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71.
Patrick Verdonck Vladimir Šamara Alec GoodyearAbdelkarim Ferchichi Els Van BesienMikhail R. Baklanov Nicholas Braithwaite 《Thin solid films》2011,520(1):464-468
In this study, special tests were devised in order to investigate the influence of ion bombardment on the damage induced in low-k dielectrics by oxygen plasmas. By placing a sample that suffered a lot of ion bombardment and one which suffered little ion bombardment simultaneously in the same plasma, it was possible to verify that ion bombardment in fact helped to protect the low-k film against oxygen plasma induced damage. Exhaustive analyses (ellipsometry, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, porosimetry, capacitance-voltage (C-V) measurements, water contact angle analysis) show that ion bombardment induced the formation of a denser top layer in the film, which then hampered further penetration of active oxygen species deeper into the bulk. This was further confirmed by other tests combining capacitively and inductively coupled plasmas. Therefore, it was possible to conclude that, at least for these plasmas, ion bombardment may help to reduce plasma induced damage to low-k materials. 相似文献
72.
Joanna K. Ledwon Sarah A. Applebaum Bianka Progri Oveyaa Vignesh Kristof S. Gutowski Alec B. Chang Adrian B. Tepole Arun K. Gosain 《International journal of molecular sciences》2022,23(21)
Tissue expansion is an integral procedure of the vast majority of breast reconstruction and has a significant impact on the final clinical outcomes. Therefore, technological advances leading to a fewer number of unfavorable outcomes and a decrease in complication rates are imperative. In this study, using a porcine model, we investigated an effect of acellular dermal matrix (ADM) used as a tissue expander cover on the dermal changes induced by mechanical forces during tissue expansion. After 14 days of expansion, skin samples were collected from one animal, while the second animal underwent radiation, and tissue was collected 8 weeks later. Tissue expanded without the use of ADM and unexpanded skin served as the controls. Collected skin biopsies were used for histological and immunohistochemical evaluation, and for gene expression analysis. We revealed that the biological cover incorporation into host tissue is facilitated by macrophages without inducing a broad inflammatory response. The utilization of ADM mitigated disruption in the dermal structure, excessive collagen deposition, and capsule formation in non-irradiated expanded skin. The protective effect was not fully maintained in irradiated skin. These results demonstrate that tissue expansion might be improved by using the tissue expander cover. 相似文献
73.
74.
Tucker Alec D.; Baty Daniel; Parker Michael W.; Pattus Franc; Lazdunski Claude; Tsernoglou Demetrius 《Protein engineering, design & selection : PEDS》1989,2(6):399-405
Colicins are antibiotic proteins that kill sensitive Escherichiacoli cells. The structure of the pore-forming fragment of colicinA has been solved to 2.5 A resolution using the techniques ofX-ray crystallography and genetic engineering. Site-directedmutagenesis was used to construct a number of cysteine-containingmutant proteins, one of which yielded an excellent mercurialderivative. Our experiences suggest strategies for obtaininguseful heavy-atom derivatives for protein crystallography usinggenetic engineering techniques. 相似文献
75.
Alec Mitchell Bernardo Hernandez-Morales 《Metallurgical and Materials Transactions B》1990,21(4):723-731
An alternating current (AC)-operated electromagnetic stirring (EMS) device, using line frequency, was designed and built to
operate on a laboratory electroslag remelting (ESR) furnace for 150-mm-diameter ingots. Laboratory-scale experiments were
conducted employing both 4340 alloy steel and INCONEL 718 alloy as electrode material. The initiation of stirring is accompanied
by a thin strip of segregated material and favors the formation of spot segregation. Changes produced in the fluid flow conditions
in the liquid pool ahead of the solidification front result in a transition from a highly directional columnar to an unoriented,
branched structure. Except for small pockets of segregated liquid, the flow of molten metal does not penetrate into the mushy
zone. Both electrode material and molten metal pool shape play an important role on the extent of promoting an equiaxed structure. 相似文献
76.
77.
It is felt that stress fractures are caused by excessive, repetitive muscle forces acting across the affected bone. These fractures should be suspected in participants of athletic endeavors who present with a history of persistent, focal, activity-related pain regardless of their stage of physical conditioning. Associated physical findings are localized tenderness and swelling without evidence of a generalized systemic response. Bone scans and serial roentgenograms including specialized views may be required for documentation. Limitation of the athletic activity is the hallmark of the treatment program. 相似文献
78.
The possibility of providing cooling and air conditioning by means of energy from the sun has attracted Man's attention since the early development of solar technology. This article attempts to describe the present state of the art in solar cooling technology. A survey is given of the vast amount of research, development and engineering work done to date in this field. The various approaches to solar cooling and the different operating systems are considered, including heat engine driven vapor compression, absorption, ejector and desiccant cooling. A comparison between the different methods and processes is given and the appropriate applications are discussed. 相似文献
79.
Büchler P Simon A Burger J Ginggen A Crivelli R Tardy Y Luechinger R Olsen S 《IEEE transactions on bio-medical engineering》2007,54(4):726-733
The goal of this study was to propose a general numerical analysis methodology to evaluate the magnetic resonance imaging (MRI)-safety of active implants. Numerical models based on the finite element (FE) technique were used to estimate if the normal operation of an active device was altered during MRI imaging. An active implanted pump was chosen to illustrate the method. A set of controlled experiments were proposed and performed to validate the numerical model. The calculated induced voltages in the important electronic components of the device showed dependence with the MRI field strength. For the MRI radiofrequency fields, significant induced voltages of up to 20 V were calculated for a 0.3T field-strength MRI. For the 1.5 and 3.0OT MRIs, the calculated voltages were insignificant. On the other hand, induced voltages up to 11 V were calculated in the critical electronic components for the 3.0T MRI due to the gradient fields. Values obtained in this work reflect to the worst case situation which is virtually impossible to achieve in normal scanning situations. Since the calculated voltages may be removed by appropriate protection circuits, no critical problems affecting the normal operation of the pump were identified. This study showed that the proposed methodology helps the identification of the possible incompatibilities between active implants and MR imaging, and can be used to aid the design of critical electronic systems to ensure MRI-safety. 相似文献
80.
The design of a curb is straight forward. The curb itself provides a conveyance of stormwater, facilitating the movement of water and pollutants from the street into waterways. Pollutants such as sediment, nutrients from lawn fertilizers, bacteria, viruses, pesticides, metals, and petroleum byproducts accumulate on the road surface and are released during storm events, carried to storm drains, and deposited into waterways, often without treatment. Once pollutants enter the waterways they impact the ecosystem and affect water quality. How can discrete standards—like a curb—be leveraged to have larger systemic impacts? The redesign of the curb to perform as a magnet for pollutants can challenge this design standard. During the summer of 2019, the interdisciplinary research team tested alternatives to the standard concrete curb and apron at Ohio State University. The team used an iterative design process to add patterning and crenellations to the face of the curb and apron. Using full scale models to test simulated storm events, the team collected data to evaluate the performance of 21 alternative designs. The results suggest the new combined curb and apron designs can abstract pollutants from roadways before they are detrimental to water bodies and aquatic ecosystems. 相似文献