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41.
Assembly of the higher-order structure of mitotic chromosomes is a prerequisite for proper chromosome condensation, segregation and integrity. Understanding the details of this process has been limited because very few proteins involved in the assembly of chromosome structure have been discovered. Using a human autoimmune scleroderma serum that identifies a chromosomal protein in human cells and Drosophila embryos, we cloned the corresponding Drosophila gene that encodes the homologue of vertebrate titin based on protein size, sequence similarity, developmental expression and subcellular localization. Titin is a giant sarcomeric protein responsible for the elasticity of striated muscle that may also function as a molecular scaffold for myofibrillar assembly. Molecular analysis and immunostaining with antibodies to multiple titin epitopes indicates that the chromosomal and muscle forms of titin may vary in their NH2 termini. The identification of titin as a chromosomal component provides a molecular basis for chromosome structure and elasticity. 相似文献
42.
G. Rhodes, A. J. Parkin, and T. Tremewan (1993) have shown that semantic priming influences signal detection theory measures of sensitivity in visual word recognition. Following an argument presented by M. Farah (1989), they suggested that this is evidence that semantic information influences perceptual encoding, and that such an influence represents a violation of modularity. This article shows that, contrary to Farah's claim, measures of sensitivity cannot be assumed to reflect the operation of perceptual encoding. Simulations are presented to demonstrate that modular criterion-bias models of priming in which priming has no effect on perceptual encoding predict the same sensitivity effects that Rhodes et al take as evidence against modularity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
43.
J Norris L Harnack S Carmichael T Pouane P Wakimoto G Block 《Canadian Metallurgical Quarterly》1997,87(5):740-746
OBJECTIVES: This study examined US trends in nutrient intake, using almost identical methods and nutrient databases in two time periods. METHODS: An extensive dietary intake questionnaire was included in supplements to the 1987 and 1992 National Health Interview Surveys. Dietary data from approximately 11,000 persons in each of those years were analyzed. RESULTS: The total and saturated fat intake and the percentage of energy from fat declined among Whites and Hispanics, but only minimal changes were seen in Black Americans. The changes in fat intake were attributable principally to behavioral changes in frequency and type of fat-containing foods consumed rather than to the increased availability of leaner cuts of meat. Dietary cholesterol showed one of the largest declines of the nutrients examined. Less desirable changes were also seen. Cereal fortification played an important role in the observed changes in several micronutrients. CONCLUSIONS: Educational campaigns on dietary fat and cholesterol have been moderately effective, but not in all racial/ethnic groups. Future campaigns should emphasize maintaining or increasing micronutrient intake. 相似文献
44.
Tomarken Andrew J.; Davidson Richard J.; Wheeler Robert E.; Doss Robert C. 《Canadian Metallurgical Quarterly》1992,62(4):676
Assessed whether individual differences in anterior brain asymmetry are linked to differences in basic dimensions of emotion. In each of 2 experimental sessions, separated by 3 wks, resting EEG activity was recorded from female adults during 8 60-sec baselines. Mean alpha power asymmetry across both sessions was extracted in mid-frontal and anterior temporal sites. Across both regions, groups demonstrating stable and extreme relative left anterior activation reported increased generalized positive affect (PAF) and decreased generalized negative affect (NAF) compared with groups demonstrating stable and extreme relative right anterior activation. Additional correlational analyses revealed robust relations between anterior asymmetry and PAF and NAF, particularly among Ss who demonstrated stable patterns of EEG activation over time. Anterior asymmetry was unrelated to individual differences in generalized reactivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
45.
Domjan Michael; Mahometa Michael J.; Mills Andrew D. 《Canadian Metallurgical Quarterly》2003,117(4):391
Two contrasting investigative techniques provided evidence consistent with the interpretation that female quail (Coturnix japonica) regulate male copulatory behavior by the duration of their immobility and through this behavioral mechanism they also control the rate of fertilization of their eggs. In Experiment 1, copulation tests with males and females from different genetic lines showed that the type of female that participated in a copulatory test significantly influenced the latency of the male's grab, mount, and cloacal contact responses and also determined the efficiency of the male's copulatory behavior. These measures of male performance were correlated with female immobility in Experiment 2, which used a more homogeneous population of quail. Furthermore, 2 of these measures (copulatory efficiency and the latency to make cloacal contact) were correlated with fertilization rate. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
46.
Marcela Brugnach Andrew Tagg Florian Keil Wim J. de Lange 《Water Resources Management》2007,21(7):1075-1090
The use of computer models offers a general and flexible framework that can help to deal with some of the complexities and
difficulties associated with the development of water management plans as prescribed by the Water Framework Directive. However,
despite the advantages modelling presents, the integration of information derived from models into policy is far away from
being trivial or the norm. Part of the difficulties of this integration is rooted in the lack of confidence policy makers
have on the incorporation of modelling information into policy formulation. In this paper we examine the reasons for this
apparent lack of confidence and explore how some tools, presently in use, address this problem. We conclude that public confidence
in models is highly dependent on the way uncertainties are addressed and suggest possible directions of action to improve
the current situation. Four real case studies illustrate how computer models have been used in The Netherlands for carrying
out management plans at regional and national scale. We suggest that the solution to integrate modelling information into
policy formulation lies on both the modelling and the policy-making communities. 相似文献
47.
48.
49.
The group scanning model of feature integration theory suggests that Ss search visual displays serially by groups, but process items within each group in parallel. Group size is determined by the discriminability of the targets in the background of distractors. When the target is poorly discriminable, the size of the scanned group will be small, and search will be slow. The model predicts that group size will be smallest when targets of an intermediate value on a perceptual dimension are presented in a heterogeneous background of distractors that have higher and lower values on the same dimension. Experiment 1 (30 Ss) demonstrates this effect; Exp 2 (12 Ss) controls for a possible confound of decision complexity in Exp 1. For simple feature targets, the group scanning model provides a good account of the visual search process. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
50.
Assessed whether resting anterior asymmetry would discriminate individual differences in repressive-defensive coping styles. In 2 sessions, resting electroencephalogram was recorded from female adults during 8 60-sec baselines. Ss were classified as repressors or nonrepressors on the basis of scores on the Marlowe-Crowne Social Desirability Scale (MC), the State-Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). In midfrontal and lateral frontal sites, repressors demonstrated relative left hemisphere activation when compared with other groups. The MC, but not the STAI or the BDI, contributed unique variance to frontal asymmetry. Relative left frontal activation may be linked to a self-enhancing regulatory style that promotes lowered risk for psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献