Formulation and pharmacokinetics of gelucire solid dispersions of flurbiprofen

Context: Development of solid dispersions is to improve the therapeutic efficacy by increasing the drug solubility, dissolution rate, bioavailability as well as to attain rapid onset of action.

Objective: The present research deals with the development of solid dispersions of flurbiprofen which is poorly water soluble to improve the solubility and dissolution rate using gelucires.

Materials and methods: In this study, solid dispersions were prepared following solvent evaporation method using gelucire 44/14 and gelucire 50/13 as carriers in different ratios. Then the formulations were evaluated for different physical parameters, solubility studies, DSC, FTIR studies and in vitro dissolution studies to select the best formulation that shows rapid dissolution rate and finally subjected to pharmacokinetic studies.

Results and discussion: From the in vitro dissolution study, formulation F3 showed the better improvement in solubility and dissolution rate. From the pharmacokinetic evaluation, the control tablets produced peak plasma concentration (C_max) of 9140.84?±?614.36?ng/ml at 3?h T_max and solid dispersion tablets showed C_max?=?11?445.46?±?149.23?ng/ml at 2?h T_max. The area under the curve for the control and solid dispersion tablets was 31?495.16?±?619.92 and 43?126.52?±?688.89?ng h/ml and the mean resident time was 3.99 and 3.68?h, respectively.

Conclusion: From the above results, it is concluded that the formulation of gelucire 44/14 solid dispersions is able to improve the solubility, dissolution rate as well as the absorption rate of flurbiprofen than pure form of drug.     

Experimental and simulation study of magnetorheological miniature gear-profile polishing (MRMGPP) method using flow restrictor

Journal of Mechanical Science and Technology - In this article, a new flow restrictor is utilized in the magnetorheological miniature gear-profile polishing (MRMGPP) method to ensure a consistent...     

Survey on communication architectures for wind energy integration with the smart grid

Communication systems are needed to integrate generated power from wind farms with the electrical grid. This paper provides a comprehensive review of available communication technologies, protocols and objectives related to wind energy and electrical grid integration. This paper summarizes the communication system solutions for wind generation. A major obstacle is an absence of unified communication architectures and standards.     

Diurnal and seasonal variabilities in surface ozone and its precursor gases at a semi‐arid site Anantapur (14.62°N, 77.65°E, 331 m asl) in India

Measurements of surface ozone and its precursor gases (NO_x and CO) have been made at a semi‐arid site Anantapur (14.62°N, 77.65°E, 331 m asl) in tropical Indian region for the period, 2001–2003. NO_x and CO levels were the highest during morning and late night hours at this site. Diurnal variations of ozone concentrations varied from 25 ppbv to 50 ppbv and were observed to increase gradually after sunrise, attaining a maximum value by the evening and decreasing gradually thereafter. During monsoon months, the diurnal amplitude of ozone was found to be small (20–25 ppbv). Seasonal variation in ozone showed a pronounced maximum (40–50 ppbv) in the winter and summer. Local pollutants were major contributors to the ozone levels during this period. Ozone shows a yearly mean mixing ratio of about 35.9 ± 8.8 ppbv. The daytime concentration of CO and NO_x varied between 200 to 1200 ppbv and 3 to 20 ppbv respectively for the period studied. Annual average mixing ratios of oxides of nitrogen (NO_x) and CO were observed to be 3.9±0.6 ppbv and 436±64 ppbv, respectively.     

Feasibility study of carbon capture and storage on NLC India Ltd

India is one of the largest growing economies in the world. It has a GDP of 2487.94 billion US dollars as of 2017. Around 61.297% of power generation is by utilising abundantly available lignite blended with imported coal. India is slowly cutting out its demand for imported coal from other countries. It has built its own lignite-based power plant to overcome the need of imported coal. The impact on cost of electricity (COE) and net power output (NPO) after retrofitting carbon capture and storage (CCS) over a lignite-based power plant of India is analysed. In this paper, a feasibility study is carried out for NLC India Ltd Barsingsar power plant by retrofitting CCS. The results obtained from the Integrated Environmental Control Model (IECM) Software are positively strong enough to encourage CCS implementation. Various strategies for utilising the CO₂ capture and carbon storage sites are suggested.     

Behaviour of CI engine performance,combustion and exhaust emission with neem biodiesel at varied fuel injection rates

Motorisation and fast depletion of fossil fuel reserves and issues like global warming have led the researchers all over to look for substitute fuels. Biodiesel resulting from vegetable oil is being used around the globe to lessen air pollution and reduce the necessity of diesel fuel. The current study covers the various aspects of N20 neem biodiesel with increased fuel injection pressure. The blends of N20 were tested with increased fuel injection pressure to examine the characteristics such as brake thermal efficiency, fuel consumption, emission and combustion parameters. Experimental results indicated that N20 with 240?bar has a closer performance to diesel, reduced exhaust emission and improved combustion parameters.     

Effect of methanol gasoline blended fuels on the performance and emissions of SI engine

This article presents experimental results of the effect of methanol gasoline blends as alternate fuels for the spark ignition (SI) engine. As the cost of the gasoline is periodically increasing the quest for the alternative fuels are evolved with which the emissions are reduced along with improved engine performance. A set of experiments have been conducted to investigate the effect of gasoline methanol blends in methanol percentages of M5, M10 and M15 on the engine performance and emissions. A significant reduction in emissions is observed with methanol blends compared to the standard gasoline with improved engine performance and emission characteristics. The fuels blends ranging from M10 to M15 have been found suitable for reduced emissions and improved engine performance.