Design and characterization of a current sensing platform for silicon-based nanopores with integrated tunneling nanoelectrodes

Solid-state nanopores have been gaining popularity in nano-biotechnology for single molecule detection, in particular for label-free high-throughput DNA sequencing. In order to address the improvement of the resolution/speed trade-off critical in this application, here we present a new two-channel current amplifier tailored for solid-state nanopore devices with integrated tunneling electrodes. The simultaneous detection of ion and tunneling currents provides enhanced molecule tracking capability. We describe the system design starting from a detailed noise analysis and device modeling, highlighting the detrimental role of the conductive silicon substrate and of all the stray capacitive couplings between the electrodes. Given the high input capacitance (0.1–1 nF), the input voltage noise has been carefully minimized choosing a discrete couple of matched low-noise JFETs as input stage, thus achieving an equivalent input noise of 1.5 nV/√Hz (corresponding to a current noise floor of 15 fA/√Hz at 10 kHz). Low-noise performance (11 pA rms noise integrated over a 75 kHz bandwidth) is preserved at a wide bandwidth (300 kHz) and high gain (100 MΩ) thanks to the adoption of an improved integrator/differentiator cascade topology. Furthermore, along with biasing networks and selectable low-pass filters, an AC-coupled channel providing additional gain has been introduced in order to “zoom” in the current signature during pore blockade events. Together with an experimental characterization of the system (and comparison with the noise performance of other instruments), the platform is validated by demonstrating the detection of λ-DNA with 20 nm pores.     

Localization of electrical-insulation and partial-dischargefailures of IGBT modules

The partial discharge (PD) and insulation resistance is very important in view of the increasing operating voltages of insulated gate bipolar transistor modules. PD spectroscopy showed that the PDs from metallization edges and interfaces in silicone gel were the main sources of PD at high voltages. It also allows these types of PDs to be clearly distinguished. As the PDs from interfaces in silicone gel increase strongly at high voltages, it is especially important for the silicone gel to adhere well to the ceramic     

Dynamic diffusion model for tracing the real-time potential response of polymeric membrane ion-selective electrodes

A numerical solution for the prediction of the time-dependent potential response of a polymeric-based ion-selective electrode (ISE) is presented. The model addresses short- and middle-term potential drifts that are dependent on changes in concentration gradients in the aqueous sample and organic membrane phase. This work has important implications for the understanding of the real-time response behavior of potentiometric sensors with low detection limits and with nonclassical super-Nernstian response slopes. As a model system, the initial exposure of membranes containing the well-examined silver ionophore O,O' '-bis[2-(methylthio)ethyl]-tert-butylcalix[4]arene was monitored, and the large observed potential drifts were compared to theoretical predictions. The model is based on an approximate solution of the diffusion equation for both aqueous and organic diffusion layers using a numerical scheme (finite difference in time and finite elements in space). The model may be evaluated on the basis of experimentally available parameters and gives time-dependent information previously inaccessible with a simpler steady-state diffusion model. For the cases studied, the model gave a very good correlation with experimental data, albeit with lower than expected diffusion coefficients for the organic phase. This model may address numerous open questions regarding the response time and memory effects of low-detection-limit ion-selective electrodes and for other membrane electrodes where ion fluxes are relevant.     

Der Einfluß von Bariumoxid auf die Zähigkeit von Hochofenschlacken

Messung der Zähigkeit der Hochofenschlacken mit einem Massengehalt von 0 bis 14% BaO. Änderung der Aktivierungsenergie des viskosen Fließens mit steigendem Anteil an Bariumoxid. Veränderungen der Schlackenstruktur sowie Entmischungen und Abweichungen der chemischen Zusammensetzung in Mikrobereichen bei Erhöhung der Bariumoxidgehalte.     

Modeling diffraction in free-space optical interconnects by the mode expansion method

Free-space optical interconnects (FSOIs), made up of dense arrays of vertical-cavity surface-emitting lasers, photodetectors and microlenses can be used for implementing high-speed and high-density communication links, and hence replace the inferior electrical interconnects. A major concern in the design of FSOIs is minimization of the optical channel cross talk arising from laser beam diffraction. In this article we introduce modifications to the mode expansion method of Tanaka et al. [IEEE Trans. Microwave Theory Tech. MTT-20, 749 (1972)] to make it an efficient tool for modelling and design of FSOIs in the presence of diffraction. We demonstrate that our modified mode expansion method has accuracy similar to the exact solution of the Huygens-Kirchhoff diffraction integral in cases of both weak and strong beam clipping, and that it is much more accurate than the existing approximations. The strength of the method is twofold: first, it is applicable in the region of pronounced diffraction (strong beam clipping) where all other approximations fail and, second, unlike the exact-solution method, it can be efficiently used for modelling diffraction on multiple apertures. These features make the mode expansion method useful for design and optimization of free-space architectures containing multiple optical elements inclusive of optical interconnects and optical clock distribution systems.     

