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101.
In this article, an analytical study of elastic P- and SV-wave scattering by a circular nanofiber is presented. The nanofiber is assumed to be surrounded by an inhomogeneous interphase layer, and Gurtin–Murdoch's model of surface elasticity is utilized to study the surface/interface effects in the regions between the fiber and interphase and also interphase and matrix. The simultaneous effects of surface elasticity and interphase inhomogeneity are considered here; by taking the inhomogeneous interphase to be composed of several sublayers, a transfer matrix approach is used to find the unknown field variables and, consequently, the scattering cross sections. The results indicate that considering the effects of surface elasticity and interphase inhomogeneity has a considerable impact on the calculated scattering cross sections.  相似文献   
102.
Elevated proinflammatory cytokines have been attributed to poor sleep quality in patients receiving hemodialysis. This is the first investigation about the relationship between sleep quality and circulating levels of antiinflammatory markers in these patients. A total of 72 patients who were receiving maintenance hemodialysis were enrolled in this cross‐sectional study. The Pittsburgh Sleep Quality Index (PSQI) was used to measure sleep quality. Patients were divided into two groups: good sleepers (PSQI score < 5) and poor sleepers (PSQI score ≥ 5). Assessments were made for serum biochemical parameters (albumin, parathyroid hormone), inflammatory (interleukin [IL]‐6, tumor necrosis factor‐alpha [TNF‐α], and high‐sensitivity c‐reactive protein [hs‐CRP] ) and antiinflammatory (IL‐10) markers. Fifty‐four patients (75%) were classified as poor sleepers. Poor sleepers showed significantly lower levels of serum IL‐10 and higher serum triglyceride and parathyroid hormone concentrations. These patients were more likely to have more comorbidities. The global PSQI score was significantly correlated with serum IL‐10 (p = 0.03) and triglyceride levels (p = 0.01). Multivariate logistic regression analysis showed a direct correlation between PSQI and having comorbidities (p = 0.011, odds ratio [OR] = 3.918; confidence interval 95% [CI] = 2.742–19.031), between PSQI and serum triglyceride (p = 0.027, OR = 1.027 [95% CI = 1.007–1.048] ), and an inverse correlation between PSQI and serum IL‐10 level (p = 0.021, OR = 0.424 [95% CI = 0.195–0.922]). Reduced circulating levels of the antiinflammatory cytokine IL‐10 were significantly associated with poor sleep quality in hemodialysis patients. Factors including serum IL‐10 and triglyceride concentrations and having comorbidities may predict patients prone to poor sleep quality.  相似文献   
103.
In Marrakech, solid by-products from tanneries are highly polluting, generating large amounts of nitrogenous and organic matter. In the present study composting is tested as a cost-effective method for waste management to overcome many of the environmental hazards and produce a stable, rich material for soil fertilization. Two composting trials were conducted after neutralization by ammonia or lime. The aim of the neutralization was to avoid the antimicrobial effects of the acidity in the tannery waste, thus ensuring correct composting. Different techniques such as elemental analysis and 13C NMR spectroscopy were applied to analyse humic acids isolated from raw and composted materials, and to monitor the process of tannery waste composting, and the stability and maturity of the final product according to the means of neutralization. Comparison of data showed similar behaviour in both trials, but the composting process appeared to be more complete following neutralization with lime. The C, H and N content decreased, while the O increased. The FTIR and 13C NMR spectra show the decrease of aliphatic compounds demonstrated by the reduction of absorbance around 2922 cm−1 and of the resonance in the C-alkyl area around 0–55 ppm. The humic acids newly formed during composting were richer in the O–N alkyl and oxidized aromatic structures that increased almost twofold on composting after neutralization with lime. The first principal component axis PC1 (54%) separated C-aliphatic, C-carboxylic and other less stable and less polycondensed compounds such as polyphenols from the more polycondensed O–N alkyl and oxidized C-aromatic compounds.  相似文献   
104.
Protein–protein interactions (PPIs) play a fundamental role in various biological functions; thus, detecting PPI sites is essential for understanding diseases and developing new drugs. PPI prediction is of particular relevance for the development of drugs employing targeted protein degradation, as their efficacy relies on the formation of a stable ternary complex involving two proteins. However, experimental methods to detect PPI sites are both costly and time-intensive. In recent years, machine learning-based methods have been developed as screening tools. While they are computationally more efficient than traditional docking methods and thus allow rapid execution, these tools have so far primarily been based on sequence information, and they are therefore limited in their ability to address spatial requirements. In addition, they have to date not been applied to targeted protein degradation. Here, we present a new deep learning architecture based on the concept of graph representation learning that can predict interaction sites and interactions of proteins based on their surface representations. We demonstrate that our model reaches state-of-the-art performance using AUROC scores on the established MaSIF dataset. We furthermore introduce a new dataset with more diverse protein interactions and show that our model generalizes well to this new data. These generalization capabilities allow our model to predict the PPIs relevant for targeted protein degradation, which we show by demonstrating the high accuracy of our model for PPI prediction on the available ternary complex data. Our results suggest that PPI prediction models can be a valuable tool for screening protein pairs while developing new drugs for targeted protein degradation.  相似文献   
105.
