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41.
P Brown L Cervenáková L McShane LG Goldfarb K Bishop F Bastian J Kirkpatrick P Piccardo B Ghetti DC Gajdusek 《Canadian Metallurgical Quarterly》1998,50(3):684-688
A 53-year-old man died of sporadic Creutzfeldt-Jakob disease (CJD) after a 1.5-year clinical course. Four and a half years later, his then 55-year-old widow died from CJD after a 1-month illness. Both patients had typical clinical and neuropathologic features of the disease, and pathognomonic proteinase-resistant amyloid protein ("prion" protein, or PrP) was present in both brains. Neither patient had a family history of neurologic disease, and molecular genetic analysis of their PrP genes was normal. No medical, surgical, or dietary antecedent of CJD was identified; therefore, we are left with the unanswerable alternatives of human-to-human transmission or the chance occurrence of sporadic CJD in a husband and wife. 相似文献
42.
Three projective personality tests were used to assess attitude to aggression (The Identification Test), anxiety and defenses (The Meta-Contrast Technique) and creative functioning (The Creative Functioning Test) in 70 patients with breast cancer. Discriminant analyses were applied pro primo to characterize psychologically patients with a better prognosis and patients with a poorer prognosis. A second aim was to characterize psychologically older (postmenopausal) and younger (premenopausal) women. Generally, high scores on the Identification Test indicated maladaptive attitudes towards aggression among all the patients. Patients with a poorer prognosis showed responses that in healthy subjects indicate acknowledgement of aggressive impulses, perhaps suggesting lack of "defenses" against such impulses among those patients. Another way to describe it would be that patients with a better prognosis seem to have (normally nonadaptive) "defenses" against aggressive impulses while those with poorer prognosis have not. Surprisingly, the patients with a better prognosis (but not those with a poorer prognosis) gave responses classified as depression in the Meta-Contrast Technique. Typical of premenopausal patients were responses classified as anxiety as well as reaction formation on the Identification Test. Responses classified as adaptive defenses (isolation) were seen in the Meta-Contrast Technique. A surprising finding was that many of these patients were characterized by high scores on the creativity test. These original statistically significant findings of attitudes towards aggression and creative functioning in breast cancer patients are discussed in relation to the underlying nature of aggression and creativity. 相似文献
43.
44.
Luís Miguel Alves Fernandes Gonçalo Cruz Matos Diogo Azevedo Ricardo Rodrigues Nunes Hugo Paredes Leonel Morgado 《Behaviour & Information Technology》2016,35(11):907-918
ABSTRACTGestural interaction devices emerged and originated various studies on multimodal human–computer interaction to improve user experience (UX). However, there is a knowledge gap regarding the use of these devices to enhance learning. We present an exploratory study which analysed the UX with a multimodal immersive videogame prototype, based on a Portuguese historical/cultural episode. Evaluation tests took place in high school environments and public videogaming events. Two users would be present simultaneously in the same virtual reality (VR) environment: one as the helmsman aboard Vasco da Gama’s fifteenth-century Portuguese ship and the other as the mythical Adamastor stone giant at the Cape of Good Hope. The helmsman player wore a VR headset to explore the environment, whereas the giant player used body motion to control the giant, and observed results on a screen, with no headset. This allowed a preliminary characterisation of UX, identifying challenges and potential use of these devices in multi-user virtual learning contexts. We also discuss the combined use of such devices, towards future development of similar systems, and its implications on learning improvement through multimodal human–computer interaction. 相似文献
45.
On the elastic modulus degradation in continuum damage mechanics 总被引:6,自引:0,他引:6
To measure accurately the elastic modulus of a metal, E, can be a difficult task when a specimen undergoes plastic strains. Moreover, some failure criteria, such as those associated with Continuum Damage Mechanics, require the change of elastic modulus with strain to define a measure of damage, D, in a material or structure. Thus, it is important to assess the possible geometrical influence of a specimen on the measurement of the elastic modulus at different deformation levels. It is shown in this article, with the aid of a numerical simulation, that any plastic strains induce important geometrical effects in the evaluation of E, which have a significant influence on the evaluation of the scalar damage parameter, D. 相似文献
46.
