Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethylcellulose matrices

To select a suitable formulation for the development of transdermal drug-delivery system of diltiazem hydrochloride. Transdermal patches of the drug, employing different ratios of polymers, ethylcellulose (EC), and povidone (PVP) were developed and evaluated for the potential drug delivery using depilated freshly excised abdominal mouse skin. The influence of different film compositions on in vitro drug permeation into receptor fluid were studied using a modified Franz diffusion cell. The cumulative amount of drug was found to be proportional to the square root of time, i.e., Higuchi kinetics. From this study, it was concluded that the films composed of povidone:ethylcellulose (1:2) should be selected for the development of transdermal drug-delivery system of diltiazem hydrochloride, using a suitable adhesive layer and backing membrane, for potential therapeutic use.     

Modeling mobile source emissions in presence of stationary sources

The impact of oxides of nitrogen (NO(x)) emissions from motor vehicles to the air quality in city-state Singapore is analyzed using AIRVIRO, a regional scale dispersion model developed by the Swedish Meteorological and Hydrological Institute. In a predominantly urban location like Singapore, it is difficult to separate out the contribution of pollutants from mobile and point sources at different locations. In this work, a new approach is used by first modeling only the impact of point and area sources and then overlaying the traffic impact on air quality at different locations. Monthly scenario simulations are run with point, area and traffic sources of emissions for the Gaussian model validation. Street Canyon modeling is used for street segments surrounded by buildings on either side. A simplified photochemical model, which takes into account NO(x) undergoing chemical transformations in the urban atmosphere, is used to account for variations in NO(x) and ozone levels with respect to traffic data. The diurnal variation of NO(x) concentration levels is studied as a function of ozone levels at site, hourly traffic counts and meteorological parameters. The impact on ambient air quality within the breathing zone of the public from mobile sources, is found to be about 40% at urban stations although overall emissions from mobile sources is only 24%. The proposed approach appears to predict the variations in NO(x) as a function of traffic and meteorological conditions.     

Cold Simulation of Metalloids Transport in Blast Furnaces

Metalloids normally get transferred at the interface of metal droplets passing through the slag system in the dropping zone and at the slag‐metal interface in the hearth zone in the lower region of a blast furnace. In these high temperature processes, the mass transport being the rate‐controlling factor, the viscosity of the slag system determines the kinetics of the refining reactions accompanied by mass and heat transfer at the metal droplets and slag interface. Slag systems generally possess random network structures comprising internal regions of weak ordering. The presence of these regions may result in non‐Newtonian behaviour of the slag. The rheological characteristics of a fluid relating to its network structure is expressed in terms of the indices consistency (k') and flow behaviour (n'). The extent of metalloids presence in hot metal is subjected to their residence time at the slag‐metal interface. The metal droplet descent through a surrounding fluid system has been studied and a co‐relation between drag Reynolds number and modified Reynolds number has been obtained. This correlation has been used to determine the drag velocity of a metal droplet falling through a slag system and the residence time distribution (RTD) of the metalloids at the slag‐metal interface in the lower region of the blast furnace.     

Microstructure and properties of lead-free (Bi<Subscript>1/2</Subscript>Na<Subscript>1/2</Subscript>)TiO<Subscript>3 </Subscript>based piezoelectric ceramics doped with different cations

Different cations doped lead-free piezoelectric (Bi_1/2Na_1/2)TiO₃ ceramics with the general formula Na_0.4995Bi_0.4995Ba_0.001Ti_0.998M_0.002O₃ (M = Nb, Ta, and Sb) were fabricated. The effects of processing parameters and doping on phase content, microstructure, dielectric and piezoelectric properties of the materials were discussed. Experimental results show that Nb doped (Bi_1/2Na_1/2)TiO₃ exhibits superior polarization performance over the existing lead-free ceramics with a d₃₃ value of 122 pC/N obtained when poled at 60 kV/cm at room temperature. The best piezoelectric properties were achieved in (Bi_1/2Na_1/2)TiO₃ doped with Ta having a measured d₃₃ value of 164 pC/N for samples poled at 100 °C under the applied field of 50 kV/cm.     

