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排序方式: 共有443条查询结果,搜索用时 0 毫秒
61.
Fabricio Alcalde Bessia Martin Pérez José Lipovetzky Natalia Alejandra Piunno Horacio Mateos Iván Sidelnik Juan Jerónimo Blostein Miguel Sofo Haro Mariano Gómez Berisso 《International Journal of Circuit Theory and Applications》2018,46(10):1848-1857
This paper presents the use of commercial off the shelf CMOS image sensors for the acquisition of X‐ray images with high spatial resolution. The X‐ray images, with application in biology, electronic components inspection, and paleontology research, are obtained with 8‐keV photons from a Cu tube. The quantum efficiency of the detector is estimated using attenuation lengths of photons in the sensor and compared to traditional scintillator conversion layers. The spatial resolution observed with the sensor is limited by the charge redistribution produced after photon interaction with Si. 相似文献
62.
Cytotoxic Activity and Structure–Activity Relationship of Triazole‐Containing Bis(Aryl Ether) Macrocycles
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Dr. Eduardo Hernández‐Vázquez Dr. Alejandra Chávez‐Riveros Dr. Adriana Romo‐Pérez María Teresa Ramírez‐Apán Dr. Alma D. Chávez‐Blanco Dr. Rocío Morales‐Bárcenas Dr. Alfonso Dueñas‐González Dr. Luis D. Miranda 《ChemMedChem》2018,13(12):1193-1209
Cancer continues to be a worldwide health problem. Certain macrocyclic molecules have become attractive therapeutic alternatives for this disease because of their efficacy and, frequently, their novel mechanisms of action. Herein, we report the synthesis of a series of 20‐, 21‐, and 22‐membered macrocycles containing triazole and bis(aryl ether) moieties. The compounds were prepared by a multicomponent approach from readily available commercial substrates. Notably, some of the compounds displayed interesting cytotoxicity against cancer (PC‐3) and breast (MCF‐7) cell lines, especially those bearing an aliphatic or a trifluoromethyl substituent on the N‐phenyl moiety (IC50<13 μm ). Additionally, some of the compounds were able to induce apoptosis relative to the solvent control; in particular, (Z)‐N‐cyclohexyl‐7‐oxo‐6‐[4‐(trifluoromethyl)phenyl]‐11H‐3,10‐dioxa‐6‐aza‐1(4,1)‐triazola‐4(1,3),9(1,4)‐dibenzenacyclotridecaphane‐5‐carboxamide ( 12 f ) was the most potent in this regard (22.7 % of apoptosis). 相似文献
63.
Ndieyira JW Watari M Barrera AD Zhou D Vögtli M Batchelor M Cooper MA Strunz T Horton MA Abell C Rayment T Aeppli G McKendry RA 《Nature nanotechnology》2008,3(11):691-696
The alarming growth of the antibiotic-resistant superbugs methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) is driving the development of new technologies to investigate antibiotics and their modes of action. We report the label-free detection of vancomycin binding to bacterial cell wall precursor analogues (mucopeptides) on cantilever arrays, with 10 nM sensitivity and at clinically relevant concentrations in blood serum. Differential measurements have quantified binding constants for vancomycin-sensitive and vancomycin-resistant mucopeptide analogues. Moreover, by systematically modifying the mucopeptide density we gain new insights into the origin of surface stress. We propose that stress is a product of a local chemical binding factor and a geometrical factor describing the mechanical connectivity of regions activated by local binding in terms of a percolation process. Our findings place BioMEMS devices in a new class of percolative systems. The percolation concept will underpin the design of devices and coatings to significantly lower the drug detection limit and may also have an impact on our understanding of antibiotic drug action in bacteria. 相似文献
64.
