Control of stroma-dependent hematopoiesis by basic fibroblast growth factor: stromal phenotypic plasticity and modified myelopoietic functions

The immunological agglutination reactions of physically absorbed F(ab')2 molecules onto anionic and cationic latex particles have been investigated by means of optical absorbance measurements. These measurements have been conducted under different conditions to determine the most influential factors. Surface F(ab')2 and BSA densities, particle concentration in the reaction medium and polyethylene glycol concentration are some of these factors. Sensitized cationic and anionic latexes differ considerably with respect to their colloidal stability and reactivity. As a general rule, the sensitized cationic latex has a relatively higher colloidal stability and hence, it provides reagents with a better optical response. Less than 0.025 microgram/ml of C-reactive protein has been detected using this particle enhanced optical immunoassay.     

Towards a contingent approach of customer involvement in defence projects: An exploratory study

This paper reports the main results of an exploratory, multiple case study investigating customer involvement practices in system development projects in the Israeli defence industry. The study proposes and examines a theoretical contingency model regarding the effect of customer involvement modes on project success, moderated by project characteristics. It focuses specifically on the working mode of customers' representatives along the continuum between external supervision to full participation in project activities.     

Effect of nanofillers and production methods to control the interfacial characteristics of glass bundles in textile fabric cement-based composites

The objective of this study was to control the free areas within AR glass strands to induce controlled telescopic bonding during the service life of textile fabric cement-based composite using organic (polymers) and inorganic (pozzolanic) nanoparticles (fillers) with two particle sizes and glass transition temperatures. Wet (one step) and dry (two-step) production methodologies were used to prepare the composites. Their tensile behavior after two aging periods was studied and supported with microstructure observations. It was found that composite properties were strongly influenced by adding filler particles to the glass bundle and that the magnitude and efficiency of the modification was highly dependent on filler particle type, structure, and production method. The best initial mechanical performances and durability were obtained with large particle silica fume filler (200 nm) for both production methods.     

“Collapsible” lightweight aggregate concrete. Part II: characterization under static and dynamic loadings

In this work a granular cementitious composite has been developed, tailoring its performance to a low compressive strength and high deformation and energy dissipation capacity, which can be required to the material when employed in post-installed screeds for protection of structures and infrastructures against accidental actions such as impact and blast. The required level of performance can be achieved by uniform grain size distribution, paste content as low as minimum theoretical void ratio and low paste strength: it is believed that the synergy between the aforementioned three requirements can allow for energy dissipation capacity after paste cracking due to both rearrangement of grain meso-structure and, in case, grain crushing. After the mix design concept and optimization of the material composition, illustrated in the first part of this companion paper study, the mechanical performance of the composite under static and impact compressive loadings has been thoroughly characterized, as affected by mix-design variables, such as paste volume fraction, water to cement ratio and aggregate size. The reliability will thus be thoroughly checked, of the employed material concept, and the influence will also be investigated, if any, of specimen shape, size and boundary conditions.     

Analysis of the impedance spectra of short conductive fiber-reinforced composites

The presence of small amounts of short conductive fibers in a composite of finite matrix conductivity results in the subdivision of the one matrix impedance arc into two separate low and high frequency arcs in the complex impedance plane. These features are attributable to a frequency-switchable interfacial impedance on the fiber surfaces, rendering them insulating at DC and low AC frequencies, but conducting at intermediate frequencies. A combination of physical simulations (single wires in tap water) and pixel-based computer modeling was employed to investigate the roles of fiber pull-out, debonding, and orientation on the impedance response of fiber-reinforced composites. The ratio of the low frequency arc size to the overall DC resistance (-parameter) is sensitive to pull-out and/or debonding, especially when a fiber just barely makes contact with the matrix. The -parameter is also quite sensitive to fiber orientation with respect to the direction of the applied field. Ramifications for the characterization of cement, ceramic, and polymer matrix composites are discussed.     

