Particle Detachment from Rough Surfaces in Turbulent Flows: An Analytical Expression for Resuspension Fraction

The critical shear velocity for resuspension of micrometer size particles from rough surfaces was studied. The random variation of surface roughness was accounted for. The recently developed Monte Carlo simulations accounted for the statistical variations of physical parameters that control the particle resuspension process. A sensitivity analysis showed that the surface roughness and its random variation was the key factor affecting the particle resuspension from rough surfaces. The theory of probabilistic transformation was used and an analytical expression for evaluating the resuspension fraction of particles of different sizes from rough surfaces versus the shear velocity was developed. The resuspension fractions as predicted by the analytical model were evaluated for several particles sizes for a range of turbulent flow shear velocities. The resulting resuspension fractions were compared with those obtained from the Monte Carlo simulations as well as the available experimental data. It was found that the predictions of the new analytical equation were in good agreement with the Monte Carlo simulation results and the experimental data, especially for smaller size particles. This new analytical expression could be used as a simple empirical equation for estimating flow-induced resuspension of particles from rough surfaces.     

High-rate quantum key distribution at short wavelength: Performance analysis and evaluation of silicon single photon avalanche diodes

Abstract

Experimental results obtained with silicon single photon avalanche diodes (SPADs) in quantum key distribution (QKD) at short wavelengths reveal remarkable potential for application in local area networks (LAN) and for free-space transmission at high rate. Actual application prospects, however, depend on the performance level and on the suitability of practical systems using the available silicon SPAD devices. They can be essentially divided in two groups: planar p-n junction structures with a thin depletion layer (typically 1 μm); and reach-through structures with a thick depletion layer (from 20 μm to 150μm). The physical mechanisms that control the device behaviour were investigated and the effect on the key parameters of the detector (quantum detection efficiency, dark counting rate, afterpulsing probability and photon-timing jitter) were thoroughly assessed. A quantitative analysis was made of the influence of such parameters on the quantum bit error rate (QBER). Actual parameters were measured and the attainable performance and system suitability of the two device types evaluated. Comparable performance is obtained, but from a system viewpoint thin SPADs appear inherently better suited to high-rate QKD applications, because of their faster response time, ruggedness, low voltage, low power dissipation and fabrication technology, which is simple, efficient, economical and compatible with monolithic integration of detector and associated circuits.     

Aggregation-Induced Circularly Polarized Luminescence: Chiral Organic Materials for Emerging Optical Technologies

Chirality is becoming increasingly important in the design of organic materials with functional properties, when bulk anisotropy is needed. In the past decades, a plethora of chiral organic materials have been studied and developed. Nanostructures have brought substantial advancement to the realization of organic-molecule-based devices, and the possibilities for solid-state light emission are very promising in view of potential applications. Scientific approaches to the realization of chiral emissive materials are indeed growing exponentially. The chiral nanostructures discussed are related both to the way in which luminescence is generated and the way in which it is detected. As to the former, the focus will be on organic chromophores with aggregation-induced emission properties, so that emission is present, or at least largely amplified, when the molecules are in the aggregated state. As to the latter, the focus will be on the ability and a quantitative comparison of organic nanostructures capable of circularly polarized emission.     

CANDYBOTS: A New Generation of 3D-Printed Sugar-Based Transient Small-Scale Robots

Sugars are ubiquitous in food, and are among the main sources of energy for almost all forms of life. Sugars can also form structural building blocks such as cellulose in plants. Because of their inherent degradability and biocompatibility characteristics, sugars are compelling materials for transient devices. Here, an additive manufacturing approach for the production of magnetic sugar-based composites is introduced. First, it is shown that sugar-based 3D architectures can be 3D printed by selective laser sintering. This method enables not only the caramelization chemistry but also the mechanical properties of the sugar architectures to be adjusted by varying the laser energy. It is also demonstrated that mixtures of sugar and magnetic particles can be processed as 3D composites. As a proof of concept, a sugar-based millimeter-scale helical swimmer, which is capable of corkscrew motion in a solution with a viscosity comparable to those of biological fluids, is fabricated. The millirobot quickly dissolves in water, while being manipulated through magnetic fields. The present fabrication method can pave the way to a new generation of transient sugar-based small-scale robots for minimally invasive procedures. Due to their rapid dissolution, sugars can be used as an intermediate step for transporting swarms of particles to specific target locations.     

Nebulized Gadolinium‐Based Nanoparticles: A Theranostic Approach for Lung Tumor Imaging and Radiosensitization

Lung cancer is the most common and most fatal cancer worldwide. Thus, improving early diagnosis and therapy is necessary. Previously, gadolinium‐based ultra‐small rigid platforms (USRPs) were developed to serve as multimodal imaging probes and as radiosensitizing agents. In addition, it was demonstrated that USRPs can be detected in the lungs using ultrashort echo‐time magnetic resonance imaging (UTE‐MRI) and fluorescence imaging after intrapulmonary administration in healthy animals. The goal of the present study is to evaluate their theranostic properties in mice with bioluminescent orthotopic lung cancer, after intrapulmonary nebulization or conventional intravenous administration. It is found that lung tumors can be detected non‐invasively using fluorescence tomography or UTE‐MRI after nebulization of USRPs, and this is confirmed by histological analysis of the lung sections. The deposition of USRPs around the tumor nodules is sufficient to generate a radiosensitizing effect when the mice are subjected to a single dose of 10 Gy conventional radiation one day after inhalation (mean survival time of 112 days versus 77 days for irradiated mice without USRPs treatment). No apparent systemic toxicity or induction of inflammation is observed. These results demonstrate the theranostic properties of USRPs for the multimodal detection of lung tumors and improved radiotherapy after nebulization.     

Harnessing adaptive capacity to close the pandora’s box of open innovation

ABSTRACT

This paper focuses on how companies deploy structural properties of adaptive capacity (multiplexity, redundancy and loose coupling) to cope with the phenomenon of internal challenges of Open Innovation (OI) implementation, i.e. organisational and cultural changes. We developed a single case study, which offered significant findings. First, the multiplexity of relationships in OI settings helps to face the challenges of organisational and cultural changes by triggering trust formation and interaction. Second, redundancy has twofold elements: institutional logics redundancy triggers cultural change challenges which can be overcome through management practices and communications; task redundancy facilitates knowledge sharing and collaboration, thus helping to deal with organisational change challenges. Finally, loose coupling in OI settings facilitates social interconnectedness among members through management practices, helping to face organisational and cultural change challenges. We provide managerial and theoretical implication to deal with the challenges of OI in relation to both organisational and cultural changes.