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101.
In this paper, we introduce the concept of detectable perturbations as a method to generate tests that cover any technology-specific faults such as multiple bridging, open and stuck-at faults. Rather than devising a customized test pattern generation system for each class of technology-specific faults, we implemented a generic system to generate tests for single and multiple perturbations. We demonstrate the versatility of this approach by generating tests for a set of large benchmark circuits that have been mapped into single- and multi-output modules. These tests cover single stuck-at, multi-output bridging, stuck-at, as well as any mutation faults in the functionality of the technology-mapped cells. Experimental results provide useful insights about the quality of single stuck-at test patterns versus coverages for the additional classes of faults. 相似文献
102.
A hybrid quadrupole time-of-flight mass spectrometer featured with ion trapping capabilities was employed for quantitative profiling of total extracts of endogenous phospholipids. Simultaneous acquisition of precursor ion spectra of multiple fragment ions allowed detection of major classes of phospholipids in a single experiment. Relative changes in their concentration were monitored using a mixture of isotopically labeled endogenous lipids as a comprehensive internal standard. Precursor ion scanning spectra were acquired simultaneously for acyl anions of major fatty acids in negative ion mode and identified the fatty acid moieties and their relative position at the glycerol backbone in individual lipid species. Taken together, a combination of multiple precursor ion scans allowed quantitative monitoring of major perturbation in phospholipid composition and elucidating of molecular heterogeneity of individual lipid species. 相似文献
103.
The paper presents a two-layered system for (1) learning and encoding a periodic signal without any knowledge on its frequency
and waveform, and (2) modulating the learned periodic trajectory in response to external events. The system is used to learn
periodic tasks on a humanoid HOAP-2 robot. The first layer of the system is a dynamical system responsible for extracting
the fundamental frequency of the input signal, based on adaptive frequency oscillators. The second layer is a dynamical system
responsible for learning of the waveform based on a built-in learning algorithm. By combining the two dynamical systems into
one system we can rapidly teach new trajectories to robots without any knowledge of the frequency of the demonstration signal.
The system extracts and learns only one period of the demonstration signal. Furthermore, the trajectories are robust to perturbations
and can be modulated to cope with a dynamic environment. The system is computationally inexpensive, works on-line for any
periodic signal, requires no additional signal processing to determine the frequency of the input signal and can be applied
in parallel to multiple dimensions. Additionally, it can adapt to changes in frequency and shape, e.g. to non-stationary signals,
such as hand-generated signals and human demonstrations.
相似文献
Auke J. IjspeertEmail: |
104.
Denis Forte Andrej Gams Jun Morimoto Aleš Ude 《Robotics and Autonomous Systems》2012,60(10):1327-1339
Autonomous robots cannot be programmed in advance for all possible situations. Instead, they should be able to generalize the previously acquired knowledge to operate in new situations as they arise. A possible solution to the problem of generalization is to apply statistical methods that can generate useful robot responses in situations for which the robot has not been specifically instructed how to respond. In this paper we propose a methodology for the statistical generalization of the available sensorimotor knowledge in real-time. Example trajectories are generalized by applying Gaussian process regression, using the parameters describing a task as query points into the trajectory database. We show on real-world tasks that the proposed methodology can be integrated into a sensory feedback loop, where the generalization algorithm is applied in real-time to adapt robot motion to the perceived changes of the external world. 相似文献
105.
The corrosion performance of anodised magnesium and its alloys, such as commercial purity magnesium (CP-Mg) and high-purity magnesium (HP-Mg) ingots, magnesium alloy ingots of MEZ, ZE41, AM60 and AZ91D and diecast AM60 (AM60-DC) and AZ91D (AZ91D-DC) plates, was evaluated by salt spray and salt immersion testing. The corrosion resistance was in the sequential order: AZ91D ≈ AM60 ≈ MEZ ? AZ91D-DC ? AM60-DC > HP-Mg > ZE41 > CP-Mg. It was concluded the corrosion resistance of an anodised magnesium alloy was determined by the corrosion performance of the substrate alloy due to the porous coating formed on the substrate alloy acting as a simple corrosion barrier. 相似文献
106.
