Fault diagnosis and accommodation of nonlinear systems based on multiple-model adaptive unscented Kalman filter and switched MPC and H-infinity loop-shaping controller

In this paper, a new active fault tolerant control (AFTC) methodology is proposed based on a state estimation scheme for fault detection and identification (FDI) to deal with the potential problems due to possible fault scenarios. A bank of adaptive unscented Kalman filters (AUKFs) is used as a core of FDI module. The AUKF approach alleviates the inflexibility of the conventional UKF due to constant covariance set up, leading to probable divergence. A fuzzy-based decision making (FDM) algorithm is introduced to diagnose sensor and/or actuator faults. The proposed FDI approach is utilized to recursively correct the measurement vector and the model used for both state estimation and output prediction in a model predictive control (MPC) formulation. Robustness of the proposed FTC system, H_∞ optimal robust controller and MPC are combined via a fuzzy switch that is used for switching between MPC and robust controller such that FTC system is able to maintain the offset free behavior in the face of abrupt changes in model parameters and unmeasured disturbances. This methodology is applied on benchmark three-tank system; the proposed FTC approach facilitates recovery of the closed loop performance after the faults have been isolated leading to an offset free behavior in the presence of sensor/actuator faults that can be either abrupt or drift change in biases. Analysis of the simulation results reveals that the proposed approach provides an effective method for treating faults (biases/drifts in sensors/actuators, changes in model parameters and unmeasured disturbances) under the unified framework of robust fault tolerant control.     

Metal-electroceramic bonding in PZT through the selective application of laser energy

Ferrite powder has been directly bonded to the surface of poled lead zirconate titanate (PZT-4) using direct laser sintering. The resultant cohesion between the metal and ceramic is extremely good although care must be taken with the processing in order to limit the damage inflicted upon the PZT. Four point bending suggests that the strength of the processed samples has reduced to 60 MPa as compared to 76 MPa for the unprocessed ceramic. Electrical and piezoelectric measurements shows that the laser sintering had caused mechanical damage to a depth of 550 μm and thermal damage (depoling) to a depth of 800 μm.     

Circ_0011129 Encapsulated by the Small Extracellular Vesicles Derived from Human Stem Cells Ameliorate Skin Photoaging

Photoaging is not only the main cause of skin aging caused by exogenous factors, it is also related to a variety of skin diseases and even malignant tumors. Excessive and repeated exposure to ultraviolet radiation, especially UVA induces oxidative stress, DNA damage, inflammation, and collagen and elastin degeneration, ultimately leads to skin photoaging, manifested by skin redness, coarse wrinkles, and pigmentation even skin cancer. There has been a large demand of effective prevention and medications but approaches in the current management of photoaging are very limited. In the previous study, we found that a non-coding circular RNA circ_0011129 acts as a miR-6732-5p adsorption sponge to inhibit the reduction of type I collagen and the denaturation and accumulation of elastin in UVA-induced HDF cells photoaging model. However, in vivo instability and efficient delivery to the target cell of circRNA is a major challenge for its clinical application. Therefore, improving its stability and delivery efficiency are desired. In this study, we proposed a strategy of delivering circ_0011129 with small extracellular vesicles (sEVs) from human adipose-derived stem cells (hADSCs) to intervene in the photoaging process. The results showed that sEVs from hADSCs in 3D bioreactor culture (3D-sEVs) can prevent photoaging. Consequently, by overexpressing circ_0011129 in hADSCs, we successfully loaded it into 3D-sEVs (3D-circ-sEVs) and its protective effect was better. Our studies provide a novel approach to preventing skin photoaging, which has important clinical significance and application value for the development of non-coding RNA drugs to treat skin photoaging. We first screened out hADSCs-derived sEVs with excellent anti-oxidant effects. We then compared the sEVs collected from traditional 2D culture with 3D bioreactor culture. By miRNA-seq and GEO data analysis, we found that miRNAs in 3D-sEVs were enriched in cell activities related to apoptosis, cellular senescence, and inflammation. Subsequently, we prepared circ_0011129-loaded 3D-sEVs (3D-circ-sEVs) by overexpressing it in hADSCs for the treatment of photoaging in vitro. We proved that 3D-circ-sEVs can interfere with the process of cell photoaging and protect cells from UVA radiation damage, as well as in a H2O2-induced oxidative stress model.     

