俄亥俄州大学医院阿胡亚医疗中心

<正>项目名称:俄亥俄州大学医院阿胡亚医疗中心业主:俄亥俄州大学医院阿胡亚医疗中心建设地点:3995 Richmond Road Beachwood,Ohio,44122,USA设计单位:HKS,Inc.合作单位:ARRAY Healthcare Facilities Solutions设计总负责:王翔(Alex Wang)设计顾问:ccrd partners(机电工程);HKS,Inc.(结构工程,医疗设备规划);Michael BenzaAssociates,Inc.(土木工程)用地面积:17 hm2建筑面积:3.5万m2手术室数量:8床位数:144     

Magnetic field effects as a result of the radical pair mechanism are unlikely in redox enzymes

Environmental exposure to electromagnetic fields is potentially carcinogenic. The radical pair mechanism is considered the most feasible mechanism of interaction between weak magnetic fields encountered in our environment and biochemical systems. Radicals are abundant in biology, both as free radicals and reaction intermediates in enzyme mechanisms. The catalytic cycles of some flavin-dependent enzymes are either known or potentially involve radical pairs. Here, we have investigated the magnetic field sensitivity of a number of flavoenzymes with important cellular roles. We also investigated the magnetic field sensitivity of a model system involving stepwise reduction of a flavin analogue by a nicotinamide analogue—a reaction known to proceed via a radical pair. Under the experimental conditions used, magnetic field sensitivity was not observed in the reaction kinetics from stopped-flow measurements in any of the systems studied. Although widely implicated in radical pair chemistry, we conclude that thermally driven, flavoenzyme-catalysed reactions are unlikely to be influenced by exposure to external magnetic fields.