Simulations of extensional flow in microrheometric devices 总被引:1,自引:0,他引:1
Mónica S. N. Oliveira Lucy E. Rodd Gareth H. McKinley Manuel A. Alves 《Microfluidics and nanofluidics》2008,5(6):809-826
We present a detailed numerical study of the flow of a Newtonian fluid through microrheometric devices featuring a sudden
contraction–expansion. This flow configuration is typically used to generate extensional deformations and high strain rates.
The excess pressure drop resulting from the converging and diverging flow is an important dynamic measure to quantify if the
device is intended to be used as a microfluidic extensional rheometer. To explore this idea, we examine the effect of the
contraction length, aspect ratio and Reynolds number on the flow kinematics and resulting pressure field. Analysis of the
computed velocity and pressure fields show that, for typical experimental conditions used in microfluidic devices, the steady
flow is highly three-dimensional with open spiraling vortical structures in the stagnant corner regions. The numerical simulations
of the local kinematics and global pressure drop are in good agreement with experimental results. The device aspect ratio
is shown to have a strong impact on the flow and consequently on the excess pressure drop, which is quantified in terms of
the dimensionless Couette and Bagley correction factors. We suggest an approach for calculating the Bagley correction which
may be especially appropriate for planar microchannels.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
47.
IA Andriashvili RSh Adamiia LI Kvachadze TG Melitauri LG Pataridze 《Canadian Metallurgical Quarterly》1977,42(2):300-305
The composition of nitrous bases of phage FI-1 DNA was studied. As is evidenced from the values of buoyant density in CsCl (p=1,7093 g/cm(3)), melting temperature (T degrees m=86,05 degrees), spectral parameters and direct chromatographic determination, the DNA analysed contains 41,5 mole% pairs of guanine-cystosine. 5-hydroxymethylcytosine and other anomalous bases were not found. Chemical identification and jaxtposition of data of buoyant density in CsCl and Cs2SO4 (p=1,4466 g/cm(3)) and T degrees m. showed the presence of the extra-sugar component in DNA, most likely in the form of hentibiose. Spectral character of thermal denaturation of DNA in different solvents is indicative of the double helixity of its structure. DNA is characterized by enthalpies of conformational transitions "helix coil" (deltaH=12,3 kcal/g) and (deltaH=10 kcal/g) for the solvents, 1 x SSC, and 0,1 x SSC, correspondingly. The presence of extra-sugar in DNA with standard set of nitrous bases is discussed. 相似文献
48.
The trial record in an antitrust case against the Oregon State Medical Society, finally decided in 1952, was examined to reconstruct the behavior of a competitive market for health insurance coverage. Health insurers, called "hospital associations," were found to have engaged individually in cost-control efforts similar to, but possibly more aggressive than, today's utilization review under professional sponsorship. The subsequent disappearance of these insurer-initiated cost controls in Oregon is traced to the medical society's organization of a competing Blue Shield plan as a model of insurer conduct and to a simultaneous boycott by physicians of the hospital associations as long as they persisted in questioning doctors' practices. Some modern parallels are noted, and the advantages of fostering privately sponsored cost-control efforts are suggested. 相似文献
49.
LG Kupchinski? IuA Barshte?n BG Pogodaev AI Treshinski? 《Canadian Metallurgical Quarterly》1976,(3):80-84
A study was made of a possibility of using Soviet made membranes "Vladipor" with a pore diameter of 16--17 nm for the purpose of concentration and purification of antigenic extracts from stab cultures of S. typhi obtained by the action of typsin, hydrogen peroxide and detergents. Preparations, complete by antigenic structure, were obtained by ultrafiltration, with a good yield. The maximal rate of ultrafiltration was noted in case of "peroxide" antigenic preparations. The use of diafiltration provided a significant reduction of the ash content in the end products. 相似文献
50.
Raman spectroscopy has been used as a local probe to characterize the structural evolution of magnetron-sputtered decorative zirconium oxynitride ZrOxNy films which result from an increase of reactive gas flow in the deposition. The lines shapes, the frequency position and widths of the Raman bands show a systematic change as a function of the reactive gas flow (a mixture of both oxygen and nitrogen). The as-deposited zirconium nitride film presents a Raman spectrum with the typical broadened bands, due to the disorder induced by N vacancies. The recorded Raman spectrum of the zirconium oxide film is typical of the monoclinic phase of ZrO2, which is revealed also by X-ray diffraction. Raman spectra of zirconium oxynitride thin films present changes, which are found to be closely related with the oxygen content in films and the subsequent structural changes. 相似文献