Cardiovascular function and brain metabolites in normal weight and intrauterine growth restricted newborn piglets--effect of mild hypoxia

In order to clarify the influence of intrauterine growth restriction on systemic hemodynamics, catecholamine response, and regional distribution of brain energy metabolites per se and during mild hypoxic episodes a study was performed in thirty newborns with a well-characterized state of intrauterine and intra-natal development. Thirty animals were divided into fifteen normal weight piglets (NW) and fifteen intrauterine growth restricted (IUGR) piglets according to their birth weight. Category "NW" covered animals with a birth weight of > 40th percentile; IUGR category covered animals with a birth weight of > 5th and < 10th percentiles. Animals were anesthetized with halothane in 70% nitrous oxide and 30% oxygen and after immobilization artificially ventilated. The acid-base balance and blood gas values at baseline conditions were similar within the different groups investigated and consistent with other data obtained from anesthetized and artificially ventilated newborn piglets. Mild hypoxic hypoxia which was induced by lowering the FiO2 from 0.35 to 0.15 resulted in reduced arterial pO2 (NW: from 115 +/- 37 mmHg to 39 +/- 7 mmHg; IUGR: from 117 +/- 23 mmHg to 39 +/- 3 mmHg; p < 0.05), but arterial pH and pCO2 remained unchanged. Under baseline conditions arterial blood pressure, cardiac output, and myocardial contractility, expressed as dp/dt(max) and plasma catecholamine values were similar in all groups studied. Heart rate was slightly increased in IUGR (p < 0.05). Mild hypoxia led to a strong increase of myocardial contractility in NW as well as IUGR piglets to 2.4 and 2.7 fold and remained increased during recovery (p < 0.05). Moreover, total peripheral resistance was enhanced at the end of recovery period in IUGR animals (p < 0.05). There was a significant increase of epinephrine (E) in NW animals in comparison to sham-operated animals (p < 0.05). Interestingly, during reoxygenation the further increase in E and norepinephrine (NE) levels were enhanced in the animals which suffered from mild hypoxia (p < 0.05). Regional distribution of brain tissue metabolites was partly affected by intrauterine growth restriction. In particular, brain tissue glucose content was strongly reduced by 65 to 72 per cent in all brain regions investigated. Mild hypoxia led to an increase of about 30 percent in NW animals (p < 0.05). In IUGR piglets the percentage increase of brain glucose content was on an average more pronounced but with considerably higher variance. Also, a strong increase of brain lactate content appeared here (p < 0.05). In contrast, brain tissue ATP was quite similar in all groups studied, but brain creatine phosphate was significantly reduced in some forebrain structures of IUGR piglets after mild hypoxia (figure 2, p < 0.05). In summary, this investigation provides information on cardiovascular functions and brain metabolites of normal weight and naturally occurring growth restricted newborn piglets. Mild hypoxemia was well-tolerated from both animal groups. It is suggested that lactate may play a significant role as a source for brain energy production in the newborn IUGR piglets.     

Inter-image outliers and their application to image classification

Image variability that is impossible or difficult to restore by intra-image processing, such as the variability caused by occlusions, significantly reduces the performance of image-recognition methods. To address this issue, we propose that the pixels associated with large distances obtained by inter-image pixel-by-pixels comparisons should be considered as inter-image outliers and should be removed from the similarity calculation used for the image classification. When this method is combined with the template-matching method for image recognition, it leads to state-of-the-art recognition performance: 91% with AR database that includes occluded face images, 90% with PUT database that includes pose variations of face images and 100% with EYale B database that includes images with large illumination variation.     

Managing cohort movement of mobile sensors via GPS-free and compass-free node localization

A critical problem in mobile ad hoc wireless sensor networks is each node’s awareness of its position relative to the network. This problem is known as localization. In this paper, we introduce a variant of this problem, directional localization, where each node must be aware of both its position and orientation relative to its neighbors. Directional localization is relevant for applications that require uniform area coverage and coherent movement. Using global positioning systems for localization in large scale sensor networks may be impractical in enclosed spaces, and might not be cost effective. In addition, a set of pre-existing anchors with globally known positions may not always be available. In this context, we propose two distributed algorithms based on directional localization that facilitate the collaborative movement of nodes in a sensor network without the need for global positioning systems, seed nodes or a pre-existing infrastructure such as anchors with known positions. Our first algorithm, GPS-free Directed Localization (GDL) assumes the availability of a simple digital compass on each sensor node. We relax this requirement in our second algorithm termed GPS- and Compass-free Directed Localization (GCDL). Through experimentation, we demonstrate that our algorithms scale well for large numbers of nodes and provide convergent localization over time, despite errors introduced by motion actuators and distance measurements. In addition, we introduce mechanisms to preserve swarm formation during directed sensor network mobility. Our simulations confirm that, in a number of realistic scenarios, our algorithms provide for a mobile sensor network that preserves its formation over time, irrespective of speed and distance traveled. We also present our method to organize the sensor nodes in a polygonal geometric shape of our choice even in noisy environments, and investigate the possible uses of this approach in search-and-rescue type of missions.     