Gram-negative enteric bacteremia in children in the Negev (1989-1994)

During 1989-1994, there were 322 episodes of Gram-negative enteric bacteremia in 308 children. The incidence increased from 31/100,000 in children younger than 15 years of age during 1989-1991, to 50/100,000 during 1992-1994. The most common pathogens were Klebsiella, E. Coli, Salmonella and Enterobacter. 39% of episodes were nosocomial and a significant increase was recorded for each species during the last 3 years of the study. Klebsiella represented the most common pathogen causing nosocomial bacteremia, while E. coli and Salmonella were the main pathogens causing community-acquired bacteremia. In this study in southern Israel, the incidence of Gram-negative enteric bacteremia was significantly higher in Bedouin children, with the exception of bacteremia due to Salmonella, which occurred mainly in Jewish children.     

Safety evaluation of flashing amber operation at signalized intersections

The safety of a flashing amber signal for all directions at off-peak hours as a replacement for regular traffic signal operations was evaluated. The proposed control strategy was motivated by the need for energy conservation through reduced amounts of acceleration and of idling time of vehicles. The methodology of the study employed as a measure a broadened definition of "conflict" that freed observers from the need to detect only emergency evasive manoeuvres and decreased their subjective interpretations. Observations were carried out by trained observers at a sample of intersections, using two control strategies: full signal operation and flashing amber phase. Stationed at each leg of an intersection, the observers noted the travel direction of any two vehicles involved in a conflict. The results showed that the most frequent type of conflict under full signal operation was of the rear-end type; during the flashing amber operation, crossing and merging conflicts were dominant. It was concluded that up to a volume of 600 vehicles per hour, flashing operation does not increase the number of conflicts.     

Lymphomagenesis in AKR.Fv-1b congenic mice

In the AKR.Fv-1b congenic strain the Fv-1n allele of the AKR/J mice was substituted with the Fv-1b allele, thereby limiting viral replication and spread of the endogenous N-tropic murine leukemia virus. As a result of this genetic change AKR.Fv-1b mice develop a low spontaneous incidence (7%) of T-cell lymphomas and about 28% of Ly-1+ B-cell lymphomas are observed in old mice. Characteristic changes in thymus subpopulations of AKR/J mice (related to the formation of the dual tropic mink cell focus inducing (MCF) type virus in the thymus) were not observed in the thymus of AKR.Fv-1b mice. In contrast to the low susceptibility to spontaneous T-cell lymphoma development, these mice were highly sensitive to fractionated irradiation or to radiation leukemia virus (a mixture of N- and B-tropic viruses) induced T-cell lymphoma. Potential lymphoma cells (that would ultimately develop into Ly-1+ B-cell lymphomas) were demonstrated in bone marrow and spleens of 16-24-month-old mice. Analysis of the Ly-1+ IgM+ B-cell population in spleens of 18-month-old mice revealed a significant increase in this population (35% versus 2% in young spleens). The spontaneous Ly-1+ B-cell lymphoma incidence could be enhanced (up to 77%) by in vivo administration of anti-CD8 monoclonal antibody or IL-4 to 18-month-old mice. Virological analysis of T/B-cell lymphomas for class I MCF viruses indicated that Class I MCF development was tightly correlated with T-lymphoma development (except radiation induced tumors that showed no MCF provirus involvement). In contrast, Ly-1+ B-cell lymphoma development was independent of Class I MCF pathogenic virus involvement.     

A search for a single-ion-conducting polymer electrolyte: Combined effect of anion trap and inorganic filler

Lithium trifluoromethanesulfonate:polyethylene oxide (PEO) polymer electrolytes modified by 1,1,3,3,5,5-meso-hexaphenyl-2,2,4,4,6,6-meso-hexamethyl-6-pyrrole (C6P) and nanosize silica filler were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and electrochemical means. An increase in the lithium transference number is observed upon incorporation of even a small amount of C6P. Silica facilitates interchain ion hopping in polymer electrolytes and possibly introduces an additional interfacial ion-conduction path without decreasing t₊. Stable solid electrolyte interphase resistance (SEI) was achieved in the polymer electrolytes containing calix[6]pyrrole and silica. It was found that lithium single-ion-conductive polymers with good electrochemical stability and ion transport properties have the potential for considerably boosting the performance of lithium/molybdenum oxysulfide all-solid-state thin film batteries.