Application of an improved operational strategy on a PBI fuel cell-based residential system for Danish single-family households

A proposed residential energy system based on the PBI (Polybenzimidazole) fuel cell technology is analyzed in terms of operational performance. Conventional operational strategies, such as heat-led and electricity-led, are applied to the simulated system to investigate their performance characteristics. Based on these findings, an improved operational strategy is formulated and applied in an attempt to minimize the shortcomings of conventional strategies. System parameters, such as electrical and thermal efficiencies, heat dumping, and import/export of electricity, are analyzed. The applied load profile is based on average data for a single-family household in Denmark and includes consumption data for electricity and heat demands. The study analyzes the potential of the proposed system on market penetration in the area of residential heat-and-power generation and whether this deployment can be justified as compared to other micro-CHP system technologies. The most important findings of this research study indicate that in comparison to non-fuel cell-based micro-CHP systems, such as Stirling Engine-based systems, the proposed system has significantly higher efficiencies. Moreover, the lower heat-to-power ratios allow the system to avoid high thermal surpluses throughout the whole annual operational profile.     

Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening

Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) and A2780 (cisplatin-sensitive) ovarian carcinoma cell lines were used. The cytotoxic effect of MMP-9/MMP-2 inhibitor, (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) alone or in combination with cisplatin was determined using high content screening. Protein expression was examined using immunohistochemistry and ELISA. Co-incubation of cisplatin and an MMP-9/MMP-2 inhibitor, (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) resulted in significantly greater cytotoxicity as compared to either treatment alone in a cisplatin resistant MMP-9 overexpressing cell line; A2780cis. In addition, pre-incubating with MMP-9i prior to cisplatin further enhances the cytotoxic effect. No significant difference was observed in MMP-9 protein in tissue but a trend towards increased MMP-9 was observed in recurrent serum. We propose that MMP-9/MMP-2i may be utilized in the treatment of recurrent/chemoresistant ovarian cancers that overexpress MMP-9 mRNA but its role in vivo remains to be evaluated.     

Optimal probabilistic design of seismic dampers for the protection of isolated bridges against near-fault seismic excitations

A probabilistic, simulation-based framework is presented in this paper for risk assessment and optimal design of supplemental dampers for multi-span bridge systems supported on abutments and intermediate piers through isolation bearings. The adopted bridge model explicitly addresses nonlinear characteristics of the isolators and the dampers, the dynamic behavior of the abutments, and the effect of pounding between the neighboring spans against each other as well as against the abutments. Nonlinear dynamic analysis is used to evaluate the bridge performance, and a realistic stochastic ground motion model is presented for describing the time history of future near-fault ground motions and relating their characteristics to the seismic hazard for the structural site. A probabilistic foundation is used to address the various sources of structural and excitation uncertainties and ultimately characterize the seismic risk for the bridge. This risk is given by the expected value of the system response over the adopted probability models. Stochastic simulation is used for evaluating the multi-dimensional integral representing this expected value and for performing the associated optimization when searching for the most favorable damper characteristics. An efficient probabilistic sensitivity analysis is also established for identifying the importance of each of the uncertain model parameters in affecting the overall risk. An illustrative example is presented that considers the design of nonlinear viscous dampers for the protection of a two-span bridge.     

Platelet‐activating factor detection,metabolism, and inhibitors in the ethanologenic bacterium Zymomonas mobilis

Platelet‐activating factor (PAF) is a signaling phospholipid with a significant physiological role in multicellular and unicellular organisms, including fermentative organisms such as yeast. Zymomonas mobilis is an ethanologenic α‐proteobacterium currently studied for bioethanol production. In order to examine the presence of PAF and/or PAF inhibitors in Z. mobilis, a new one‐step high performance liquid chromatography (HPLC) separation procedure of total lipids was performed, using a C8 reversed‐phase semi‐preparative column. According to this method and to bioassays based on washed rabbit platelet aggregation, two lipid molecules with PAF‐like activity and same retention times as those of standard PAF were detected; electron‐spray ionization MS and MS/MS analysis revealed that they share similar structure with 16:0 and 18:0 PAF. Furthermore, other lipids extracted from Z. mobilis were found to exhibit a potent anti‐PAF activity. Enzyme activities indicative of key PAF biosynthetic enzymes, such as dithiothreitol‐insensitive cholinephosphotransferase (PAF‐CPT) and lyso‐PAF acetyltransferase were detected in Z. mobilis homogenates. As for PAF degradation, activity similar to that of PAF acetylhydrolase was also discovered. Overall, the presence of PAF, PAF‐specific inhibitors, and enzyme activities relating to PAF metabolism, suggests that PAF may play an intrinsic role in this biotechnological organism. Practical applications: Z. mobilis is a platform microorganism for bioethanol production and a potential source of high‐value chemicals of interest to the food and healthcare industries. Further investigation of PAF's role is bound to affect applications involving this and other biotechnological organisms. The finding that Z. mobilis lipids exhibit potent anti‐PAF activity opens up prospects for their identification, overproduction and pharmaceutical use. The presented HPLC method for lipid fractionation accomplishes a one‐step separation of lipids from dense samples, which may be successfully employed to other lipid‐rich sources such as blood.     

