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61.
62.
Osama Abudayyeh Amber Dibert-DeYoung Edward Jaselskis 《Canadian Metallurgical Quarterly》2004,130(3):433-439
This paper provides a historical perspective on construction research trends as reflected in the American Society of Civil Engineer’s Journal of Construction Engineering and Management (JCEM). The paper reports the results of an 18-year analysis of JCEM between 1985 and 2002. The analysis focused on such data as author information (affiliations and home countries), as well as the research topics of the technical papers. The paper summarizes the data extracted from the journal and use it to analyze construction research trends. Construction trends reveal that U.S. writers contributed the most papers by that there has been an increasing number of international submissions to the journal. The top research topical areas relate to scheduling, productivity, constructability, simulation, cost control, planning, safety, and computer systems as described in this paper show that research is increasing throughout the world and topics are changing as current needs change. However, there is a need to increase research collaboration between industry and academia, government and academia, and industry and government to advance the construction industry. 相似文献
63.
James D. West Eric D. Austin Elise M. Rizzi Ling Yan Harikrishna Tanjore Amber L. Crabtree Christy S. Moore Gladson Muthian Erica J. Carrier David A. Jacobson Rizwan Hamid Peggy L. Kendall Susan Majka Anandharajan Rathinasabapathy 《International journal of molecular sciences》2021,22(9)
Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary arterial hypertension (PAH). KCNK3 is expressed in several cell and tissue types on both membrane and endoplasmic reticulum and potentially plays a role in multiple pathological process associated with PAH. However, the role of various stressors driving the susceptibility of KCNK3 mutation to PAH is unknown. Hence, we exposed kcnk3fl/fl animals to hypoxia, metabolic diet and low dose lipopolysaccharide (LPS) and performed molecular characterization of their tissue. We also used tissue samples from KCNK3 patients (skin fibroblast derived inducible pluripotent stem cells, blood, lungs, peripheral blood mononuclear cells) and performed microarray, immunohistochemistry (IHC) and mass cytometry time of flight (CyTOF) experiments. Although a hypoxic insult did not alter vascular tone in kcnk3fl/fl mice, RNASeq study of these lungs implied that inflammatory and metabolic factors were altered, and the follow-up diet study demonstrated a dysregulation of bone marrow cells in kcnk3fl/fl mice. Finally, a low dose LPS study clearly showed that inflammation could be a possible second hit driving PAH in kcnk3fl/fl mice. Multiplex, IHC and CyTOF immunophenotyping studies on human samples confirmed the mouse data and strongly indicated that cell mediated, and innate immune responses may drive PAH susceptibility in these patients. In conclusion, loss of function KCNK3 mutation alters various physiological processes from vascular tone to metabolic diet through inflammation. Our data suggests that altered circulating immune cells may drive PAH susceptibility in patients with KCNK3 mutation. 相似文献
64.
A.Andr Berthiaume Todd Bittner Ljubomir Perkovi Amber Settle Janos Simon 《Theoretical computer science》2004,320(2-3):213-228
In this paper we improve the upper and lower bounds on the complexity of solutions to the firing synchronization problem on a ring. In this variant of the firing synchronization problem the goal is to synchronize a ring of identical finite automata. Initially, all automata are in the same state except for one automaton that is designated as the initiator for the synchronization. The goal is to define the set of states and the transition function for the automata so that all machines enter a special fire state for the first time and simultaneously during the final round of the computation. In our work we present two solutions to the ring firing synchronization problem, an 8-state minimal-time solution and a 6-state non-minimal-time solution. Both solutions use fewer states than the previous best-known minimal-time automaton, a 16-state solution due to Culik. We also give the first lower bounds on the number of states needed for solutions to the ring firing synchronization problem. We show that there is no 3-state solution and no 4-state, symmetric, minimal-time solution for the ring. 相似文献
65.
Employing subgroup evolution for irregular-shape nesting 总被引:2,自引:0,他引:2
This paper introduces a new method to solve the irregular-shape, full-rotation nesting problem by a genetic algorithm. Layout patterns are evolved in hierarchical subgroups to facilitate the search for an optimal solution in such a complex solution space. The genotype used in the genetic algorithm contains both the sequence and rotation for each shape, requiring new genetic operators to manipulate a multi-type genetic representation. A lower-left placement heuristic coupled with matrix encoding of the shapes and plate prevents overlap and constrains the solution space to valid solutions. This new method is able to efficiently search the solution space for large problems involving complex shapes with 360 degrees of freedom. The algorithm generates better solutions than previously published evolutionary methods. 相似文献
66.
