Multi-criteria Approach for Selection of Green and Grey Infrastructure to Reduce Flood Risk and Increase CO-benefits

Continuous changes in climate conditions combined with urban population growth pose cities as one of the most vulnerable areas to increasing flood risk. In such an atmosphere of growing uncertainty, a more effective flood risk management is becoming crucial. Nevertheless, decision-making and selection of adequate systems is a difficult task due to complex interactions between natural, social and built environments. The combination of green (or sustainable) and grey (or traditional) options has been proposed as a way forward to ensure resilience in advance of extreme events, and at the same time to obtain co-benefits for society and the environment. The present paper describes a novel method for selection of urban flood measures, based on a multi-criteria analysis that includes flood risk reduction, cost minimization and enhancement of co-benefits. The aim of this method is to assist decision makers in selecting and planning measures, which afterwards can be part of either high level scoping analysis or more complex studies, such as model based assessment. The proposed method is implemented within a tool which operates as a standalone application. Through this tool, the method has been applied in three study cases. The findings obtained indicate promising potential of the method here introduced.     

Effects of additives on densification, microstructure and properties of liquid-phase sintered silicon carbide

Dense SiC ceramics were obtained by hot pressing of -SiC powders using Al₂O₃-Y₂O₃ and La₂O₃-Y₂O₃ additive systems. The effect of the addition of an amount of ultrafine SiC to commercial silicon carbide powder was evaluated. Sintering behaviour and microstructure depended on type and amount of liquid phase, as densification proceeded via a classical solution-reprecipitation mechanism. A core/rim structure of SiC grains indicated that reprecipitation of a solid solution of SiC containing Al and O occurred on pure SiC nuclei. Grain boundary phase was constituted of crystalline YAG and amorphous silicates. Values of flexural strength up to 750 MPa at RT and up to 550 MPa at 1000 °C were measured. At 1300 °C a strong degradation of strength was attributed to softening of the amorphous portion of grain boundary phase. In highly dense materials toughness ranged from 2.95 to 3.17 MPa·m^1/2 and hardness from 21 to 23 GPa.     

Therapies for the Treatment of Cardiovascular Disease Associated with Type 2 Diabetes and Dyslipidemia

Cardiovascular disease (CVD) is the leading cause of death worldwide and is the clinical manifestation of the atherosclerosis. Elevated LDL-cholesterol levels are the first line of therapy but the increasing prevalence in type 2 diabetes mellitus (T2DM) has positioned the cardiometabolic risk as the most relevant parameter for treatment. Therefore, the control of this risk, characterized by dyslipidemia, hypertension, obesity, and insulin resistance, has become a major goal in many experimental and clinical studies in the context of CVD. In the present review, we summarized experimental studies and clinical trials of recent anti-diabetic and lipid-lowering therapies targeted to reduce CVD. Specifically, incretin-based therapies, sodium-glucose co-transporter 2 inhibitors, and proprotein convertase subtilisin kexin 9 inactivating therapies are described. Moreover, the novel molecular mechanisms explaining the CVD protection of the drugs reviewed here indicate major effects on vascular cells, inflammatory cells, and cardiomyocytes, beyond their expected anti-diabetic and lipid-lowering control. The revealed key mechanism is a prevention of acute cardiovascular events by restraining atherosclerosis at early stages, with decreased leukocyte adhesion, recruitment, and foam cell formation, and increased plaque stability and diminished necrotic core in advanced plaques. These emergent cardiometabolic therapies have a promising future to reduce CVD burden.