A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study

Objective: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis, but there is limited information about the genetic contribution to atherosclerosis in this population. Therefore, we examined the association between selected genetic polymorphisms and coronary atherosclerosis in patients with RA. Methods: Genotypes for single-nucleotide polymorphisms (SNPs) in 152 candidate genes linked with autoimmune or cardiovascular risk were measured in 140 patients with RA. The association between the presence of coronary artery calcium (CAC) and SNP allele frequency was assessed by logistic regression with adjustment for age, sex, and race. To adjust for multiple comparisons, a false discovery rate (FDR) threshold was set at 20%. Results: Patients with RA were 54 ± 11 years old and predominantly Caucasian (89%) and female (69%). CAC was present in 70 patients (50%). A variant in rs2073618 that encodes an Asn3Lys missense substitution in the osteoprotegerin gene (OPG, TNFRSF11B) was significantly associated with the presence of CAC (OR = 4.09, p < 0.00026) and withstands FDR correction. Conclusion: Our results suggest that a polymorphism of the TNFRSF11B gene, which encodes osteoprotegerin, is associated with the presence of coronary atherosclerosis in patients with RA. Replication of this finding in independent validation cohorts will be of interest.     

Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis

Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. Although interferons are usually safe and well tolerated, they frequently cause dermatological side effects. Here, we present a multiple sclerosis (MS) patient treated with interferon-β who developed new-onset psoriasis. Both her MS as well as her psoriasis finally responded to treatment with fumarates. This case illustrates that interferons not only cause local but also systemic adverse events of the skin. These systemic side effects might indicate that the Th17/IL-17 axis plays a prominent role in the immunopathogenesis of this individual case and that the autoimmune process might be deteriorated by further administration of interferons. In conclusion, we think that neurologists should be aware of systemic cutaneous side effects and have a closer look on interferon-associated skin lesions. Detection of psoriasiform lesions might indicate that interferons are probably not beneficial in the individual situation. We suggest that skin lesions may serve as biomarkers to allocate MS patients to adequate disease-modifying drugs.     

Estimating the Vigdergauz constants for regular hexagonal honeycombs

In this paper we propose a new model for estimating the effective properties of regular hexagonal honeycombs. This model yields some new simple formulae which, in contrast to previous attempts, match the general invariant relations found by Vigdergauz in 1999. By comparing with numerical results, we also find some improved (but still simple) formulae which enable us to estimate the effective properties with an accuracy better than 1%, even for high density honeycombs.     

Marriage and the spiritual realm: The role of proximal and distal religious constructs in marital functioning.

Ninety-seven couples completed questionnaires about their involvement in joint religious activities and their perceptions regarding the sanctification of marriage, including perceived sacred qualities of marriage and beliefs about the manifestation of God in marriage. In contrast to individual religiousness and religious homogamy (distal religious constructs), these proximal religious variables directly reflect an integration of religion and marriage, and they were associated with greater global marital adjustment, more perceived benefits from marriage, less marital conflict, more verbal collaboration, and less use of verbal aggression and stalemate to discuss disagreements for both wives and husbands. The proximal measures also added substantial unique variance (adjusted R2 change ranged from .06 to .48) to specific aspects of marital functioning after controlling demographic factors and distal religious variables in hierarchical regression analyses. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Coping through emotional approach: Scale construction and validation.

Four studies demonstrate the psychometric adequacy and validity of scales designed to assess coping through emotional approach. In separate undergraduate samples, exploratory and confirmatory factor analyses of dispositional (Study 1) and situational (Study 3) coping item sets yielded 2 distinct emotional approach coping factors: emotional processing (i.e., active attempts to acknowledge and understand emotions) and emotional expression. The 2 scales yielded high internal consistency and test-retest reliability, as well as convergent and discriminant validity. A study (Study 2) of young adults and their parents established the scales' interjudge reliabilities. Longitudinal (Study 3) and experimental (Study 4) research supported the predictive validity of the emotional approach coping scales with regard to adjustment to stressful encounters. Findings highlight the utility of functionalist theories of emotion as applied to coping theory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial aspects of selected issues in women's reproductive health: Current status and future directions.

Emphasizing research published in the past decade, this article presents a summary and evaluation of psychosocial investigations of women's reproductive health, with a focus on selected aspects of menstruation, pregnancy and birth, infertility, and menopause. In some areas, studies have focused on negative physical and psychological concomitants of these health issues. However, research reveals substantial individual variability, with most women adapting well to reproductive health changes. Although methodological and conceptual shortcomings have limited firm conclusions, research has advanced our understanding of the multivariate biological, psychological, and social influences on women's reproductive health and associated outcomes. Understanding and promoting women's reproductive health across the lifespan requires biopsychosocial approaches to research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the Possibility of s+d Wave Superconductivity Within a Two-Band Scenario for High Tc Cuprates

A variety of different experimental results show substantial evidence that the order parameter in high-temperature superconducting copper oxides is not of pure d-wave symmetry, but that an s-wave component exists, which especially shows up in experiments that test the c-axis properties. These findings are modeled theoretically within a two-band model with interband interactions, where the superconducting order parameters in the two bands are allowed to differ in symmetry. It is found that the coupling of order parameters with different symmetries (s+d) leads to substantial enhancements of the superconducting transition temperature T _c as compared to order parameters with only s-wave symmetry. An additional enhancement factor of T _c is obtained from the coupling of the bands to the lattice where moderate couplings favor superconductivity while too strong couplings lead to electron (hole) localization and consequently suppress superconductivity.     

Context and the interpretation of likelihood information: The role of intergroup comparisons on perceived vulnerability.

Four experiments investigated how people's perceptions about a group's (e.g., women's) vulnerability to a disease are influenced by information about the prevalence of the disease in a comparable group (e.g., men). Participants read symptom and prevalence information about fictitious diseases before answering questions regarding target group vulnerability. Participants used the prevalence rate for a nontarget group as an immediate comparison standard for intuitively interpreting the degree of vulnerability of a target group, resulting in robust contrast effects. Experiments 3 and 4 illustrated that these contrast effects can cause a person's intuitive perceptions about a group's vulnerability to selected diseases to conflict with his or her knowledge of the prevalence rates for the diseases. The results support a distinction between 2 components of psychological uncertainty--beliefs in objective probability and more intuitive perceptions of certainty. (PsycINFO Database Record (c) 2010 APA, all rights reserved)