On the Feedback Capacity of Power-Constrained Gaussian Noise Channels With Memory

For a stationary additive Gaussian-noise channel with a rational noise power spectrum of a finite-order L, we derive two new results for the feedback capacity under an average channel input power constraint. First, we show that a very simple feedback-dependent Gauss-Markov source achieves the feedback capacity, and that Kalman-Bucy filtering is optimal for processing the feedback. Based on these results, we develop a new method for optimizing the channel inputs for achieving the Cover-Pombra block-length- n feedback capacity by using a dynamic programming approach that decomposes the computation into n sequentially identical optimization problems where each stage involves optimizing O(L ²) variables. Second, we derive the explicit maximal information rate for stationary feedback-dependent sources. In general, evaluating the maximal information rate for stationary sources requires solving only a few equations by simple nonlinear programming. For first-order autoregressive and/or moving average (ARMA) noise channels, this optimization admits a closed-form maximal information rate formula. The maximal information rate for stationary sources is a lower bound on the feedback capacity, and it equals the feedback capacity if the long-standing conjecture, that stationary sources achieve the feedback capacity, holds     

A CALCULATION METHOD OF OBTAINING DESORPTION ISOTHERMS OF BEECH (FAGUSMOESL4CA) WOOD

ABSTRACT

This paper presents the specific methods to obtain sorption isotherms. Sorption isotherms were first obtained experimentally for 20°C and 100°C and then, by using the presented method, isotherms were also obtained for 50°C and 80°C. The same treatment can be applied in finding any isotherm sorption in the temperature range between 20°Cand 100°C.

The experiments were carried out on beech (Fagus moesiaca) and sample dimensions were 3×3×3cm. Based on the results of the experiment, by regression analysis, the most suitable analytic formula was proposed. It relsites temperature and air humidity with the equilibrium moisture content in wood. Experimental results were compared with psychrometric tables and Bramhall's formula for desorption curves with good agreement. This proves that the method presented in this paper is precise and efficient to decrease the lime needed to obtain sorption isotherms experimentally.     

Fully-Naphthalenoid Hydrocarbons and their Conjugation Modes

Abstract

A fully-naphthalenoid hydrocarbon (FUN) is a benzenoid hydrocarbon whose all π-electrons can be (formally) grouped into disjoint naphthalene-units. The cyclic conjugation in FUNs is studied by means of the energy-effects of their various cycles. It is found that the dominant conjugation modes in FUNs are those involving the 6- and 10-membered cycles of the “full” naphthalene fragments. The cycles belonging to the “empty” domains of a FUN have significantly smaller energy-effects.     

Some engineering properties of limestone: Tunnel Stra?ina case study (Croatia)

The paper presents geological and engineering geological characteristics of the Stra?ina Tunnel along the Bisko-Šestanovac section of the Zagreb-Split-Dubrovnik highway in Croatia. This paper compares the actual conditions of the rock mass during the excavation with a prediction model that preceded the excavation. From the engineering-geological viewpoint the rock mass in the tunnel was of a significantly higher quality than the prediction model. The specific geological feature of the Stra?ina Tunnel, with its right and left tunnel tube, is the passage of the right tunnel tube through a transgressive contact between Upper Cretaceous rudist limestones and Eocene foraminiferal limestones. Since this is the only tunnel in Croatia excavated through this particular transgressive contact, the geological and engineering properties of the transgression zone were up to now only assumed. Therefore, additional mineralogical, petrographical and engineering geological observations were carried out in order to determine and describe the transgression zone. The results are presented in this paper. In the left tunnel tube the contact between the mentioned litostratigraphical Units is of the fault type. This paper also briefly deals with the significance and cause of the overprofile excavation during tunneling through strongly karstified carbonate rocks. Consequently, special attention was paid to the overprofile during excavation since it can significantly affect tunneling costs.