Evidential reasoning using extended fuzzy Dempster–Shafer theory for handling various facets of information deficiency

This work investigates the problem of combining deficient evidence for the purpose of quality assessment. The main focus of the work is modeling vagueness, ambiguity, and local nonspecificity in information within a unified approach. We introduce an extended fuzzy Dempster–Shafer scheme based on the simultaneous use of fuzzy interval‐grade and interval‐valued belief degree (IGIB). The latter facilitates modeling of uncertainties in terms of local ignorance associated with expert knowledge, whereas the former allows for handling the lack of information on belief degree assignments. Also, generalized fuzzy sets can be readily transformed into the proposed fuzzy IGIB structure. The reasoning for quality assessment is performed by solving nonlinear optimization problems on fuzzy Dempster–Shafer paradigm for the fuzzy IGIB structure. The application of the proposed inference method is investigated by designing a reasoning scheme for water quality monitoring and validated through the experimental data available for different sampling points in a water distribution network. © 2011 Wiley Periodicals, Inc.     

Reconfigurable distributed storage for dynamic networks

This paper presents a new algorithm for implementing a reconfigurable distributed shared memory in an asynchronous dynamic network. The algorithm guarantees atomic consistency (linearizability) in all executions in the presence of arbitrary crash failures of the processing nodes, message delays, and message loss. The algorithm incorporates a classic quorum-based algorithm for read/write operations, and an optimized consensus protocol, based on Fast Paxos for reconfiguration, and achieves the design goals of: (i) allowing read and write operations to complete rapidly and (ii) providing long-term fault-tolerance through reconfiguration, a process that evolves the quorum configurations used by the read and write operations. The resulting algorithm tolerates dynamism. We formally prove our algorithm to be correct, we present its performance and compare it to existing reconfigurable memories, and we evaluate experimentally the cost of its reconfiguration mechanism.     

A queue based mutual exclusion algorithm

A new elegant and simple algorithm for mutual exclusion of N processes is proposed. It only requires shared variables in a memory model where shared variables need not be accessed atomically. We prove mutual exclusion by reformulating the algorithm as a transition system (automaton), and applying simulation of automata. The proof has been verified with the higher-order interactive theorem prover PVS. Under an additional atomicity assumption, the algorithm is starvation free, and we conjecture that no competing process is passed by any other process more than once. This conjecture was verified by model checking for systems with at most five processes.     

Platform‐independent profiling in a virtual execution environment

Virtual execution environments, such as the Java virtual machine, promote platform‐independent software development. However, when it comes to analyzing algorithm complexity and performance bottlenecks, available tools focus on platform‐specific metrics, such as the CPU time consumption on a particular system. Other drawbacks of many prevailing profiling tools are high overhead, significant measurement perturbation, as well as reduced portability of profiling tools, which are often implemented in platform‐dependent native code. This article presents a novel profiling approach, which is entirely based on program transformation techniques, in order to build a profiling data structure that provides calling‐context‐sensitive program execution statistics. We explore the use of platform‐independent profiling metrics in order to make the instrumentation entirely portable and to generate reproducible profiles. We implemented these ideas within a Java‐based profiling tool called JP. A significant novelty is that this tool achieves complete bytecode coverage by statically instrumenting the core runtime libraries and dynamically instrumenting the rest of the code. JP provides a small and flexible API to write customized profiling agents in pure Java, which are periodically activated to process the collected profiling information. Performance measurements point out that, despite the presence of dynamic instrumentation, JP causes significantly less overhead than a prevailing tool for the profiling of Java code. Copyright © 2008 John Wiley & Sons, Ltd.     

Structural reliability assessment based on probability and convex set mixed model

This paper investigates the reliability assessment of structures exhibiting both stochastic and bounded uncertainties by using a probability and convex set mixed model. The safety measure of a structure is quantified by a reliability index defined by a nested minimization problem. An iterative procedure is developed for seeking the worst-case point and the most probable failure point in the standard uncertainty space. Numerical examples are given to demonstrate the applicability of the probability and convex set mixed model representation in the structural reliability assessment, as well as to illustrate the validity and effectiveness of the proposed numerical method.     

Complete discriminant evaluation and feature extraction in kernel space for face recognition

This work proposes a method to decompose the kernel within-class eigenspace into two subspaces: a reliable subspace spanned mainly by the facial variation and an unreliable subspace due to limited number of training samples. A weighting function is proposed to circumvent undue scaling of eigenvectors corresponding to the unreliable small and zero eigenvalues. Eigenfeatures are then extracted by the discriminant evaluation in the whole kernel space. These efforts facilitate a discriminative and stable low-dimensional feature representation of the face image. Experimental results on FERET, ORL and GT databases show that our approach consistently outperforms other kernel based face recognition methods.