Hybrid Wireless-Optical Broadband-Access Network (WOBAN): A Review of Relevant Challenges

The hybrid wireless-optical broadband-access network (WOBAN) is a promising architecture for future access networks. Recently, the wireless part of WOBAN has been gaining increasing attention, and early versions are being deployed as municipal access solutions to eliminate the wired drop to every wireless router at customer premises. This architecture saves on network deployment cost because the fiber need not penetrate each end-user, and it extends the reach of emerging optical-access solutions, such as passive optical networks. This paper first presents an architecture and a vision for the WOBAN and articulates why the combination of wireless and optical presents a compelling solution that optimizes the best of both worlds. While this discussion briefly touches upon the business drivers, the main arguments are based on technical and deployment considerations. Consequently, the rest of this paper reviews a variety of relevant research challenges, namely, network setup, network connectivity, and fault-tolerant behavior of the WOBAN. In the network setup, we review the design of a WOBAN where the back end is a wired optical network, the front end is managed by a wireless connectivity, and, in between, the tail ends of the optical part [known as optical network unit (ONU)] communicate directly with wireless base stations (known as ldquogateway routersrdquo). We outline algorithms to optimize the placement of ONUs in a WOBAN and report on a survey that we conducted on the distribution and types of wireless routers in the Wildhorse residential neighborhood of North Davis, CA. Then, we examine the WOBAN's routing properties (network connectivity), discuss the pros and cons of various routing algorithms, and summarize the idea behind fault-tolerant design of such hybrid networks.     

Mathematical formulation of provisioning of connections with advance reservation in metro WDM ring networks using reconfigurable OADMs (ROADMs) with tuning constraint

Optical add/drop multiplexers (OADMs) can significantly reduce the cost of metro optical wavelength-division multiplexing (WDM) ring networks by allowing traffic to bypass intermediate nodes without expensive opto-electro-opto (O-E-O) conversion. Some traditional OADMs, called fixed OADMs (FOADMs), can only add/drop traffic on a specific wavelength. Reconfigurable Optical Add/Drop Multiplexers (ROADMs) are emerging, which can add/drop traffic onto/from different wavelengths at different time. ROADMs provide desirable flexibility, enable fast provisioning of dynamic traffic, and save capital expenditure (CapEx) and operational expenditure (OpEx). In order to be cost-effective, some ROADMs employ architectures that tune the ROADM continuously from one wavelength to another, crossing through all the wavelengths in-between, which may cause interference to the connections, if any, on those wavelengths being crossed. In order to prevent existing connections from being interrupted, a constraint needs to be imposed that ROADMs cannot cross working wavelengths when tuning. In this study, the design and the benefits of metro optical WDM network architectures using ROADMs and the impact of this tuning constraint on the performance of the network are investigated. Mathematical formulation of the problem of provisioning of connections with advance reservation, in which the arrival time and departure time of all the connections are known in advance, is presented, and results for a small network are shown.     

Testing and Diagnosis of Realistic Defects in Digital Microfluidic Biochips

Microfluidics-based biochips are soon expected to revolutionize biosensing, clinical diagnostics and drug discovery. Robust off-line and on-line test techniques are required to ensure system dependability as these biochips are deployed for safety-critical applications. Due to the underlying mixed-technology and mixed-energy domains, biochips exhibit unique failure mechanisms and defects. We first relate some realistic defects to fault models and observable errors. We next set up an experiment to evaluate the manifestations of electrode-short faults. Motivated by the experimental results, we present a testing and diagnosis methodology to detect catastrophic faults and locate faulty regions. The proposed method is evaluated using a biochip performing real-life multiplexed bioassays.     

A physics‐based model of DC and microwave characteristics of GaN/AlGaN HEMTs

A physics‐based model of AlGaN/GaN High Electron Mobility Transistor (HEMT) is developed for the analysis of DC and microwave characteristics. Large‐ and small‐signal parameters are calculated for a given device dimensions and operating conditions. Spontaneous and piezoelectric polarizations at the heterointerface and finite effective width of the 2DEG gas have been incorporated in the analysis. The model predicts a maximum drain current of 523 mA/mm and transconductance of 138 mS/mm for a 1 μm × 75 μm device, which are in agreement with the experimental data. © 2007 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2007.