallic state is constructed in the presence of the local AF ordering constructed by the localized spins. In this metallic state the local distortions are treated in the mean field approximation, so that a pseudopolaronic effect is taken into account. Based on this approach, the hole-concentration dependence of T
c and the isotope effect are calculated for LSCO, and compared with experimental results. This approach leads to d-wave pairing mechanism. 相似文献
59.
T Nishida TP Huang A Seiyama E Hamada W Kamiike S Ueshima H Kazuo H Matsuda 《Canadian Metallurgical Quarterly》1998,115(2):412-420
BACKGROUND & AIMS: Endothelin 1 is considered to be an important regulator of sinusoidal blood flow and increases during endotoxemia. The purpose of this study was to investigate the role of endothelin 1 in hepatic microcirculation, oxygen transport, and liver injury during endotoxemia. METHODS: Male Sprague-Dawley rats were continuously infused with 2.5 mL/h of saline, 0.8 mg . kg-1 . h-1 of lipopolysaccharide (LPS), 3 mg . kg-1 . h-1 of BQ-485, an endothelin A-receptor antagonist, or LPS plus BQ-485 for 7 hours. RESULTS: BQ-485 infusion had no significant effect on hepatic microcirculation and liver injury. LPS increased the plasma levels of aspartate aminotransferase (AST) and total bilirubin and decreased the hepatic adenosine triphosphate (ATP) level and bile flow rate. LPS + BQ-485 infusion further increased the plasma levels of AST and total bilirubin and decreased the bile flow rate and the hepatic ATP level. Dual-spot microspectroscopy revealed mild decreases in sinusoidal erythrocyte velocity and oxygen transport in the LPS group and profound decreases in these parameters in the LPS + BQ-485 group. Histological examinations revealed massive necrotic changes in the pericentral regions of the LPS + BQ-485 group. CONCLUSIONS: These results suggest that blockade of endothelin A receptors disturbs hepatic microcirculation and oxygen transport and aggravates the necrotic injury induced by endotoxin. 相似文献
60.
K Ueda M Konishi K Maeda K Hamada M Sakamoto E Yoshimoto T Majima K Mikasa E Kita R Sano T Masutani N Narita 《Canadian Metallurgical Quarterly》1998,72(12):1325-1329
A 78-year-old female was admitted with complaints of malaise and fatigue in the legs. The patient was diagnosed as severe aplastic anemia and treatment was started with metenolone and steroid pulse therapy. Administration of antibiotics and granulocyte-colony stimulating factor which led to a resolution of the high fever. About four months after admission, the patient developed vomiting and abdominal pain with a spiking fever. The next day after suddenly losing consciousness, she died. B. cereus was isolated from blood cultures. Autopsy specimens of the liver, cardiac muscle and lung showed changes due to B. cereus. This pathogen is widely distributed in nature. We should not overlook B. cereus as a contamination, but rather should consider it a potential pathogen in immunocompromised hosts, when it is isolated from blood cultures. 相似文献