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991.
Andrew Todd 《Architectural Design》2020,90(6):100-109
Neuroscience and phenomenology are valuable tools for architects who wish to increase our engagement with the world as a commonly lived nexus, rather than as a locus of showing-off and design-branding. Andrew Todd , architect, argues that our connection with the world can be extended by deeper consideration of plants and their role in architecture. 相似文献
992.
James K. Forder Andrew J. Ilott Erinc Sahin Christopher J. Roberts 《American Institute of Chemical Engineers》2023,69(4):e17965
Attractive self-interactions of therapeutic proteins are linked to problematic solution behaviors at high protein concentrations such as reversible or irreversible aggregation, high viscosity, opalescence, phase separation, and low solubility. Prediction of attractive self-interactions early in development can improve the processes of formulation development and candidate selection. To that end, a coarse-grained model with explicit representation of charged sites was used to accurately predict a broad range of protein self-interactions at high protein concentrations (up to 160 mg/ml) for multiple monoclonal antibodies and formulations, including strong electrostatic attractions, with static light scattering measurements at low protein concentrations as the only experimental input. In addition, Mayer-weighted electrostatic energies for charged residues from these simulations can contribute to understanding of electrostatic interactions and guide the development of protein variants. 相似文献
993.
Andrew J. Russell Maurizio Collu Alasdair S. McDonald Philipp R. Thies Aidan Keane Alexander R. Quayle 《风能》2024,27(4):341-362
Nacelle-mounted, forward-facing light detection and ranging (LIDAR) technology can deliver benefits to rotor speed regulation and loading reductions of floating offshore wind turbines (FOWTs) when assisting with blade pitch control in above-rated wind speed conditions. Large-scale wind turbines may be subject to significant variations in structural loads due to differences in the wind profile across the rotor-swept area. These loading fluctuations can be mitigated by individual pitch control (IPC). This paper presents a novel LIDAR-assisted feedforward IPC approach that uses each blade's rotor azimuth position to allocate an individual pitch command from a multi-beam LIDAR. In this study, the source code of OpenFAST wind turbine modelling software was modified to enable LIDAR simulation and LIDAR-assisted control. The LIDAR simulation modifications were accepted by the National Renewable Energy Laboratory (NREL) and are now present within OpenFAST releases from v3.5 onwards. Simulations of a 15 MW FOWT were performed across the above-rated wind spectrum. Under a turbulent wind field with an average wind speed of 17 ms−1, the LIDAR-assisted feedforward IPC delivered up to 54% reductions in the root mean squared errors and standard deviations of key FOWT parameters. Feedforward IPC delivered enhancements of up to 12% over feedforward collective pitch control, relative to the baseline feedback controller. The reductions to the standard deviation and range of the rotor speed may enable structural optimization of the tower, while the reductions in the variations of the loadings present an opportunity for reduced fatigue damage on turbine components and, consequently, a reduction in maintenance expenditure. 相似文献
994.
Debapriya P. Mohanty;James B. Mann;Vijayakumar Niranjan Payathuparambil;Sweta Baruah;Jessica K. Román-Kustas;Andrew B. Kustas;Tatsuya Sugihara;Kevin P. Trumble;Srinivasan Chandrasekar; 《Advanced Materials Technologies》2024,9(4):2301315
Next-generation, high-efficiency energy storage and conversion systems require development of lithium metal batteries. But the high cost of production and constraints on thickness of lithium (anode) foils continue to limit adoption for integration into battery cell architectures. Here, a novel lithium anode manufacturing solution is demonstrated – single-step production of ultrathin gauge foil formats directly from solid ingot. Hybrid cutting-based deformation processes, involving large plastic strains and strain rates, produce foil to sub-10 µm thickness, with surface quality even superior to present Li anode processing routes. Energy analysis shows the single-stage processing is ≈50% more efficient than conventional processing by extrusion-rolling. Through in situ force measurements and high-speed imaging of the cutting it also characterize – for the first time – the flow stress of Li to strain rates of 800 sec−1, revealing a power-law relationship. The results present a paradigm shift in manufacturing and integration of solid lithium anodes for energy applications. 相似文献
995.
Syed Ibrahim Gnani Peer Mohamed;Shahriar Namvar;Tan Zhang;Hessam Shahbazi;Zhen Jiang;Andrew M. Rappe;Amin Salehi-Khojin;Siamak Nejati; 《Advanced materials (Deerfield Beach, Fla.)》2024,36(14):2309302
The inability to process many covalent organic frameworks (COFs) as thin films plagues their widespread utilization. Herein, a vapor-phase pathway for the bottom-up synthesis of a class of porphyrin-based COFs is presented. This approach allows integrating electrocatalysts made of metal-ion-containing COFs into the electrodes’ architectures in a single-step synthesis and deposition. By precisely controlling the metal sites at the atomic level, remarkable electrocatalytic performance is achieved, resulting in unprecedentedly high mass activity values. How the choice of metal atoms, i.e., cobalt and copper, can determine the catalytic activities of POR-COFs is demonstrated. The theoretical data proves that the Cu site is highly active for nitrate conversion to ammonia on the synthesized COFs. 相似文献
996.
