Modeling the deformation of RBMK graphite columns surrounding a damaged cell with a ruptured channel pipe taking aging into account

The results of modeling of the deformation of RBMK graphite columns surrounding a damaged cell with a rupture channel tube and analysis of the possibility of multiple rupture of the tubes in such columns as a result of the action of the steam–water mixture flowing out of the rupture are presented. The aging of the masonry is taken into account in connection with RBMK service life extension. The calculations of the kinetics of the deflections of the columns, surrounding a damaged cell, and the strength of the channel tubes of these columns showed that multiple ruptures of tubes following an emergency situation in accidents with an initial rupture of the RBMK process channel are impossible.     

Structure and development of causal€xperimental thought: From early adolescence to youth.

Investigated the structure and development of causal–experimental thought. 260 Ss (aged 12–16 yrs) were examined by 3 test batteries. The batteries involved items addressing combinatorial, hypothesis handling, experimentation, and model construction abilities. Confirmatory factor analysis indicated that these abilities, although distinct from each other, do share a common functional core, and they are organized in a higher order causal–experimental specialized structural system. Rasch scaling indicated that these 4 kinds of abilities follow overlapping developmental trajectories. Saltus modeling suggested that development is continuous rather than discontinuous. Individual differences were found in the rate of acquisition but not in the structure of abilities. A model of synergic developmental causality was proposed to account for this pattern of development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Analysis of observer performance in known-location tasks for tomographic image reconstruction

We consider the task of detecting a statistically varying signal of known location on a statistically varying background in a reconstructed tomographic image. We analyze the performance of linear observer models in this task. We show that, if one chooses a suitable reconstruction method, a broad family of linear observers can exactly achieve the optimal detection performance attainable with any combination of a linear observer and linear reconstructor. This conclusion encompasses several well-known observer models from the literature, including models with a frequency-selective channel mechanism and certain types of internal noise. Interestingly, the "optimal" reconstruction methods are unregularized and in some cases quite unconventional. These results suggest that, for the purposes of designing regularized reconstruction methods that optimize lesion detectability, known-location tasks are of limited use.     

Ultrasonic Quality Control of Hydroacoustic Antennas

We consider the problem of nondestructive quality control of complex structured articles, in particular, hydroacoustic antennas. Those features in the structure of these products are determined that affect the choice of methods and means of such control. The possibility of using ultrasonic methods (in particular, the pulse echo method with immersion technique of acoustic contact) and means for monitoring the quality of hydroacoustic antennas have been investigated; means have been proposed to ensure the automation of control.

     

Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis

Piezo1/2 are mechanosensitive calcium-permeable channels that can be activated by various modes of membrane deformation. The identification of the small molecule Yoda1, a synthetic Piezo1 agonist, revealed the possibility of chemical activation of the channel. Stimulating effects of Yoda1 on Piezo1 have been mainly documented using over-expressing cellular systems or channel proteins incorporated in artificial lipid bilayers. However, the activating effect of Yoda1 on native Piezo1 channels in the plasma membrane of living cells remains generally undefined, despite the increasing number of studies in which the agonist is utilized as a functional tool to reveal the contribution of Piezo1 to cellular reactions. In the current study, we used the human myeloid leukemia K562 cell line as a suitable model to examine chemically induced Piezo1 activity with the use of the patch-clamp technique in various specific modes. The functional expression of Piezo1 in leukemia cells was evidenced using a combinative approach, including single channel patch-clamp measurements. Utilizing our established single-current whole-cell assay on K562 cells, we have shown, for the first time, the selective real-time chemical activation of endogenously expressed Piezo1. Extracellular application of 0.5–1 µM Yoda1 effectively stimulated single Piezo1 currents in the cell membrane.     

The DiamondCandy LRnLA algorithm: raising efficiency of the 3D cross-stencil schemes

The Journal of Supercomputing - The parallel efficiency is raised by increasing the locality of calculation. With the locally recursive non-locally asynchronous algorithms method, we have...     

Comparison analysis of graphene oxide reduction methods

Abstract

Graphene oxide was reduced by aspartic acid, β-mercaptoethanol in the acidic mixture, hydrothermal method and by atomic hydrogen (deuterium and tritium). Raman spectroscopy and FTIR indicate high reduction efficiency of hydrothermal method. FTIR indicates that atomic hydrogen results in the formation C_sp3H-bonds on the graphene surface. Graphene oxide can be effectively reduced by β-mercaptoethanol in the acidic mixture even at room temperature.     

Enrichment of Inorganic Martian Dust Simulant with Carbon Component can Provoke Neurotoxicity

Carbon is the most abundant dust-forming element in the interstellar medium. Tremendous amount of meteorites containing plentiful carbon and carbon-enriched dust particles have reached the Earth daily. National Institute of Health panel accumulates evidences that nano-sized air pollution components may have a significant impact on the central nervous system (CNS) in health and disease. During inhalation, nano-/microsized particles are efficiently deposited in nasal, tracheobronchial, and alveolar regions and can be transported to the CNS. Based on above facts, here we present the study, the aims of which were: 1) to upgrade inorganic Martian dust simulant derived from volcanic ash (JSC-1a/JSC, ORBITEC Orbital Technologies Corporation, Madison, Wisconsin) by the addition of carbon components, that is, nanodiamonds and carbon dots; 2) to analyse acute effects of upgraded simulant on key characteristics of synaptic neurotransmission; and 3) to compare above effects with those of inorganic dust and carbon components per se. Acute administration of carbon-containing Martian dust analogues resulted in a significant decrease in transporter-mediated uptake of L-[¹⁴C]glutamate (the major excitatory neurotransmitter) and [³H]GABA (the main inhibitory neurotransmitter) by isolated rat brain nerve terminals. The extracellular level of both neurotransmitters increased in the presence of carbon-containing Martian dust analogues. These effects were associated with action of carbon components of upgraded Martian dust simulant, but not with its inorganic constituent. This fact indicates that carbon component of native Martian dust can have deleterious effects on extracellular glutamate and GABA homeostasis in the CNS, and so glutamate- and GABA-ergic neurotransmission disballansing exitation and inhibition.     

CANDYBOTS: A New Generation of 3D-Printed Sugar-Based Transient Small-Scale Robots

Sugars are ubiquitous in food, and are among the main sources of energy for almost all forms of life. Sugars can also form structural building blocks such as cellulose in plants. Because of their inherent degradability and biocompatibility characteristics, sugars are compelling materials for transient devices. Here, an additive manufacturing approach for the production of magnetic sugar-based composites is introduced. First, it is shown that sugar-based 3D architectures can be 3D printed by selective laser sintering. This method enables not only the caramelization chemistry but also the mechanical properties of the sugar architectures to be adjusted by varying the laser energy. It is also demonstrated that mixtures of sugar and magnetic particles can be processed as 3D composites. As a proof of concept, a sugar-based millimeter-scale helical swimmer, which is capable of corkscrew motion in a solution with a viscosity comparable to those of biological fluids, is fabricated. The millirobot quickly dissolves in water, while being manipulated through magnetic fields. The present fabrication method can pave the way to a new generation of transient sugar-based small-scale robots for minimally invasive procedures. Due to their rapid dissolution, sugars can be used as an intermediate step for transporting swarms of particles to specific target locations.