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961.
962.
963.
Schlosser Fernando Schwindt Claudio Fuster Valeria Tommasi Andrea Signorelli Javier Walter 《Metallurgical and Materials Transactions A》2017,48(6):2858-2867
Metallurgical and Materials Transactions A - The use of zinc sheets has largely increased in the last years, fundamentally because of new tendencies in architecture and, at the same time, due to... 相似文献
964.
Fabio Forghieri Giovanni Riva Ivana Lagreca Patrizia Barozzi Francesca Bettelli Ambra Paolini Vincenzo Nasillo Beatrice Lusenti Valeria Pioli Davide Giusti Andrea Gilioli Corrado Colasante Laura Galassi Hillary Catellani Francesca Donatelli Annalisa Talami Rossana Maffei Silvia Martinelli Leonardo Potenza Roberto Marasca Enrico Tagliafico Rossella Manfredini Tommaso Trenti Patrizia Comoli Mario Luppi 《International journal of molecular sciences》2021,22(17)
The C-terminal aminoacidic sequence from NPM1-mutated protein, absent in normal human tissues, may serve as a leukemia-specific antigen and can be considered an ideal target for NPM1-mutated acute myeloid leukemia (AML) immunotherapy. Different in silico instruments and in vitro/ex vivo immunological platforms have identified the most immunogenic epitopes from NPM1-mutated protein. Spontaneous development of endogenous NPM1-mutated-specific cytotoxic T cells has been observed in patients, potentially contributing to remission maintenance and prolonged survival. Genetically engineered T cells, namely CAR-T or TCR-transduced T cells, directed against NPM1-mutated peptides bound to HLA could prospectively represent a promising therapeutic approach. Although either adoptive or vaccine-based immunotherapies are unlikely to be highly effective in patients with full-blown leukemia, these strategies, potentially in combination with immune-checkpoint inhibitors, could be promising in maintaining remission or preemptively eradicating persistent measurable residual disease, mainly in patients ineligible for allogeneic hematopoietic stem cell transplant (HSCT). Alternatively, neoantigen-specific donor lymphocyte infusion derived from healthy donors and targeting NPM1-mutated protein to selectively elicit graft-versus-leukemia effect may represent an attractive option in subjects experiencing post-HSCT relapse. Future studies are warranted to further investigate dynamics of NPM1-mutated-specific immunity and explore whether novel individualized immunotherapies may have potential clinical utility in NPM1-mutated AML patients. 相似文献
965.
Daniela Lisini Sara Lettieri Sara Nava Giulia Accordino Simona Frigerio Chandra Bortolotto Andrea Lancia Andrea Riccardo Filippi Francesco Agustoni Laura Pandolfi Davide Piloni Patrizia Comoli Angelo Guido Corsico Giulia Maria Stella 《International journal of molecular sciences》2021,22(16)
Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so far in the MPM. Combination immunotherapy might achieve better results over chemotherapy alone, but there is still a need for more effective therapeutic approaches. Based on the peculiar disease features of MPM, several strategies for local therapeutic delivery have been developed over the past years. The common rationale of these approaches is: (i) to reduce the risk of drug inactivation before reaching the target tumor cells; (ii) to increase the concentration of active drugs in the tumor micro-environment and their bioavailability; (iii) to reduce toxic effects on normal, non-transformed cells, because of much lower drug doses than those used for systemic chemotherapy. The complex interactions between drugs and the local immune-inflammatory micro-environment modulate the subsequent clinical response. In this perspective, the main interest is currently addressed to the development of local drug delivery platforms, both cell therapy and engineered nanotools. We here propose a review aimed at deep investigation of the biologic effects of the current local therapies for MPM, including cell therapies, and the mechanisms of interaction with the tumor micro-environment. 相似文献
966.