Audrey Olivier Sevin Mohammadi Andrew W. Smyth Matt Adams 《Computer-Aided Civil and Infrastructure Engineering》2023,38(18):2614-2631
The integration of data-driven models such as neural networks for high-consequence decision making has been largely hindered by their lack of predictive power away from training data and their inability to quantify uncertainties often prevalent in engineering applications. This article presents an ensembling method with function-space regularization, which allows to integrate prior information about the function of interest, thus improving generalization performance, while enabling quantification of aleatory and epistemic uncertainties. This framework is applied to build a probabilistic ambulance travel time predictor, leveraging historical ambulance data provided by the Fire Department of New York City. Results show that the integration of a non-Gaussian likelihood and prior information from a road network analysis yields appropriate probabilistic predictions of travel times, which could be further leveraged for emergency medical service (EMS) decision making. 相似文献
997.
998.
Hareesh Iyer Paul Grandgeorge Andrew M. Jimenez Ian R. Campbell Mallory Parker Michael Holden Mathangi Venkatesh Marissa Nelsen Bichlien Nguyen Eleftheria Roumeli 《Advanced functional materials》2023,33(40):2302067
Since the 1950s, 8.3 billion tonnes (Bt) of virgin plastics have been produced, of which around 5 Bt have accumulated as waste in oceans and other natural environments, posing severe threats to entire ecosystems. The need for sustainable bio-based alternatives to traditional petroleum-derived plastics is evident. Bioplastics produced from unprocessed biological materials have thus far suffered from heterogeneous and non-cohesive morphologies, which lead to weak mechanical properties and lack of processability, hindering their industrial integration. Here, a fast, simple, and scalable process is presented to transform raw microalgae into a self-bonded, recyclable, and backyard-compostable bioplastic with attractive mechanical properties surpassing those of other biobased plastics such as thermoplastic starch. Upon hot-pressing, the abundant and photosynthetic algae spirulina forms cohesive bioplastics with flexural modulus and strength in the range 3–5 GPa and 25.5–57 MPa, respectively, depending on pre-processing conditions and the addition of nanofillers. The machinability of these bioplastics, along with self-extinguishing properties, make them promising candidates for consumer plastics. Mechanical recycling and fast biodegradation in soil are demonstrated as end-of-life options. Finally, the environmental impacts are discussed in terms of global warming potential, highlighting the benefits of using a carbon-negative feedstock such as spirulina to fabricate plastics. 相似文献
999.
Richard Gordon Sharpe Andrew Brooks Jon Olley Justine Kemp 《Journal of Flood Risk Management》2023,16(2):e12892
Flow resistance through riparian forests due to drag on trees is often expressed in hydraulic models with an increase in a boundary resistance factor such as Manning's n. However, when Manning's n is used as a proxy for vegetation drag, this parameter is dependent on flow conditions and a single, uniform value may be inadequate for simulating a broad range of flood magnitudes. To investigate this issue, flow resistance, and the commensurate Manning's n values through a riparian forest were computed using measured drag forces and estimates of the forest structure and tree morphology. The computed Manning's n values were applied to a 2D hydraulic model (TUFLOW) to simulate an observed flood and a range of design floods. Modelled peak flood levels for the observed flood were 0.16 m lower on average than that recorded at debris marks. There was little difference in modelled flood levels when using the computed Manning's n compared to a traditional, uniform Manning's n. Reassuringly, the traditional method appears adequate when reliable calibration data is available. Otherwise, the method developed here provides a useful alternative in cases where calibration data is limited or for testing reforestation as a nature-based solution in river or flood management. 相似文献
1000.
Naila Naz Syeda F. Naqvi Nadine Hohn Kiara Whelan Phoebe Littler Federico Roncaroli Andrew C. Robinson Jaleel A. Miyan 《International journal of molecular sciences》2023,24(1)
We investigated the cerebral folate system in post-mortem brains and matched cerebrospinal fluid (CSF) samples from subjects with definite Alzheimer’s disease (AD) (n = 21) and neuropathologically normal brains (n = 21) using immunohistochemistry, Western blot and dot blot. In AD the CSF showed a significant decrease in 10-formyl tetrahydrofolate dehydrogenase (FDH), a critical folate binding protein and enzyme in the CSF, as well as in the main folate transporter, folate receptor alpha (FRα) and folate. In tissue, we found a switch in the pathway of folate supply to the cerebral cortex in AD compared to neurologically normal brains. FRα switched from entry through FDH-positive astrocytes in normal, to entry through glial fibrillary acidic protein (GFAP)-positive astrocytes in the AD cortex. Moreover, this switch correlated with an apparent change in metabolic direction to hypermethylation of neurons in AD. Our data suggest that the reduction in FDH in CSF prohibits FRα-folate entry via FDH-positive astrocytes and promotes entry through the GFAP pathway directly to neurons for hypermethylation. This data may explain some of the cognitive decline not attributable to the loss of neurons alone and presents a target for potential treatment. 相似文献