Diego Nocetti Hipólito Núñez Luis Puente Alejandra Espinosa Fernando Romero 《Journal of the science of food and agriculture》2020,100(12):4335-4346
Goldenberry is a wild fruit that has been widely used for centuries, mainly in folk medicine. Most studies of goldenberry have focused on the fruit, but new research has studied its byproducts, which were considered to be waste until recently. The main objective of our study was to systematize the published information regarding the composition of goldenberry byproducts (calyces, leaves, seeds, and pomace) and their effects on biological systems. Goldenberry byproducts contain minerals, amino acids, withanolides, flavonoids, and essential fatty acids, thus representing good sources of these compounds. Some of their major biological effects include anti-inflammatory, antioxidant, antidiabetic, and antiproliferative effects. Information regarding their toxicity is also presented here. To determine the optimal dosage, further safety studies would be recommended to ensure the best health benefits of these compounds. The available evidence has demonstrated the nutritional value of different byproducts of goldenberry, suggesting them to be potential candidates for use in the cosmetic industry, in the preparation of functional foods, and in phytomedicine for the prevention and adjuvant treatment of some diseases. © 2020 Society of Chemical Industry 相似文献
65.
Blends of linear low density polyethylene (LLDPE) and LLDPE grafted maleic anhydride (LLDPE‐g‐MA) were prepared by melt mixing. The surface of cast films with different contents and types of maleated PE were characterized through contact angle and wetting tension measurements, as well as attenuated total reflection IR spectroscopy. The tensile properties and light transmission of extruded films, as well as the performance of these films compared with commercial “antifog” films, for greenhouses were determined. The carbonyl polar groups on the surface of LLDPE/LLDPE‐g‐MA blends increased, and the equilibrium contact angles of water and dimethylformamide decreased when the content of maleated PE increased. Films made with these blends showed a noticeable reduction in water drop formation as the MA content was increased and when using LLDPE‐g‐MA of lower molecular weight. The light transmission through these films under condensation was improved when using increased contents of MA, which promotes better wetting of the water on the surface. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 79: 1802–1808, 2001 相似文献
66.
67.
DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array. 相似文献
68.
Alejandra M. Gonzalez-Mejia Tarsha Eason Heriberto Cabezas Makram T. Suidan 《Clean Technologies and Environmental Policy》2012,14(5):775-788
As a key tool in information theory, Fisher Information has been used to explore the observable behavior of a variety of systems. In particular, recent work has demonstrated its ability to assess the dynamic order of real and model systems. However, in order to solidify the use of this metric for measuring sustainability, it is pertinent that Fisher Information be understood both conceptually and practically. As such, this document has been developed as a guide for interpreting Fisher Information as sustainability metric. Moreover, this study provides details on an analytical and numerical approach to estimating Fisher information based on the evaluation of changes in the system’s trajectory for determining stable and unstable regimes in real systems, which might represent sustainable or unsustainable systems. Using this novel approach, the sustainability of US air quality characterized by criteria pollutants (i.e., lead, carbon monoxide, ozone, nitrogen dioxide, and sulfur dioxide) was assessed from 1980 to 2009. Further, the precision of Fisher Information computations was examined, thereby establishing an alternative procedure for evaluating real systems characterized by noisy and sparse datasets. Throughout this article, the reader is led through the analysis of Fisher Information results with the goal of both providing guidance on the interpretation of Fisher Information and giving a more tactile understanding of the results applied to sustainability assessment. 相似文献
69.
Alejandra Montenegro-Hernández Jesús Vega-Castillo Liliana Mogni Alberto Caneiro 《International Journal of Hydrogen Energy》2011,36(24):15704-15714
Thermal stability and chemical compatibility with electrolyte materials for Solid Oxide Fuel Cells (SOFC) have been studied on Ruddlesden-Popper nickelates Ln2NiO4+δ with Ln: La, Pr and Nd. Samples of each composition prepared by three different routes, were characterized by X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). Different microstructures were achieved by each preparation method. The thermal stability of these compounds was analyzed by annealing all the samples at 700 and 900 °C in air. Pr2NiO4+δ (PNO) decomposes after 24 h of annealing at 700 °C confirming its instability at these conditions. Evidences of chemical reaction between La2NiO4+δ (LNO) and both Ce0.9Gd0.1O1.96 (CGO) and Zr0.92Y0.08O1.96 (YSZ) were observed at 700 and 900 °C, respectively. No decomposition or chemical reaction with YSZ or CGO were found for Nd2NiO4+δ (NNO) below 900 °C. Nevertheless, reactivity with both electrolytes was found for this compound at 1000 °C. The kinetics of these reactions strongly depends on the microstructure of Ln2NiO4+δ. 相似文献
70.