Sara Nganga Andrea Travan Eleonora Marsich Ivan Donati Eva Söderling Niko Moritz Sergio Paoletti Pekka K. Vallittu 《Journal of materials science. Materials in medicine》2013,24(12):2775-2785
Biostable fiber-reinforced composite (FRC) implants prepared from bisphenol-A-dimethacrylate and triethyleneglycoldimethacrylate resin reinforced with E-glass fibers have been successfully used in cranial reconstructions in 15 patients. Recently, porous FRC structures were suggested as potential implant materials. Compared with smooth surface, porous surface allows implant incorporation via bone ingrowth, but is also a subject to bacterial attachment. Non-cytotoxic silver–polysaccharide nanocomposite coatings may provide a way to decrease the risk of bacterial contamination of porous FRC structures. This study is focused on the in vitro characterization of the effect porosity on the antimicrobial efficiency of the coatings against Staphylococcus aureus and Pseudomonas aeruginosa by a series of microbiological tests (initial adhesion, antimicrobial efficacy, and biofilm formation). Characterization included confocal laser scanning microscopy and scanning electron microscopy. The effect of porosity on the initial attachment of S. aureus was pronounced, but in the case of P. aeruginosa the effect was negligible. There were no significant effects of the coatings on the initial bacterial attachment. In the antimicrobial efficacy test, the coatings were potent against both strains regardless of the sample morphology. In the biofilm tests, there were no clear effects either of morphology or of the coating. Further coating development is foreseen to achieve a longer-term antimicrobial effect to inhibiting bacterial implant colonization. 相似文献
967.
Louise van der Werff Ilias Louis Kyratzis Andrea Robinson Robin Cranston Gary Peeters Mike O’Shea Lance Nichols 《Journal of Materials Science》2013,48(14):5005-5011
A three-layered composite fibre has been generated via a modified wire-coating melt co-extrusion process. The continuous fibre consists of a thermochromic liquid crystalline (TLC) layer encapsulated between a transparent polypropylene outer sheath and a black polyether ether ketone inner core. The fibres exhibit clear thermochromic behaviour consistent with the behaviour of unincorporated TLCs, and have been formed into a textile. The presence of the black inner core was found to be the key for the clear retention of colour within the fibres against both white and black backgrounds. The temperature-sensitive fibres and textiles can be applied to a variety of thermal mapping applications, such as in the medical and engineering fields, due to the tunable nature of TLCs. 相似文献
968.
Nguyen Tien Phong Mohamed H. Gabr Le Hoai Anh Vu Minh Duc Andrea Betti Kazuya Okubo Bui Chuong Toru Fujii 《Journal of Materials Science》2013,48(17):6039-6047
In this study, core–shell rubber (CSR) nanoparticles with approximate particle size of 35 nm were used as a modifier for the epoxy polymer. The effects of various CSR contents in the epoxy matrix on mode I interlaminar fracture toughness, tensile strength, and fatigue life of the carbon fabric reinforced epoxy (CF/EP) composites were investigated. The experimental results showed that the mode I interlaminar fracture toughness at crack initiation and propagation significantly improved by 71.21 and 58.47 %, respectively, when 8.0 wt% CSR was dispersed in the epoxy matrix. The fatigue life of the modified CF/EP composites at all of CSR contents dramatically increased 75–100 times longer than that of the unmodified CF/EP composites at high cycle fatigue while tensile strength slightly increased by about 10 %. Field emission scanning electron microcopy (FESEM) observations of the fracture surfaces were conducted to explain failure mechanisms of CSR addition to the CF/EP composites. The evidences of the rubber nanoparticle debonding, plastic void growth, and microshear banding were credited for delaying the onset of matrix crack, and reducing the crack growth rate, as a result, attributed to increase in the mechanical properties of the CF/EP composites. 相似文献
969.
Paula Brown Richard Jay Andrea Fox Matthew Oliver 《Hemodialysis international. International Symposium on Home Hemodialysis》2013,17(3):444-449
Heparin‐induced thrombocytopenia (HIT) is a potentially life‐threatening condition that can develop after exposure to unfractionated or low–molecular‐weight heparins. Treatment options appear to be limited in patients on concurrent intermittent hemodialysis. We report the case of an 88‐year‐old man newly initiated on high‐flux hemodialysis who developed HIT and extracorporeal circuit thrombosis after 3 weeks of exposure to unfractionated heparin. Our patient was successfully treated with fondaparinux 2.5 mg subcutaneously three times per week and citrate during dialysis sessions. Antifactor Xa levels were measured on several occasions while receiving fondaparinux. 相似文献
970.
Daniele Chiappe Andrea Toma Francesco Buatier de Mongeot 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(6):913-919
A self‐organised approach for the synthesis of transparent metal nanowire arrays is based on defocused ion beam sputtering. The nanowire arrays, supported on low‐cost dielectric substrates (glass slides), feature a dual functionality: they exhibit anisotropic conductivity, with sheet resistances which are reduced in comparison to those of transparent conductive oxides, and additionally they support localised plasmon resonances. The latter represents an attractive feature in view of plasmon enhanced photon harvesting applications, in which the nanostructured metal electrodes are employed as an alternative to conventional transparent conductive oxides. 相似文献