从欧美日标准看我国不锈钢钢管制造业的现状及发展前景(上)

介绍了欧、美、日不锈钢钢管标准的特点。详细对比欧、美、日不锈钢钢管新标准中钢种类别、制造方法、供货状态、规格范围等有关内容。指出我国不锈钢钢管制造业应在不断扩大产量的同时,加大新钢种研发力度,完善产品规格范围,开发不锈钢钢管制造新工艺,注重产品外观质量,增加我国不锈钢钢管行业的国际竞争力。     

Lie group method for solving viscous barotropic vorticity equation in ocean climate models

In studying the problem of the nonlinear viscous barotropic non-divergent vorticity equation on $f$- and $\beta$- planes, the method of Lie group has been applied. The method reduces the number of independent variables by one, and consequently, for the case of three independent variables we applied the method successively twice and the nonlinear partial differential equation reduces to ordinary differential equation. Investigation of exact solutions of the viscous barotropic non-divergent vorticity equation on $f$- and $\beta$- planes, via the application of Lie group, provides large classes of new exact solutions which include both Rossby and Rossby–Haurwitz waves as special cases. Also, The Lie symmetries of the viscous barotropic non-divergent vorticity equation with two parameters $F$ and $\beta$, are determined. The possible reductions of the viscous barotropic vorticity equation with two parameters $F$ and $\beta$ have been investigated by means of one- dimensional Lie subalgebras.     

面向学生的高校智能管理系统的设计与实现

随着网络技术的快速发展,高校对学生信息化的建设和管理愈加重视。高校智能管理系统是高校信息化建设的重要展现。本文针对学生日常的生活轨迹和生活信息,进行相关的数据分析和挖掘,采用Python语言和MySQL数据库技术,在Flask框架上进行改进,实现了以学习管理、健康管理和生活管理三大功能模块的轻量级Web和安卓应用,将面向学生的高校智能管理系统打造成一个集成化的平台,以提升校园管理的工作效率和提供健康安全保障。     

Manual Therapy Facilitates Homeostatic Adaptation to Bone Microstructural Declines Induced by a Rat Model of Repetitive Forceful Task

The effectiveness of manual therapy in reducing the catabolic effects of performing repetitive intensive force tasks on bones has not been reported. We examined if manual therapy could reduce radial bone microstructural declines in adult female Sprague–Dawley rats performing a 12-week high-repetition and high-force task, with or without simultaneous manual therapy to forelimbs. Additional rats were provided 6 weeks of rest after task cessation, with or without manual therapy. The control rats were untreated or received manual therapy for 12 weeks. The untreated TASK rats showed increased catabolic indices in the radius (decreased trabecular bone volume and numbers, increased osteoclasts in these trabeculae, and mid-diaphyseal cortical bone thinning) and increased serum CTX-1, TNF-α, and muscle macrophages. In contrast, the TASK rats receiving manual therapy showed increased radial bone anabolism (increased trabecular bone volume and osteoblast numbers, decreased osteoclast numbers, and increased mid-diaphyseal total area and periosteal perimeter) and increased serum TNF-α and muscle macrophages. Rest, with or without manual therapy, improved the trabecular thickness and mid-diaphyseal cortical bone attributes but not the mineral density. Thus, preventive manual therapy reduced the net radial bone catabolism by increasing osteogenesis, while rest, with or without manual therapy, was less effective.     

调容铁心串联电抗器的原理与性能分析

针对传统的电容器无功补偿装置存在补偿容量不灵活的缺点,提出解决问题的方法是采用调容串联电抗器以实现分级补偿。通过分析电容器无功补偿装置对串联电抗器的参数要求,对调容铁心串联电抗器的工作原理及设计要点作了介绍;对无功补偿方案进行对比,说明采用调容铁心串联电抗器后收到的有益效果。     

Enhancing the design and performance of a gate-all-around (GAA) charge plasma nanowire field-effect transistor with the help of the negative-capacitance technique

A gate-all-around charge plasma nanowire field-effect transistor (GAA CP NW FET) device using the negative-capacitance technique is introduced, termed the GAA CP NW negative-capacitance (NC) FET. In the face of bottleneck issues in nanoscale devices such as rising power dissipation, new techniques must be introduced into FET structures to overcome their major limitations. Negative capacitance is an efficient effect that can be incorporated into a device to enhance its performance for low-power applications and help to reduce the operating voltage. The Landau–Khalatnikov equation can be applied in such cases to obtain the effective bias. To determine the effects of negative capacitance, lead zirconate titanate (PZT) ferroelectric material, a ceramic material with perovskite properties, is adopted as a gate insulator. This approach diminishes the supply voltage and reduces the power dissipation in the device. Excluding their polarization properties, ferroelectric materials are similar to dielectric materials, and PZT offers abundant polarization with improved reliability and a higher dielectric capacitance. Without proper tuning of the thickness of the PZT material, hysteresis behavior mat occur. Hence, the thickness of the PZT material (t_FE) is an essential parameter to optimize the device performance and achieve a reduced threshold voltage for the GAA CP NW NC-FET device proposed herein. Furthermore, varying the thickness of the PZT ferroelectric material can also enhance the performance. When using the highest values of t_FE, improved outcomes with an analogously lower operating voltage are observed. The effects of varying t_FE on the performance characteristics of the device including the drain current, transconductance, polarized charge, etc. are also interpreted herein.