Cure kinetics,glass transition temperature development,and dielectric spectroscopy of a low temperature cure epoxy/amine system

This article reports a study of the chemical cure kinetics and the development of glass transition temperature of a low temperature (40°C) curing epoxy system (MY 750/HY 5922). Differential scanning calorimetry, temperature modulated differential scanning calorimetry, and dielectric spectroscopy were utilized to characterize the curing reaction and the development of the cross‐linking network. A phenomenological model based on a double autocatalytic chemical kinetics expression was developed to simulate the cure kinetics behavior of the system, while the dependence of the glass transition temperature on the degree of cure was found to be described adequately by the Di Benedetto equation. The resulting cure kinetics showed good agreement with the experimental data under both dynamic and isothermal heating conditions with an average error in reaction rate of less than 2 × 10^?3 min^?1. A comparison of the dielectric response of the resin with cure kinetics showed a close correspondence between the imaginary impedance maximum and the calorimetric progress of reaction. Thus, it is demonstrated that cure kinetics modeling and monitoring procedures developed for aerospace grade epoxies are fully applicable to the study of low temperature curing epoxy resins. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012     

Impact of irradiation on fish and seafood shelf life: a comprehensive review of applications and irradiation detection

Irradiation is one of the most important and effective methods towards food preservation despite the consumer lack of trust and aversion towards this method. Irradiation effectiveness greatly depends on the dose provided to food. This review aims at summarizing all available information regarding the impact of irradiation dose on the shelf life and microflora and sensory and physical properties of fish, shellfish, molluscs, and crustaceans. The synergistic effect of irradiation in conjunction with other techniques such as salting, smoking, freezing, and vacuum packaging was also reported. Another issue covered within the frame of this review is the detection (comparison of methods in terms of their effectiveness and validity) of irradiated fish and seafood. The information related to fish and seafood irradiation and its detection is presented by means of 11 comprehensive tables and 9 figures.     

Assessing the sustainability of the UK society using thermodynamic concepts: Part 2

By building on the first part of our analysis, this second part attempts to provide a further understanding of the UK society's metabolism, its impact and offer policy suggestions that could promote a shift towards sustainability. The methodologies employed in this second part include Exergy Analysis (EA) and Extended Exergy Analysis (EEA). Exergy inputs and outputs amounted to 17423.9 and 11888.7 PJ, respectively, with energy carries, mainly fossil fuels, being both the predominant inputs (15597.1 PJ) and outputs (5147.1 PJ). Exergy consumption and efficiency for various economic sectors and subsectors have been calculated with the residential and service sector showing the lowest exergy conversion efficiencies (11.2% and 12.3%, respectively) while certain industrial subsectors, such as the aluminium and iron/steel industries showed the highest exergy conversion factors (67.0 and 62.1%). Extended exergy efficiencies were somewhat different owing to the different calculation procedure. Extended exergy efficiencies were 91.4% for the extraction sector, 38.9% for the conversion sector, 49.1% for the agriculture sector, 31.5% for the transportation sector, 38.6% for the industrial sector and 80.0% for the tertiary sector.     

The impact of Energy Performance Certificates on building deep energy renovation targets

The purpose of this paper is to investigate the effect of Energy Performance Certificates (EPCs) on the renovation of buildings. Thus, through the European project ENERFUND, 2 online web-based surveys were conducted in 12 countries of the European Union. It was shown that the results varied significantly both between countries and age groups and, that, on average, EPCs did play a role both in renovation decisions and whether to rent/buy a certain flat. In addition, this paper presents major key drivers and parameters related to energy renovation investment mobilisation and suggests actions that can contribute to the promotion of investments for deep energy renovation of buildings. Furthermore, it highlights potential benefits and effectiveness of using retrofitting online tools, such as the ENERFUND tool, pinpoints market failures in the building sector and provides suggestions on increasing the deep energy renovation market in Europe.     

Retrofitting solutions for two different occupancy levels of educational buildings in tropics

Within the multi-functionality of educational buildings, the energy conservation potential can be very different. In addition, among different retrofitting solutions investigated involving interventions on the building envelope, ventilation strategies, artificial lighting systems as well as equipment upgrading, different saving potential would come from different aspects. The opportunities for energy saving potential from the overall point of view and from the detailed aspect view of different retrofitting solutions would be very useful and important for building renovation decision making. This study presents a detailed retrofitting study of two different educational buildings. One represents a building with average occupancy variation and containing mainly offices and labs. The other one represents a building with high occupancy variation and containing mainly lecture rooms and studios. This comparison of the results gives an idea of the different energy saving potential for different types of educational buildings. Principal component analysis is also adopted to investigate the detailed performance of one of the buildings which is influenced stronger by these retrofitting solutions.     

GRAMOFON: General model-selection framework based on networks

Ensembles constitute one of the most prominent class of hybrid prediction models. One basically assumes that different models compensate each other's errors if one combines them in an appropriate way. Often, a large number of various prediction models are available. However, many of them may share similar error characteristics, which highly depress the error compensation effect. Thus the selection of an appropriate subset of models is crucial. In this paper, we address this issue. As major contribution, for the case if large number of models is present, we propose a network-based framework for model selection while paying special attention to the interaction effect of models. In this framework, we introduce four ensemble techniques and compare them to the state-of-the-art in experiments on publicly available real-world data.