Numerical modeling of damage evolution of DP steels on the basis of X-ray tomography measurements

In order to couple the damage evolution and the stress state of DP steel grades, a new advanced GTN (Gurson-Tvergaard-Needleman) model was developed and implemented into a finite element code. This model is an extension of the original one. It takes into account the plastic anisotropy and the mixed (isotropic + kinematic) hardening of the matrix. Two different methods to compute the void volume fraction were developed and used within the constitutive equations. The first method is new and allows the accurate modeling of the observations of damage initiation and growth in DP steels measured using high-resolution X-ray absorption tomography ( [Bouaziz et al., 2008] and [Maire et al., 2008]). The second method is classic and assumes the additive decomposition of the total void volume fraction into a nucleation and a growth part. A parametric study is carried out to assess the effect of the kinematic hardening on some mechanical parameters such as the equivalent plastic strain, the triaxiality and the porosity. The numerical predictions are favorably compared to the experimental results.     

Cell design in bacteria as a convex optimization problem

In this paper, we investigate the prediction of the cell composition of bacteria with respect to their medium. By modeling the bacterium as an interconnection of subsystems, the problem is written as a non-smooth convex optimization problem equivalent to a Linear Programming feasibility problem. We then obtain a new method, called Resource Balance Analysis (RBA), predicting the distribution of the available resources in the medium among the various cellular subsystems. Beyond its predictive capability, the proposed approach grasps some fundamental aspects of the bacterium physiology by including a refined model. This method reveals the existence of an intrinsic bottleneck in the system resource distribution of the bacterium, leading to the existence of a structural limitation of its growth rate which can be predicted. RBA is also able to predict the configuration of the metabolic network for a given medium at steady-state regimen which nicely fits the available experimental results for the gram-positive model bacterium Bacillus subtilis.     

A smoothed radial point interpolation method for application in porodynamics

A meshfree numerical method for the dynamic analysis of porous media is presented. The u,?p form of Biot’s theory is adopted to mathematically model the dynamic interaction of the solid and the fluid phase within the porous media. The obtained partial differential equations (PDEs) are discretized by the generalized smoothed Galerkin weak form, which is established based on smoothed strains and fluxes. Therefore, edge-based and cell-based smoothing domains are used and a T3-scheme is employed for the selection of support nodes. The shape functions are generated by the radial point interpolation method. The focus of this work lies on the spatial integration of the mass/compressibility and coupling terms of the discrete PDE system. A new algorithm is introduced, which reuses the shape function values that are needed for the construction of the stiffness/permeability matrix to keep the computational effort at a minimum. Numerical problems are analyzed in order to test the algorithm regarding accuracy and efficiency.     

The development of railway safety in Finland

This study reviews the development of railway safety in Finland from 1959 to 2008. The results show that the level of safety has greatly improved over the past five decades. The total number of railway fatalities did not show any obvious decreasing or increasing trend during the first decade, but since the early 1970s the annual number of fatalities has decreased from about 100 to 20. The estimated overall annual reduction per year from 1970 to 2008 was 5.4% (with a 95% confidence interval from −8.2% to −2.6%). The reduction in subcategories per million train-kilometres from 1959 to 2008 was 4.4% per year for passengers, 8.3% for employees, 5.0% for road users at level crossings and 3.6% for others (mainly trespassers). The safety improvement for passengers and staff was probably influenced by the introduction of central locking of doors in passenger cars and improved procedures to protect railway employees working on the tracks. The number of road users killed at level crossings has fallen due to the installation of barriers and the construction of overpasses and underpasses at crossings with dense traffic, removal of level crossings, and an improvement of conditions such as visibility at crossings. The number of trespasser fatalities has seen the least decline. Key plans for the future include further reduction of the number of level crossings on the state railway network from the current roughly 3500–2200 by 2025, and involving communities in safety work related to railway trespassers.     

Finite element model updating and structural damage identification using OMAX data

The main limitations in the finite element (FE) model updating technique lie in the ability of the FE model to represent the true behavior of the structure (modelling problem), and in the ability to identify enough modal parameters with sufficient accuracy, especially for large structures that are tested in operational conditions (identification problem). In this paper, the identification problem is solved with an OMAX approach, where an artificial force is used in operational conditions and a structural model is identified that takes both the forced and the ambient excitation into account. From an extensive case study on a real three-span bridge, it is observed that, while updating the FE model using the experimental output-only data yields a good fit, discrepancies show up when the more extensive set of OMAX data is used for validation, or even for updating. It can be concluded that an OMAX approach not only increases the well-posedness of the updating problem, it also allows to detect potential inaccuracies in the FE model.     