The increasing demand on execution of large-scale Cloud workflow applications which need a robust and elastic computing infrastructure usually lead to the use of high-performance Grid computing clusters. As the owners of Cloud applications expect to fulfill the requested Quality of Services (QoS) by the Grid environment, an adaptive scheduling mechanism is needed which enables to distribute a large number of related tasks with different computational and communication demands on multi-cluster Grid computing environments. Addressing the problem of scheduling large-scale Cloud workflow applications onto multi-cluster Grid environment regarding the QoS constraints declared by application’s owner is the main contribution of this paper. Heterogeneity of resource types (service type) is one of the most important issues which significantly affect workflow scheduling in Grid environment. On the other hand, a Cloud application workflow is usually consisting of different tasks with the need for different resource types to complete which we call it heterogeneity in workflow. The main idea which forms the soul of all the algorithms and techniques introduced in this paper is to match the heterogeneity in Cloud application’s workflow to the heterogeneity in Grid clusters. To obtain this objective a new bi-level advanced reservation strategy is introduced, which is based upon the idea of first performing global scheduling and then conducting local scheduling. Global-scheduling is responsible to dynamically partition the received DAG into multiple sub-workflows that is realized by two collaborating algorithms: (1) The Critical Path Extraction algorithm (CPE) which proposes a new dynamic task overall critically value strategy based on DAG’s specification and requested resource type QoS status to determine the criticality of each task; and (2) The DAG Partitioning algorithm (DAGP) which introduces a novel dynamic score-based approach to extract sub-workflows based on critical paths by using a new Fuzzy Qualitative Value Calculation System to evaluate the environment. Local-scheduling is responsible for scheduling tasks on suitable resources by utilizing a new Multi-Criteria Advance Reservation algorithm (MCAR) which simultaneously meets high reliability and QoS expectations for scheduling distributed Cloud-base applications. We used the simulation to evaluate the performance of the proposed mechanism in comparison with four well-known approaches. The results show that the proposed algorithm outperforms other approaches in different QoS related terms.  相似文献   
106.
Russian Journal of Nondestructive Testing - The location of reinforcement bar in concrete, the bar corrosion, diameter and the depth below the surface are important factors in the evaluation of the...  相似文献   
107.
In this work, the effects of three ionic liquids (ILs), namely, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium dicyanamide and tetraethyl-ammonium chloride, on methane hydrate formation and dissociation kinetic parameters were studied. The kinetic parameters including the initial rate of hydrate formation, hydrate stability at atmospheric pressure and hydrate storage capacity were evaluated. The experimental measurements were performed in an initial pressure range of 3.5–7.1 MPa. It was found that both of ILs with imidazolium-based cation increase the initial methane hydrate formation rate while the IL with ammonium-based cation leads to a decrease in the initial methane hydrate formation rate. It was also interpreted from the results that all of the three studied ILs decrease methane hydrate stability at atmospheric pressure and increase methane hydrate storage capacity. Finally, both of ILs with imidazolium-based cations were found to have higher impacts on decreasing hydrate stability at atmospheric pressure and increasing the methane hydrate storage capacity than the applied IL with ammonium-based cation.  相似文献   
108.
Motion estimation is one of the critical parts in video compression standards with a high computational load. Many motion estimation algorithms have been developed to reduce the number of search points compared to a full-search algorithm without losing the quality considerably. Most of them use fixed search patterns in their first step which may suffer from trapping into local minima or searching unnecessary blocks due to inappropriate size and type of search patterns. In this paper, a new dynamic search pattern using motion vectors of spatial and temporal neighboring blocks is proposed. The motion vectors of neighboring blocks are prioritized, in order to efficiently use of halfway stop technique. The simulation results indicate that proposed algorithm is very close to the full-search algorithm in quality, compared to other rivals. Moreover, the average number of searches is often less than other algorithms.  相似文献   
109.
A graphene oxide (GO) film is functionalized with metal (Au) and metal‐oxide (MoOx) nanoparticles (NPs) as a hole‐extraction layer for high‐performance inverted planar‐heterojunction perovskite solar cells (PSCs). These NPs can increase the work function of GO, which is confirmed with X‐ray photoelectron spectra, Kelvin probe force microscopy, and ultraviolet photoelectron spectra measurements. The down‐shifts of work functions lead to a decreased level of potential energy and hence increased Voc of the PSC devices. Although the GO‐AuNP film shows rapid hole extraction and increased Voc, a Jsc improvement is not observed because of localization of the extracted holes inside the AuNP that leads to rapid charge recombination, which is confirmed with transient photoelectric measurements. The power conversion efficiency (PCE) of the GO‐AuNP device attains 14.6%, which is comparable with that of the GO‐based device (14.4%). In contrast, the rapid hole extraction from perovskite to the GO‐MoOx layer does not cause trapping of holes and delocalization of holes in the GO film accelerates rapid charge transfer to the indium tin oxide substrate; charge recombination in the perovskite/GO‐MoOx interface is hence significantly retarded. The GO‐MoOx device consequently shows significantly enhanced Voc and Jsc, for which its device performance attains PCE of 16.7% with great reproducibility and enduring stability.  相似文献   
110.
Magnetic resonance imaging (MRI) is a highly advanced and sophisticated imaging modality for cardiac motion tracking and analysis, capable of providing 3D analysis of global and regional cardiac function with great accuracy and reproducibility. In the past few years, numerous efforts have been devoted to cardiac motion recovery and deformation analysis from MR image sequences. Many approaches have been proposed for tracking cardiac motion and for computing deformation parameters and mechanical properties of the heart from a variety of cardiac MR imaging techniques. In this paper, an updated and critical review of cardiac motion tracking methods including major references and those proposed in the past ten years is provided. The MR imaging and analysis techniques surveyed are based on cine MRI, tagged MRI, phase contrast MRI, DENSE, and SENC. This paper can serve as a tutorial for new researchers entering the field.  相似文献   
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