Emilie Logie Claudina Perez Novo Amber Driesen Pieter Van Vlierberghe Wim Vanden Berghe 《International journal of molecular sciences》2021,22(23)
Through phosphorylation of their substrate proteins, protein kinases are crucial for transducing cellular signals and orchestrating biological processes, including cell death and survival. Recent studies have revealed that kinases are involved in ferroptosis, an iron-dependent mode of cell death associated with toxic lipid peroxidation. Given that ferroptosis is being explored as an alternative strategy to eliminate apoptosis-resistant tumor cells, further characterization of ferroptosis-dependent kinase changes might aid in identifying novel druggable targets for protein kinase inhibitors in the context of cancer treatment. To this end, we performed a phosphopeptidome based kinase activity profiling of glucocorticoid-resistant multiple myeloma cells treated with either the apoptosis inducer staurosporine (STS) or ferroptosis inducer RSL3 and compared their kinome activity signatures. Our data demonstrate that both cell death mechanisms inhibit the activity of kinases classified into the CMGC and AGC families, with STS showing a broader spectrum of serine/threonine kinase inhibition. In contrast, RSL3 targets a significant number of tyrosine kinases, including key players of the B-cell receptor signaling pathway. Remarkably, additional kinase profiling of the anti-cancer agent withaferin A revealed considerable overlap with ferroptosis and apoptosis kinome activity, explaining why withaferin A can induce mixed ferroptotic and apoptotic cell death features. Altogether, we show that apoptotic and ferroptotic cell death induce different kinase signaling changes and that kinome profiling might become a valid approach to identify cell death chemosensitization modalities of novel anti-cancer agents. 相似文献
67.
68.
Acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the acyl-CoA-dependent acylation of lysophosphatidylcholine
(LPC) to produce PC and CoA. LPCAT activity may affect the incorporation of fatty acyl moieties at the sn-2 position of PC where PUFA are formed and may indirectly influence seed TAG composition. LPCAT activity in microsomes prepared
from microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf) was assayed using [1-14C]acyl-CoA as the fatty acyl donor. LPCAT activity was optimal at neutral pH and 35°C, and was inhibited by 50% at a BSA concentration
of 3 mg mL−1. At acyl-CoA concentrations above 20 μM, LPCAT activity was more specific for oleoyl (18∶1)-CoA than stearoyl (18∶0)- and
palmitoyl (16∶0)-CoA. Lauroyl (12∶0)-CoA, however, was not an effective acyl donor. LPC species containing 12∶0, 16∶0, 18∶0,
or 18∶1 as the fatty acyl moiety all served as effective acyl acceptors for LPCAT, although 12∶0-LPC was somewhat less effective
as a substrate at lower concentrations. The failure of LPCAT to catalyze the incorporation of a 12∶0 moiety from acyl-CoA
into PC is consistent with the tendency of acyltransferases to discriminate against incorporation of this fatty acyl moiety
at the sn-2 position of TAG from the seed oil of transgenic B. napus expressing a medium-chain thioesterase. 相似文献
69.
Cynthia?A?DaleyEmail author Amber?Abbott Patrick?S?Doyle Glenn?A?Nader Stephanie?Larson 《Nutrition journal》2010,9(1):10
Growing consumer interest in grass-fed beef products has raised a number of questions with regard to the perceived differences
in nutritional quality between grass-fed and grain-fed cattle. Research spanning three decades suggests that grass-based diets
can significantly improve the fatty acid (FA) composition and antioxidant content of beef, albeit with variable impacts on
overall palatability. Grass-based diets have been shown to enhance total conjugated linoleic acid (CLA) (C18:2) isomers, trans vaccenic acid (TVA) (C18:1 t11), a precursor to CLA, and omega-3 (n-3) FAs on a g/g fat basis. While the overall concentration
of total SFAs is not different between feeding regimens, grass-finished beef tends toward a higher proportion of cholesterol
neutral stearic FA (C18:0), and less cholesterol-elevating SFAs such as myristic (C14:0) and palmitic (C16:0) FAs. Several
studies suggest that grass-based diets elevate precursors for Vitamin A and E, as well as cancer fighting antioxidants such
as glutathione (GT) and superoxide dismutase (SOD) activity as compared to grain-fed contemporaries. Fat conscious consumers
will also prefer the overall lower fat content of a grass-fed beef product. However, consumers should be aware that the differences
in FA content will also give grass-fed beef a distinct grass flavor and unique cooking qualities that should be considered
when making the transition from grain-fed beef. In addition, the fat from grass-finished beef may have a yellowish appearance
from the elevated carotenoid content (precursor to Vitamin A). It is also noted that grain-fed beef consumers may achieve
similar intakes of both n-3 and CLA through the consumption of higher fat grain-fed portions. 相似文献
70.
The demand for bottled water has grown tremendously in recent years, together with concern about its environmental impacts. The authors surveyed individuals in Phoenix, Arizona about their water consumption behaviour, socio-demographic characteristics, perception of water quality and trust in the government's willingness to respond to water quality issues. Using a logit model, the authors then tested the relationship between the respondents' characteristics and bottled water consumption for cooking and drinking in the home. Our results indicate that bottled water consumption reflects lifestyle choice not environmental concerns. 相似文献