Computer aided comparative analysis of the binding modes of the adenosine receptor agonists for all known subtypes of adenosine receptors

Molecular models of all known subtypes (A1, A2A, A2B, and A3) of the human adenosine receptors were built in homology with bovine rhodopsin. These models include the transmembrane domain as well as all extracellular and intracellular hydrophilic loops and terminal domains. The molecular docking of adenosine and 46 selected derivatives was performed for each receptor subtype. A binding mode common for all studied agonists was proposed, and possible explanations for differences in the ligand activities were suggested.     

SMOS first data analysis for sea surface salinity determination

Soil Moisture and Ocean Salinity (SMOS), launched on 2 November 2009, is the first satellite mission addressing sea surface salinity (SSS) measurement from space. Its unique payload is the Microwave Imaging Radiometer using Aperture Synthesis (MIRAS), a new two-dimensional interferometer designed by the European Space Agency (ESA) and operating at the L-band frequency. This article presents a summary of SSS retrieval from SMOS observations and shows initial results obtained one year after launch. These results are encouraging, but also indicate that further improvements at various data processing levels are needed and hence are currently under investigation.     

Incremental construction of minimal deterministic finite cover automata

We present a fast incremental algorithm for constructing minimal Deterministic Finite Cover Automata (DFCA) for a given language. Since it was shown that the minimal DFCA for a language L has less states than the minimal Deterministic Finite Automata (DFA) for the same language L, this technique seems to be the best choice for incrementally building the automaton for a large language, especially when the number of states in the DFCA is significantly less than the number of states in the corresponding minimal DFA. We have implemented the proposed algorithm and have tested it against the best-known DFCA minimization technique.     

Optimal high-voltage energization of corona-electrostaticseparators

The selection of the high-voltage supply can play an important role in the optimization of electrostatic separation processes. This paper aims to evaluate the influence of the main high-voltage parameters (waveform, polarity, level) on the efficiency of electrostatic separation, in the case of insulation-metal granular mixtures. A roll-type laboratory high-tension separator was employed for the experimental study, and the tests were carried out with samples of granular materials taken from the technological flowsheet of a recycling plant for electric wire scraps. The oscillograms of the voltage and of the current across the separator proved to be of great use for studying the transition from corona to spark discharges. The experiments, performed under various operating conditions (roll speed, roll radius, high-voltage level, interelectrode distance), show the existence of a strong interdependence between these parameters, the frequency of spark discharges, and the efficiency of the separation process. The reported results suggest that monitoring the frequency of the spark discharges could be of use for controlling the optimum operating voltage for a given electrostatic separation application. Although the full-wave rectifier allows for lower operating voltages than the half-wave rectifier, its general effectiveness in electrostatic separation processes is superior. Good insulation-metal electrostatic separation can be achieved at either positive or negative polarity of the high-voltage supply, but negative electrode energization is recommended for most industrial applications     

Green laser sources optimized for highly efficient microdisplay‐based field‐sequential mobile projectors

Abstract— A novel green laser source, based on a monolithic cavity microchip laser platform, has been developed. The laser is designed to be a part of a miniature and efficient RGB light source for microdisplay‐based mobile projector devices. The use of highly efficient, periodically poled MgO‐doped lithium niobate as the non‐linear frequency doubler allows for a significant increase in the overall efficiency of the green microchip laser. Specifically, a 50–150‐mW green output with a wall‐plug efficiency exceeding 10% in the temperature range of greater than 40°C has been demonstrated. A compact package for this laser source with a volume less than 0.33 cm³ is discussed and results of performance tests are presented.     

SnapPaste: an interactive technique for easy mesh composition

Editing and manipulation of existing 3D geometric objects are a means to extend their repertoire and promote their availability. Traditionally, tools to compose or manipulate objects defined by 3D meshes are in the realm of artists and experts. In this paper, we introduce a simple and effective user interface for easy composition of 3D mesh-parts for non-professionals. Our technique borrows from the cut-and-paste paradigm where a user can cut parts out of existing objects and paste them onto others to create new designs. To assist the user attach objects to each other in a quick and simple manner, many applications in computer graphics support the notion of “snapping”. Similarly, our tool allows the user to loosely drag one mesh part onto another with an overlap, and lets the system snap them together in a graceful manner. Snapping is accomplished using our Soft-ICP algorithm which replaces the global transformation in the ICP algorithm with a set of point-wise locally supported transformations. The technique enhances registration with a set of rigid to elastic transformations that account for simultaneous global positioning and local blending of the objects. For completeness of our framework, we present an additional simple mesh-cutting tool, adapting the graph-cut algorithm to meshes.     

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox^® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present.     

Doping effects of Li–Sb content on the structure and electrical properties of [(Na0.5K0.5)1 − x(Li)x(Sb)x(Nb)1 − xO3] lead-free piezoelectric ceramics

Ceramic samples of [Na_0.5K_0.5]_1 ? x(Li)_x(Sb)_x(Nb)_1 ? xO₃ (NKNLS) (x = 0.04–0.06) were prepared by high temperature solid-state reaction method. X-ray diffraction analysis of the powder samples suggests the formation of a single-phase material with transformation from orthorhombic to tetragonal crystal structure with increase in Sb content. Dielectric studies show a diffuse phase transition about 100 °C and another phase ferroelectric–paraelectric transition at 330 °C. Polarization vs. electric field (P–E) hysteresis studies show maximum remanent polarization (Pr ～ 0.66 C m^?2) for composition x = 0.05. AC conductivity in the compound increases with increase in temperature which may be attributed due to oxygen vacancies and show negative temperature coefficient of resistance (NTCR) effect.     

Pulsed neutron source measurements in the subcritical ADS experiment YALINA-Booster

A subcritical zero-power source-driven coupled core, the YALINA-Booster, has been constructed for experimental investigations of neutron kinetics of source-driven systems. In this study, the reactivity of two subcritical configurations has been determined by the area ratio method. The prompt neutron decay constants have been evaluated through slope fitting of the prompt neutron decay as well as through the pulsed Rossi-α method. It is shown that the slope fitting method and the pulsed Rossi-α method give stable results whereas the area ratio method results show spatial dependence. The reasons for the spatial spread are addressed.     

CPM: a deformable model for shape recovery and segmentation based on charged particles

A novel, physically motivated deformable model for shape recovery and segmentation is presented. The model, referred to as the charged-particle model (CPM), is inspired by classical electrodynamics and is based on a simulation of charged particles moving in an electrostatic field. The charges are attracted towards the contours of the objects of interest by an electrostatic field, whose sources are computed based on the gradient-magnitude image. The electric field plays the same role as the potential forces in the snake model, while internal interactions are modeled by repulsive Coulomb forces. We demonstrate the flexibility and potential of the model in a wide variety of settings: shape recovery using manual initialization, automatic segmentation, and skeleton computation. We perform a comparative analysis of the proposed model with the active contour model and show that specific problems of the latter are surmounted by our model. The model is easily extendable to 3D and copes well with noisy images.