HDJ003平面关节型装配机器人微机实时控制系统

介绍ＨＤＪ００３型平面关节型装配机器人微机实时控制系统的基本构成，包括控制系统的硬件组成，软件结构，控制系统分析与设计。最后给出机器人装配试验结果。     

Preparation of Zinc Titanate Thin Films by Low-Pressure Metalorganic Chemical Vapor Deposition

Homogeneous thin films of zinc titanate have been successfully prepared on Si(100) wafers by depositing a film of zinc and titanium oxides (ZnO-TiO₂) by low-pressure metalorganic chemical vapor deposition (MOCVD), followed by an annealing treatment. The precursors used for the deposition were diethylzinc (DEZ), tetraisopropoxide titanium (TPT), and water. By performing the deposition at temperatures between 140 and 350C, the stoichiometry of the as-deposited films could be effectively controlled over Zn/Ti ratios between 0.5 and 2.5, which cover the composition of various zinc titanate phases identified in the literature. The as-deposited ZnO-TiO₂ films are amorphous, and possess a fairly smooth surface. XPS and SIMS analysis showed that the composition of these films is uniform over the wafer as well as through the films bulk. An annealing treatment of the as-deposited films at high temperature     

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the progress in endoglin-based imaging of cancer, atherosclerosis, myocardial infarction, and aortic aneurysm, focusing on positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), near-infrared fluorescence (NIRF) imaging, and ultrasound imaging. PubMed was searched combining the following subjects and their respective synonyms or relevant subterms: “Endoglin”, “Imaging/Image-guided surgery”. In total, 59 papers were found eligible to be included: 58 reporting about preclinical animal or in vitro models and one ex vivo study in human organs. In addition to exact data extraction of imaging modality type, tumor or cardiovascular disease model, and tracer (class), outcomes were described via a narrative synthesis. Collectively, the data identify endoglin as a suitable target for intraoperative and diagnostic imaging of the neovasculature in tumors, whereas for cardiovascular diseases, the evidence remains scarce but promising.     

Platinum Cyclooctadiene Complexes with Activity against Gram-positive Bacteria

Antimicrobial resistance is a looming health crisis, and it is becoming increasingly clear that organic chemistry alone is not sufficient to continue to provide the world with novel and effective antibiotics. Recently there has been an increased number of reports describing promising antimicrobial properties of metal-containing compounds. Platinum complexes are well known in the field of inorganic medicinal chemistry for their tremendous success as anticancer agents. Here we report on the promising antibacterial properties of platinum cyclooctadiene (COD) complexes. Amongst the 15 compounds studied, the simplest compounds Pt(COD)X₂ (X=Cl, I, Pt1 and Pt2 ) showed excellent activity against a panel of Gram-positive bacteria including vancomycin and methicillin resistant Staphylococcus aureus. Additionally, the lead compounds show no toxicity against mammalian cells or haemolytic properties at the highest tested concentrations, indicating that the observed activity is specific against bacteria. Finally, these compounds showed no toxicity against Galleria mellonella at the highest measured concentrations. However, preliminary efficacy studies in the same animal model found no decrease in bacterial load upon treatment with Pt1 and Pt2 . Serum exchange studies suggest that these compounds exhibit high serum binding which reduces their bioavailability in vivo, mandating alternative administration routes such as e. g. topical application.     

The Influence of the Removal of Specific NOM Compounds by Anion Exchange on Ozone Demand,Disinfection Capacity,and Bromate Formation

This research on a pilot scale focuses on the reaction of ozone with natural organic matter (NOM) for three water qualities with different dissolved organic carbon (DOC) concentrations and NOM compositions, obtained after several stages of an anion exchange process. It was shown that for the same ozone dosage per DOC, the ozone demand was higher, less bromate was formed and a lower disinfection capacity was reached for water containing mainly humic substances, than for water where the humic substances were partly removed. It can be concluded that NOM composition, specifically the humic substances, influences the ozone demand, disinfection capacity and bromate formation.     

Hydrogel composites with temperature induced phase transition for biocatalysis

BACKGROUND: This paper focuses on the development of temperature induced phase transition hydrogels based on poly(N‐isopropylocrylamide (PNIPA) copolymers and their application as an immobilization matrix for biocatalysts. RESULTS: PNIPA‐co‐AAc and PNIPA‐co‐MAAc hydrogels were synthesized with different comonomer concentrations and analysed. In order to evaluate the capacity of hydrogels to take up or to release liquids the mass exchange capacity is introduced. In the presented work mass exchange capacities up to 22.4 were realized. To enhance the mechanical stability, composites of hydrogels and cellulosic fleeces were prepared. The enzyme Lipozyme ^® TL 100 L (Thermomyces languniosa Lipase) was successfully inserted into the hydrogels and into the hydrogel composites. Lipase‐catalysed transesterification of rapeseed oil with ethanol to the corresponding ethyl ester was investigated to prove the activity of immobilized enzyme and thus, the concept. The activity was found to be similar to that of free enzyme. CONCLUSION: Smart hydrogel composites were used for the transesterification of oil. Based on the results obtained, reversible loadable and mechanical stable hydrogel composites could be developed for continuous working reactor concepts. Copyright © 2010 Society of Chemical Industry     

薄壁壳体件的快速成型技术开发研究

快速成型技术是集计算机辅助设计、数控技术、精密机械、电子技术、激光技术,以及材料科学于一体的跨多学科领域的新型制造技术。在农机零部件的开发制造过程中,快速成型技术能够结合农机零部件铸型尺寸大、结构复杂的特点,通过铸件三维模型剖分、分块加工、坎合组装浇注等工艺技术,快速完成单件、小批量新产品的试制。在制造过程中,利用无模数字化快速成型机及激光烧结机,可加工出任意复杂形状的铸型,大幅缩短复杂铸件的开发周期,对促进企业产品创新、降低新产品研发成本、提高产品竞争力具有重大意义。     

Production of antibiotics by Collybia nivalis, Omphalotus olearis, a Favolaschia and a Pterula species on natural substrates

Collybia nivalis, Favolaschia sp. 87129, Pterula sp. 82168 and Omphalotus olearius were cultivated on natural substrates. The antibiotic metabolites oudemansin A. strobilurins A, D, illudin S and pterulone were isolated and identified. A new antifungal metabolite, pterulone B, was described from cultures of Pterula sp. 82168 on wood. Collybia nivalis was found to be the first species of this genus to produce strobilurins and oudemansin A. As compared to rich media the cultivation on natural substrates resulted in the production of fewer metabolites. The concentrations of the antibiotics, however, were sufficient to inhibit other saprophytic fungi.     

Characterization of laccases and peroxidases from wood-rotting fungi (family Coprinaceae)

Panaeolus sphinctrinus, Panaeolus papilionaceus, and Coprinus friesii are described as producers of ligninolytic enzymes. P. papilionaceus and P. sphinctrinus both produced a laccase. In addition, P. sphinctrinus produced a manganese peroxidase. C. friesii secreted a laccase and two peroxidases similar to the peroxidase of Coprinus cinereus. The purified laccases and peroxidases were characterized by broad substrate specificities, significant enzyme activities at alkaline pH values, and remarkably high pH optima. The two peroxidases of C. friesii remained active at pH 7.0 and 60 degrees C for up to 60 min of incubation. The peroxidases were inhibited by sodium azide and ethylene glycol-bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), whereas the laccases were inhibited by sodium azide and N,N-diethyldithiocarbamic acid. As determined by native polyacrylamide gel electrophoresis and isoelectric focusing, all three fungi produced laccase isoenzymes.