The effect of ozonization on furniture dust: Microbial content and immunotoxicity in vitro

Moisture and mold problems in buildings contaminate also the furniture and other movable property. If cleaning of the contaminated furniture is neglected, it may continue to cause problems to the occupants even after the moisture-damage repairs. The aim of this study was to determine the effectiveness of high-efficiency ozone treatment in cleaning of the furniture from moisture-damaged buildings. In addition, the effectiveness of two cleaning methods was compared. Samples were vacuumed from the padded areas before and after the treatment. The microbial flora and concentrations in the dust sample were determined by quantitative cultivation and QPCR-methods. The immunotoxic potential of the dust samples was analyzed by measuring effects on cell viability and production of inflammatory mediators in vitro. Concentrations of viable microbes decreased significantly in most of the samples after cleaning. Cleaning with combined steam wash and ozonisation was more effective method than ozonising alone, but the difference was not statistically significant. Detection of fungal species with PCR showed a slight but nonsignificant decrease in concentrations after the cleaning. The immunotoxic potential of the collected dust decreased significantly in most of the samples. However, in a small subgroup of samples, increased concentrations of microbes and immunotoxicological activity were detected. This study shows that a transportable cleaning unit with high-efficiency ozonising is in most cases effective in decreasing the concentrations of viable microbes and immunotoxicological activity of the furniture dust. However, the method does not destroy or remove all fungal material present in the dust, as detected with QPCR analysis, and in some cases the cleaning procedure may increase the microbial concentrations and immunotoxicity of the dust.     

The association of distress and sleeping problems with physicians’ intentions to change profession: The moderating effect of job control.

The present study examined whether job control moderated the association between stress indicators (distress and sleeping problems) and intentions to change profession among 2,650 Finnish physicians. Ordinal logistic regression analysis was applied. The authors found that high levels of distress and sleeping problems were associated with higher levels of intentions to change profession, whereas high job control was associated with lower levels of intentions to change profession even after adjusting for the effects of gender, age, and employment sector. In addition, high job control was able to mitigate the positive association that distress and sleeping problems had with intentions to change profession. Our findings highlight the importance of offering more job control to physicians to prevent unnecessary physician turnover. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD

Object  The aim of our study was to determine total cystic volume in a mouse model of PKD using MR imaging to monitor therapeutic effects in vivo. Materials and methods  We imaged eight female pcy-mice in two groups: four belonged to an untreated control group and four were treated with the anticystic agent rapamycin, which has proven to be effective in reducing cystogenesis in animal models. The mice were imaged using a 9.4 Tesla animal scanner. MRI measurements were taken at six time points during the therapy. Total renal volumes and total cyst volumes were calculated using a thresholding approach. Results  During the course of the treatment, the total cyst volume increased significantly faster than the total renal volume in the untreated group, indicating that growth of the total renal volume in the untreated group was primarily due to the growth of the cysts, rather than the parenchyma. The measured total renal volume in the control (placebo) group was significantly higher than the volume in the treated group. Conclusion  Using MRI, we were able to monitor the cystic volume in a mouse model of PKD to assess the therapeutic effect of anticystic treatment.     

A stress-coping profile of opioid dependent individuals entering naltrexone treatment: A comparison with healthy controls.

Background: Stress is known to increase addiction vulnerability and risk of relapse to substance use. Purpose & Method: We compared opioid dependent individuals entering naltrexone treatment (n = 57) with healthy controls (n = 75) on measures of stress, coping, and social support and examined the relative contribution of group membership, coping, and social support to stress within the sample. Analyses of variance (ANOVA) and covariance (ANCOVA), and stepwise multiple regression were conducted. Results: Compared with controls, opioid dependent subjects reported greater stress, less use of adaptive coping, but comparable use of maladaptive/avoidant coping. No group differences were found with respect to social support. Perceived stress was predicted by group membership, low social support, and greater use of maladaptive/avoidant coping, and the prediction by social support and maladaptive/avoidant coping did not differ by group. Conclusion: Opioid dependent individuals entering naltrexone treatment experience higher levels of stress and report less use of adaptive coping strategies when compared with controls. Group membership, maladaptive/avoidant coping, and social support independently contribute to perceived stress. Findings suggest that novel treatment approaches that decrease maladaptive/avoidant coping and improve social support are important aspects of decreasing stress during early recovery from opioid addiction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The culture gap and its needed closures

The development of an enormous culture gap, in which no individuals of advanced societies possess even a billionth of the non‐genetic information possessed by their entire society, has threatened a global collapse of civilisation. Critical parts of that gap must be rapidly bridged so that problems such as climate disruption, toxification of the Earth, loss of biodiversity and ecosystem services, and the decay of the epidemiological environment can be satisfactorily attacked. The essential need is to alter human behaviour to put society on a route to sustainability; one cheering development is a growing interest in the Millennium Assessment of Human Behaviour (MAHB), whose goal is to do just that.