M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors

Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.     

Graphene sheets stabilized on genetically engineered M13 viral templates as conducting frameworks for hybrid energy-storage materials

Utilization of the material-specific peptide-substrate interactions of M13 virus broadens colloidal stability window of graphene. The homogeneous distribution of graphene is maintained in weak acids and increased ionic strengths by complexing with virus. This graphene/virus conducting template is utilized in the synthesis of energy-storage materials to increase the conductivity of the composite electrode. Successful formation of the hybrid biological template is demonstrated by the mineralization of bismuth oxyfluoride as a cathode material for lithium-ion batteries, with increased loading and improved electronic conductivity.     

Measuring harmonic distortion in electrical power networks – New approach

Standard specification for power network quality diagnostic systems requires synchronization of sampling rate to the network frequency in every 10 s in order to ensure high accuracy of harmonic analysis. The total harmonic distortion (THD) cumulates measurement errors, therefore it is the most sensitive parameter to the frequency synchronization. This paper investigates two main effects putting impact on the THD computation accuracy. The first is the effect of the base clock rate of sampling hardware and the second is the practical deviation of network frequency during the 10 s synchronization period. The relative accuracy of THD calculation is examined in different real practical solutions and different synchronization methods are discussed and assessed. Theoretical proof and practical demonstration are given to show the needs of special synchronization methods in certain measuring circumstances.     

Poverty, loss, and resilience: The story of Chinese immigrant youth.

A total of 10 focus groups were conducted with students, parents, teachers, and school counseling and support personnel to investigate the cultural adjustment process of Chinese immigrant youth using an ecological framework. Multi-informant data were analyzed using the grounded theory (A. Strauss & J. M. Corbin, 1998) method. Findings reveal 6 main themes: socioeconomic changes due to immigrant status; English proficiency as a barrier to adjustment; changes in family structure and dynamics, racism, and invisibility; challenges to social support systems; and interdependent strategies for navigating in the United States. Results highlight the dynamic interaction and tensions created across themes and ecological contexts. The need for school- and community-based counseling interventions that address Chinese immigrant youths' losses and foster their resiliency and supportive networks are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Supercritical fluid extraction of bioactive lipids from the microalga Nannochloropsis sp.

Marine microalgae are recognised as an important renewable source of bioactive lipids with a high proportion of polyunsaturated fatty acids (PUFA), which have been shown to be effective in preventing or treating several diseases. For the extraction of oil from microalgae, supercritical CO₂ (ScCO₂) is regarded with interest, being safer than hexane and offering a negligible environmental impact, a short extraction time and a high‐quality final product. Whilst some experimental papers are available on the supercritical fluid extraction (SFE) of oil from microalgae, only limited information exists on the kinetics of the process. In such a contest, a mathematical model able to describe the kinetics of the SFE was applied to the recovery with ScCO₂ of lipids from Nannochloropsis sp., a marine microalga commonly used in aquaculture and characterised by a lipid fraction with a high PUFA content. The aim of this paper was to examine the effect of operating conditions on the kinetics of the SFE, on process yields and on the fatty acid composition of lipid extracts.     

Tight bounds for three-dimensional nonlinear incompressible elastic composites

Tighter variational bounds, in the whole range of inclusion volume fraction, that is to say, even near percolation, for the effective energy of nonlinear composites, in the special case of 3D two-phase incompressible elastic composites with isotropic constituents are presented. Following the methodology of Talbot, Willis and Ponte Castañeda, a linear comparison material with the same microgeometry as the nonlinear composite is employed. The asymptotic homogenization method (AHM) combined with a finite element analysis (FEM), is used to find the displacement field as well as the effective properties for the comparison material. An elastic composite with periodically distributed spherical inclusions in a cubic array is considered as an example. Various numerical examples are performed. Comparisons with others theories (i.e. variational bounds, self-consistent estimates, etc.) are shown. Coincidence of the AHM-FEM results with the universal bounds of Nemat-Nasser, Yu and Hori serves as a useful check to the numerical calculation.     

Activation of self-observation: A core process among the psychotherapies.

Activation of self-observation is proposed as a core psychotherapy process. Self-observation entails an active scan of one's inner landscape (intentions, expectations, feelings, cognitions, and behaviors), the ability to introspect on one's own thoughts, and the realization of the relation of self to one's social and cultural environment. This process is collaboratively employed by psychotherapist and client within all psychotherapy orientations to help clients learn about their own functioning, change maladaptive responses, and generate new responses for the future. This article addresses (a) defining and distinguishing features of self-observation, (b) self-observation within the psychotherapeutic encounter, (c) ways in which psychotherapists accelerate this process, and (d) the implications of self-observation as a core psychotherapeutic process. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Randomized trial of group interventions to reduce HIV/STD risk and change theoretical mediators among detained adolescents.

Criminally involved adolescents engage in high levels of risky sexual behavior and alcohol use, and alcohol use may contribute to lack of condom use. Detained adolescents (n = 484) were randomized to (1) a theory-based sexual risk reduction intervention (GPI), (2) the GPI condition with a group-based alcohol risk reduction motivational enhancement therapy component (GPI + GMET), or (3) an information-only control (INFO). All interventions were presented in same-sex groups in single sessions lasting from 2 to 4 hr. Changes to putative theoretical mediators (attitudes, perceived norms, self-efficacy, and intentions) were measured immediately following intervention administration. The primary outcomes were risky sexual behavior and sexual behavior while drinking measured 3 months later (65.1% retention). The GPI + GMET intervention demonstrated superiority over both other conditions in influencing theoretical mediators and over the INFO control in reducing risky sexual behavior. Self-efficacy and intentions were significant mediators between condition and later risky sexual behavior. This study contributes to an understanding of harm reduction among high-risk adolescents and has implications for understanding circumstances in which the inclusion of GMET components may be effective. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A study of colour emotion and colour preference. Part III: Colour preference modeling

In this study three colour preference models for single colours were developed. The first model was developed on the basis of the colour emotions, clean–dirty, tense–relaxed, and heavy–light. In this model colour preference was found affected most by the emotional feeling “clean.” The second model was developed on the basis of the three colour‐emotion factors identified in Part I, colour activity, colour weight, and colour heat. By combining this model with the colour‐science‐based formulae of these three factors, which have been developed in Part I, one can predict colour preference of a test colour from its colour‐appearance attributes. The third colour preference model was directly developed from colour‐appearance attributes. In this model colour preference is determined by the colour difference between a test colour and the reference colour (L*, a*, b*) = (50, ?8, 30). The above approaches to modeling single‐colour preference were also adopted in modeling colour preference for colour combinations. The results show that it was difficult to predict colour‐combination preference by colour emotions only. This study also clarifies the relationship between colour preference and colour harmony. The results show that although colour preference is strongly correlated with colour harmony, there are still colours of which the two scales disagree with each other. © 2004 Wiley Periodicals, Inc. Col Res Appl, 29, 381–389, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20047