Matej Janei
Katja Valjavec Kaja Bergant Loboda Barbara Herlah Iza Ogris Mirijam Kozorog Marjetka Podobnik Simona Goli
Grdadolnik Gerhard Wolber Andrej Perdih 《International journal of molecular sciences》2021,22(24)
In this study, we utilized human DNA topoisomerase IIα as a model target to outline a dynophore-based approach to catalytic inhibitor design. Based on MD simulations of a known catalytic inhibitor and the native ATP ligand analog, AMP-PNP, we derived a joint dynophore model that supplements the static structure-based-pharmacophore information with a dynamic component. Subsequently, derived pharmacophore models were employed in a virtual screening campaign of a library of natural compounds. Experimental evaluation identified flavonoid compounds with promising topoisomerase IIα catalytic inhibition and binding studies confirmed interaction with the ATPase domain. We constructed a binding model through docking and extensively investigated it with molecular dynamics MD simulations, essential dynamics, and MM-GBSA free energy calculations, thus reconnecting the new results to the initial dynophore-based screening model. We not only demonstrate a new design strategy that incorporates a dynamic component of molecular recognition, but also highlight new derivates in the established flavonoid class of topoisomerase II inhibitors. 相似文献
107.
Laura Collesano Isabella Guido Ramin Golestanian Andrej Vilfan 《Journal of the Royal Society Interface》2022,19(186)
Biological cilia pump the surrounding fluid by asymmetric beating that is driven by dynein motors between sliding microtubule doublets. The complexity of biological cilia raises the question about minimal systems that can re-create similar patterns of motion. One such system consists of a pair of microtubules that are clamped at the proximal end. They interact through dynein motors that cover one of the filaments and pull against the other one. Here, we study theoretically the static shapes and the active dynamics of such a system. Using the theory of elastica, we analyse the shapes of two filaments of different lengths with clamped ends. Starting from equal lengths, we observe a transition similar to Euler buckling leading to a planar shape. When further increasing the length ratio, the system assumes a non-planar shape with spontaneously broken chiral symmetry after a secondary bifurcation and then transitions to planar again. The predicted curves agree with experimentally observed shapes of microtubule pairs. The dynamical system can have a stable fixed point, with either bent or straight filaments, or limit cycle oscillations. The latter match many properties of ciliary motility, demonstrating that a two-filament system can serve as a minimal actively beating model. 相似文献
108.
Mei Y. A. Lo Andrej T. Gierczycki Nigel J. Titchener-Hooker Parviz Ayazi Shamlou 《加拿大化工杂志》1998,76(3):471-478
Power input data are presented for a twin flat disk up-and-down moving (vibromixer) impeller operating in a small vessel with a range of Newtonian liquids. Vibromixer power number and Reynolds number are defined and are used to establish the Newtonian power curve for this type of mixer. Drop size distributions are presented for xylene-in-water dispersions under turbulent flow conditions in the vibromixer and are shown to vary with the maximum velocity of the disk (2πAf). The Sauter mean drop diameter of the distribution is related to the vibromixer Weber number, (We =ρ(2πAf)2D/σ), by an equation of the type d32/D = C (We)?3/5 with the coefficient C = 0.37. 相似文献
109.
Anton Marcin
in Eva Krmendy Marcela Hricov Andrej Rusnk Arun Pal Aneja 《应用聚合物科学杂志》2006,102(5):4222-4227
The article deals with method of preparation, rheological properties, phase structure, and morphology of binary blend of poly(ethylene terephthalate) (PET)/poly(butylene terephthalate) (PBT) and ternary blends of polypropylene (PP)/(PET/PBT). The ternary blend of PET/PBT (PES) containing 30 wt % of PP is used as a final polymer additive (FPA) for blending with PP and subsequent spinning. In addition commercial montane (polyester) wax Licowax E (LiE) was used as a compatibilizer for spinning process enhancement. The PP/PES blend fibers containing 8 wt % of polyester as dispersed phase were prepared in a two‐step procedure: preparation of FPA using laboratory twin‐screw extruder and spinning of the PP/PES blend fibers after blending PP and FPA, using a laboratory spinning equipment. DSC analysis was used for investigation of the phase structure of the PES components and selected blends. Finally, the mechanical properties of the blend fibers were analyzed. It has been found that viscosity of the PET/PBT blends is strongly influenced by the presence of the major component. In addition, the major component suppresses crystallinity of the minor component phase up to a concentration of 30 wt %. PBT as major component in dispersed PES phase increases viscosity of the PET/PBT blend melts and increases the tensile strength of the PP/PES blend fibers. The impact of the compatibilizer on the uniformity of phase dispersion of PP/PES blend fibers was demonstrated. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4222–4227, 2006 相似文献
110.