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11.
Drying of textile bobbins was carried out on two kinds of laboratory-scale dryers: in a cross circulation drying rig, atmospheric pressure heating air is used, while in the through circulation drying apparatus, the heating air is pressurized before the drying process takes place. In both cases, a bobbin was fitted with seven thermocouples, placed in a plane normal to the bobbin axis but at different radial distances, in order to provide temperature data during the drying process. In cross circulation drying, plots of temperature against time indicated the presence of two moving fronts, one starting from inside the bobbin, another from the outside, while in through circulation drying, similar plots showed the presence of an evaporation front, moving from inside the bobbin to the outside. In both canes, numerical models were developed to simulate the drying processes. 相似文献
12.
A semianalytical method to estimate the bit-error rate performance of nonsynchronous ASK and FSK optical heterodyne systems is presented. This approach takes into account numerous system details with an accuracy similar to Monte-Carlo simulation, but with a computation time reduced by several orders of magnitude. An analytical approximation, based on a closed-form expression for the decision variable moment generating function, is also presented. The results obtained with the semianalytical method and the analytical approximation are compared to Monte-Carlo simulation results and to measurements obtained on a practical FSK system 相似文献
13.
Monitoring of nitrate (NO3-) and nitrite (NO2-) content in agricultural products in Slovenia has been carried out since 1996. The results of monitoring over the period 1996-2002 are presented. During this time 924 samples of 14 different agricultural products (potato, lettuce, apples, carrot, silage maize, cabbage, grapes, peaches, string beans, cereals, pears, cucumbers, strawberries and tomato) were analysed. The samples were taken at the time of maturity directly from growing sites and they were analysed using segmented flow analysis. The average nitrate contents were the highest in lettuce (1074 mg kg-1), cabbage (881 mg kg-1), string beans (298 mg kg-1) and carrot (264 mg kg-1), and they were moderately high in potato (158 mg kg-1), silage maize (122 mg kg-1), strawberries (94 mg kg-1), cucumbers (93 mg kg-1) and cereals (49 mg kg-1). Low nitrate contents (below 6 mg kg-1) were found in fruit (grapes, peaches, apples and pears) and tomato. With the exception of cereals (8.9 mg kg-1), apples (1.5 mg kg-1), potato (1.2 mg kg-1) and pears (1.0 mg kg-1) the content of nitrites did not exceed 0.5 mg kg-1. It may be concluded that the results of the monitoring were in most cases similar to the results of investigations obtained in other countries. 相似文献
14.
Ana Magalhes Carlos Pinho 《Chemical Engineering and Processing: Process Intensification》2008,47(12):2395-2401
The spouted bed is commonly used to dry granular particles as it displays some special characteristics which render it capable of performing cyclic operations, with particles that are very difficult to fluidize under a different type of bed.Information on the characteristic drying rates of cork stoppers is still very limited in the technical and scientific literature, and until now no published data was found on the spouted bed drying of cork stoppers.The characterization of the drying performance of Port wine cork stoppers was carried out in a laboratory scale spouted bed. Characteristic drying curves were determined with 29 mm × 21 mm cork stoppers under several operating conditions. Values for the effective diffusivity were obtained in the range of 1.36 × 10−9 to 4.44 × 10−9 m2/s, with the temperature dependence represented by an Arrhenius-type relationship. The activation energy obtained was 28.72 kJ/mol. 相似文献
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16.
Maria Buuales Maria Cristina Ballesteros-Briones Manuela Gonzalez-Aparicio Sandra Hervas-Stubbs Eva Martisova Uxua Mancheo Ana Ricobaraza Sara Lumbreras Cristian Smerdou Ruben Hernandez-Alcoceba 《International journal of molecular sciences》2021,22(8)
Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of monoclonal antibodies (mAbs) using gene therapy vectors can alleviate this problem. In this work, we describe a high-capacity adenoviral vector (HCA-EFZP-aPDL1) equipped with a mifepristone-inducible system for the controlled expression of an anti-programmed death ligand 1 (PD-L1) blocking antibody. The vector was tested in an immune-competent mouse model of colorectal cancer based on implantation of MC38 cells. A single local administration of HCA-EFZP-aPDL1 in subcutaneous lesions led to a significant reduction in tumor growth with minimal release of the antibody in the circulation. When the vector was tested in a more stringent setting (rapidly progressing peritoneal carcinomatosis), the antitumor effect was marginal even in combination with other immune-stimulatory agents such as polyinosinic-polycytidylic acid (pI:C), blocking mAbs for T cell immunoglobulin, mucin-domain containing-3 (TIM-3) or agonistic mAbs for 4-1BB (CD137). In contrast, macrophage depletion by clodronate liposomes enhanced the efficacy of HCA-EFZP-aPDL1. These results highlight the importance of addressing macrophage-associated immunoregulatory mechanisms to overcome resistance to ICIs in the context of colorectal cancer. 相似文献
17.
Progressive ladder topology is studied by consideration of its properties of power budget and coupler tailoring. Optimization criteria are addressed for lossless and real systems, and their basic characteristics are compared with other topologies. Numerical results are presented, and an experiment is described for the case in which the network supports interferometric and intensity (with referentiation) fiber-optic-based sensors. 相似文献
18.
19.
J. P. Carmo M. F. Silva J. F. Ribeiro R. F. Wolffenbuttel P. Alpuim J. G. Rocha L. M. Gon?alves J. H. Correia 《Microsystem Technologies》2011,17(8):1283-1291
This paper presents an approach for generating a well-defined cooling pattern over an area of tissue. An array of solid-state
microcoolers is used, which could be included in a probe that provides local cooling. This medical instrument can be used
for removal of scar tissue in the eye or for the rapid stopping of bleeding due to micro-cuts, which makes it a useful tool
to medical doctors and could make surgery more secure to the patient. The array of microcoolers is composed of 64 independent
thermo-electric elements, each controlled using an integrated circuit designed in CMOS. The independent control allows the
flexible programming of the surface temperature profile. This type of control is very suitable in case abrupt temperature
steps should be avoided. Cooling by lateral heat flow was selected in order to minimize the influence of heat by dissipation
from the electronic circuits. Moreover, a thermo-electric component with lateral heat allows fabrication of the cooling elements
using planar thin-film technology, lithography and wet etching on top of the silicon wafer. This approach is potentially CMOS
compatible, which would allow for the fabrication of the thermo-electric elements on top of a pre-fabricated CMOS wafer as
a post-process step. Each pixel is composed of thin-films of n-type bismuth telluride, Bi2Te3 and p-type antimony telluride, Sb2Te3, which are electrically interconnected as thermocouple. These materials have excellent thermoelectric characteristics, such
as thermoelectric figures-of-merit, ZT, at room temperatures of 0.84 and 0.5, respectively, which is equivalent to power-factors, PF, of 3.62 × 10−3 W K−1 m−2 and 2.81 × 10−3 W K−1 m−2, respectively. The theoretical study presented here demonstrates a cooling capability of 15°C at room temperature (300 K ≈ 27°C).
This cooling performance is sufficient to maintain a local tissue temperature at 25°C, which makes it suitable for the intended
application. A first prototype was successfully fabricated to demonstrate the concept. 相似文献
20.
The Principal Component Regression model of multiple responses is extended to forccast a continuous-time stochastic process. Orthogonal projection on a subspace of trigonometric functions is applied in order to estimate the principal components using discrete-time observations from a sample of regular curves. The forecasts provided by this approach are compared with classical principal component regression on simulated data. 相似文献